A5002382709- Frailty in Older Adults
- Diabetes Management and Research
- Chronic Disease Management Strategies
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Protease and Inhibitor Mechanisms
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Lipoproteins and Cardiovascular Health
- Extracellular vesicles in disease
- Sepsis Diagnosis and Treatment
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Mitochondrial Function and Pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Telomeres, Telomerase, and Senescence
- melanin and skin pigmentation
- COVID-19 and healthcare impacts
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- COVID-19 diagnosis using AI
Istituto Nazionale di Riposo e Cura per Anziani
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
University of L'Aquila
1985-2017
Institute on Aging
2010-2016
Università di Camerino
1991-2015
Marche Polytechnic University
2009
I.R.C.C.S. Oasi Maria SS
1996-2009
Ospedali Riuniti di Ancona
2001
University of Rome Tor Vergata
1987
The role of epigenetics in endothelial cell senescence is a cutting-edge topic ageing research. However, little known the relative contribution to pro-senescence signal propagation provided by microRNAs shuttled extracellular vesicles (EVs) released from senescent cells. Analysis microRNA and DNA methylation profiles non-senescent (control) (SEN) human umbilical vein cells (HUVECs), profiling their cognate small EVs (sEVs) large demonstrated that SEN significantly greater sEV number than...
Currently there is debate on whether hypoglycemia an independent risk factor for atherosclerosis, but little attention has been paid to the effects of recovery from hypoglycemia. In normal control individuals and in people with type 1 diabetes, a 2-h induced was obtained by reaching normoglycemia or hyperglycemia another 2 h then maintaining glycemia following 6 h. Hyperglycemia after also repeated concomitant infusion vitamin C. Recovery accompanied significant improvement endothelial...
Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion. However, GLP-1 also improves endothelial function in diabetes.Sixteen type 2 diabetic patients and 12 control subjects received a meal, an oral glucose tolerance test (OGTT), two hyperglycemic clamps, with or without GLP-1. The clamps were repeated after months of strict glycemic control.During the glycemia, nitrotyrosine, plasma 8-iso prostaglandin F2α (8-iso-PGF2a) remained unchanged subjects, whereas they increased patients....
// Fabiola Olivieri 1,2 , Liana Spazzafumo 3 Massimiliano Bonafè 4 Rina Recchioni 2 Francesco Prattichizzo 1 Fiorella Marcheselli Luigina Micolucci Emanuela Mensà Angelica Giuliani Gabriele Santini Mirko Gobbi Raffaella Lazzarini Massimo Boemi 5 Roberto Testa 6 Antonicelli 7 Antonio Domenico Procopio and Anna Rita Bonfigli 8 Department of Clinical Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy Center Pathology Innovative Therapy,...
Aging | doi:10.18632/aging.100693. Fabiola Olivieri, Massimiliano Bonafè, Liana Spazzafumo, Mirko Gobbi, Francesco Prattichizzo, Rina Recchioni, Fiorella Marcheselli, Lucia La Sala, Roberta Galeazzi, Maria Rita Rippo, Gianluca Fulgenzi, Sabrina Angelini, Raffaella Lazzarini, Anna Bonfigli, Francesca Brugè, Luca Tiano, Stefano Genovese, Antonio Ceriello, Massimo Boemi, Claudio Franceschi, Domenico Procopio, Roberto Testa
The development of type-2 diabetes mellitus (T2DM) and its complications is largely due to the complex interaction between genetic factors environmental influences, mainly dietary habits lifestyle, which can either accelerate or slow down disease progression. Recent findings suggest potential involvement epigenetic mechanisms as a crucial interface effects predisposition factors. common denominator promoting T2DM progression that they trigger an inflammatory response, inflammation-mediated...
Background Glycosylation, i.e the enzymatic addition of oligosaccharides (or glycans) to proteins and lipids, known as glycosylation, is one most common co-/posttranslational modifications proteins. Many important biological roles glycoproteins are modulated by N-linked oligosaccharides. As glucose levels can affect pathways leading glycosylation proteins, we investigated whether metabolic syndrome (MS) type 2 diabetes mellitus (T2DM), pathological conditions characterized altered levels,...
Advanced glycation end-products (AGEs) and their interaction with the receptor for advanced (RAGE) play a pivotal role in development progression of type 2 diabetes. In this retrospective cohort study, we explored association circulating levels soluble RAGE (sRAGE) isoforms, i.e., endogenous secretory esRAGE cleaved cRAGE, AGEs respective ratios 15-year all-cause mortality diabetes.Baseline sRAGE isoforms concentration were measured by ELISA 362 patients diabetes 125 age- gender-matched...
Diabet. Med. 28, 1388–1394 (2011) Abstract Objective The key goal of diabetes management is to prevent complications. While the patho‐physiological mechanisms responsible for complications have been extensively studied, at present it impossible predict which patient with could develop In recent years, role leukocyte telomere length in pathogenesis cardiovascular disease and Type 2 has investigated. However, studies aiming investigate telomeres development progression diabetes, as well...
Intracellular antioxidant response to high glucose is mediated by Cu/Mn-superoxide dismutases (SOD-1/SOD-2), catalase (CAT) and glutathione peroxidases (GPx), particularly peroxidase-1 (GPx-1). Although oscillating can induce a more deleterious effect than on endothelial cells, the mechanism which exerts its dangerous effects incompletely understood; however, involvement of oxidative damage has been generally accepted. In this study we sought determine whether differentially modulates...
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia associated with alterations in carbohydrate, lipid, and protein metabolism. The prognosis of T2DM patients highly dependent on the development complications, therefore identification biomarkers progression, minimally invasive techniques, huge need. In present study, we applied 1H-Nuclear Magnetic Resonance (1H-NMR)-based metabolomic approach coupled multivariate data analysis to identify serum...
Innovative biomarkers are needed to improve the management of patients with type 2 diabetes mellitus (T2DM). Blood circulating miRNAs have been proposed as a potential tool detect T2DM complications, but lack tissue specificity, among other reasons, has hampered their translation clinical settings. Extracellular vesicle (EV)-shuttled an alternative approach. Here, we adapted immunomagnetic bead-based method isolate plasma CD31+ EVs harvest vesicles deriving from tissues relevant for...
Abstract Fibroblast Growth Factor 21 (FGF21), Differentiation 15 (GDF15), and Humanin (HN) are mitochondrial stress-related mitokines, whose role in health disease is still debated. In this study, we confirmed that their plasma levels positively correlated with age healthy subjects. However, when looking at patients type 2 diabetes (T2D) or Alzheimer’s (AD), two age-related diseases sharing a impairment, found GDF15 elevated T2D but not AD represents risk factor for complications, while...
A significant number of people, following acute SARS-CoV-2 infection, report persistent symptoms or new that are sustained over time, often affecting different body systems. This condition, commonly referred to as Long-COVID, requires a complex clinical management. In Italy health facilities specifically dedicated the diagnosis and care Long-COVID were implemented. However, activity these centers is highly heterogeneous, with wide variation in type services provided, specialistic expertise...
Metabolic syndrome is associated to chronic low grade inflammation, characterized by increased levels of inflammatory cytokines, such as Tumor Necrosis Factor-α (TNF-α) and Interleukin-6 (IL-6). In particular, TNF-α causes a decrease in the insulin-stimulated kinases related early phases insulin cascade, thereby leading resistance. Etanercept human fusion protein used treatment psoriasis arthritis. It blocks response interfering binding its receptors. The aim this case report study verify...
Mitochondrial dysfunction has been implicated in rare and common forms of type 2 diabetes (T2DM). Additionally, mitochondrial DNA (mtDNA) mutations have shown to be causal for T2DM pathogenesis. So far, many studies investigated the possibility that mtDNA variation might affect risk T2DM, however, when found, haplogroup association rarely replicated, even related populations, possibly due an inadequate level resolution. Effects on complications also proposed. However, additional evaluating...
Genetic association studies of age-related, chronic human diseases often suffer from a lack power to detect modest effects. Here we propose an alternative approach including healthy centenarians as more homogeneous and extreme control group. As proof principle focused on type 2 diabetes (T2D) assessed /genotypic associations 31 SNPs associated with T2D, complications metabolic genes relevant for telomere stability age-related diseases. We hypothesized that the frequencies risk variants are...
Abstract Background Adipocytokines are bioactive molecules that deeply involved in the occurrence of atherosclerosis, obesity, and autoimmune inflammatory diseases. Objectives This study was conducted to evaluate effects tumor necrosis factor‐ α ( TNF ‐ ) inhibitors on serum levels adipocytokines patients with chronic plaque psoriasis. Methods Serum adiponectin, resistin, visfatin, leptin, , interleukin‐6 IL ‐6) were evaluated sera obtained from 47 psoriasis, both at baseline after they had...