A5086749586- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Protease and Inhibitor Mechanisms
- Estrogen and related hormone effects
- Sepsis Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Immune Cell Function and Interaction
- Glycosylation and Glycoproteins Research
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- interferon and immune responses
- Hormonal Regulation and Hypertension
- Liver Disease Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- RNA Interference and Gene Delivery
- Mycobacterium research and diagnosis
- Peptidase Inhibition and Analysis
- T-cell and B-cell Immunology
- Peroxisome Proliferator-Activated Receptors
- HIV Research and Treatment
- Psoriasis: Treatment and Pathogenesis
- RNA and protein synthesis mechanisms
- Hepatitis B Virus Studies
- Adipose Tissue and Metabolism
- Gut microbiota and health
Vlaams Instituut voor Biotechnologie
2013-2025
Ghent University
2016-2025
VIB-UGent Center for Inflammation Research
2015-2024
University College London
2017-2019
Ghent University Hospital
1997-2018
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
2018
University of Alabama at Birmingham
2018
University of Bologna
2017
Public Health Service of Amsterdam
2017
Wellcome Centre for Human Neuroimaging
2017
Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 cell death and inflammation. We studied three Nec-1 analogs: Nec-1, active inhibitor RIPK1, inactive (Nec-1i), its variant, stable (Nec-1s), more variant. report that identical methyl-thiohydantoin-tryptophan, an potent immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO). Both Nec-1i inhibited human IDO, but Nec-1s did not, as predicted by molecular...
Research Article5 September 2016Open Access Transparent process Identification of a novel mechanism blood–brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles Sriram Balusu Inflammation Center, VIB, Ghent, Belgium Department Biomedical Molecular Biology, Ghent University, Medical Protein Research, Biochemistry, Search for more papers by this author Elien Van Wonterghem Riet De Rycke Koen Raemdonck Laboratory General Biochemistry and Physical...
Abstract In this paper, we hypothesize that X chromosome‐associated mechanisms, which affect X‐linked genes and are behind the immunological advantage of females, may also microRNAs. The human chromosome contains 10% all microRNAs detected so far in genome. Although role most them has not yet been described, several chromosome‐located have important functions immunity cancer. We therefore provide a detailed map described located on mouse chromosomes, highlight ones involved immune...
ABSTRACT Preclinical animal studies precede the majority of clinical trials. While definitions sepsis and recommended treatments are regularly updated, a systematic review preclinical models has not been done clear modeling guidelines lacking. To address this deficit, Wiggers-Bernard Conference on was held in Vienna May, 2017. The goal conference to identify limitations propose set guidelines, defined as “ Minimum Quality Threshold Sepsis Studies ” (MQTiPSS), enhance translational value...
<h3>Objective:</h3> To establish whether HIV disease is associated with abnormal levels of age-related brain atrophy, by estimating apparent age using neuroimaging and exploring these estimates related to status, age, cognitive performance, HIV-related clinical parameters. <h3>Methods:</h3> A large sample virologically suppressed HIV-positive adults (n = 162, 45–82 years) highly comparable HIV-negative controls 105) were recruited as part the Comorbidity in Relation AIDS (COBRA)...
Microglia, the mononuclear phagocytes of central nervous system (CNS), are important for maintenance CNS homeostasis, but also critically contribute to pathology. Here we demonstrate that nuclear factor kappa B (NF-κB) regulatory protein A20 is crucial in regulating microglia activation during homeostasis and In mice, deletion increases microglial cell number affects regulation neuronal synaptic function. Administration a sublethal dose lipopolysaccharide induces massive activation,...
We generated mice carrying a STAT3 allele amenable to Cre-mediated deletion and intercrossed them with Mx-Cre transgenic mice, in which the expression of Cre recombinase can be induced by type I interferon. Interferon-induced occurred very efficiently (more than 90%) liver slightly less (about 70%) bone marrow. Analysis induction acute-phase genes response bacterial lipopolysaccharide unequivocally identifies as fundamental mediator their induction. The different degrees defectiveness...