A5025930119- Hematopoietic Stem Cell Transplantation
- Thermodynamic and Structural Properties of Metals and Alloys
- Metallic Glasses and Amorphous Alloys
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Cardiac, Anesthesia and Surgical Outcomes
- T-cell and B-cell Immunology
- Theoretical and Computational Physics
- X-ray Diffraction in Crystallography
- Acute Lymphoblastic Leukemia research
- High-pressure geophysics and materials
- Mast cells and histamine
- Anesthesia and Pain Management
- Cytomegalovirus and herpesvirus research
- Virus-based gene therapy research
- Hemodynamic Monitoring and Therapy
- Parallel Computing and Optimization Techniques
- Material Dynamics and Properties
- Erythrocyte Function and Pathophysiology
- CAR-T cell therapy research
- Magnetic properties of thin films
- Anesthesia and Sedative Agents
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Phase-change materials and chalcogenides
Unfallkrankenhaus Salzburg
2016-2025
Paracelsus Medical University
2011-2024
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
2017-2024
Ludwig Boltzmann Institute for Digital Health and Prevention
2024
St Anna Children's Hospital
2010-2023
St. Anna Children's Cancer Research Institute
1997-2023
Medical University of Vienna
2013-2019
Ghent University Hospital
2011-2018
University of Alabama at Birmingham
2018
Lithuanian University of Health Sciences
2018
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of central nervous system young children, suggesting a cooperation between genetics and cellular context tumorigenesis. Although H3K27M-glioma are well characterized, their architecture remains uncharted. We performed single-cell RNA sequencing 3321 cells from six primary matched models. found that contain resemble oligodendrocyte precursor (OPC-like), whereas more differentiated malignant...
The purpose of this update the European Society Anaesthesiology (ESA) guidelines on pre-operative evaluation adult undergoing noncardiac surgery is to present recommendations based available relevant clinical evidence. Well performed randomised studies topic are limited and therefore many rely a large extent expert opinion may need be adapted specifically healthcare systems individual countries. This article aims provide an overview current knowledge subject with assessment quality evidence...
ABSTRACT Preclinical animal studies precede the majority of clinical trials. While definitions sepsis and recommended treatments are regularly updated, a systematic review preclinical models has not been done clear modeling guidelines lacking. To address this deficit, Wiggers-Bernard Conference on was held in Vienna May, 2017. The goal conference to identify limitations propose set guidelines, defined as “ Minimum Quality Threshold Sepsis Studies ” (MQTiPSS), enhance translational value...
A current hypothesis holds that chromatin fragmentation into oligonucleosomal patterns is an early event during apoptosis. In contrast, induction of apoptosis in cultured hepatocytes by TGF-beta 1 was not associated with DNA oligonucleosomes hepatocyte monolayers and apoptotic fragments. For a more rigorous test the we performed number experiments. We compared nuclear changes resulting from those induced Ca2+, known activator endonuclease. The morphology Ca(2+)-treated nuclei different as...
The purpose of these guidelines on the preoperative evaluation adult non-cardiac surgery patient is to present recommendations based available relevant clinical evidence. ultimate aims are two-fold. First, we aim identify those patients for whom perioperative period may constitute an increased risk morbidity and mortality, aside from risks associated with underlying disease. Second, this should help us design strategies that reduce additional risks. Very few well performed randomised studies...
CD27, a tumor necrosis factor receptor family member, interacts with CD70 and influences T-, B- NK-cell functions. Disturbance of this axis impairs immunity memory generation against viruses including Epstein Barr virus (EBV), influenza, others. CD27 is commonly used as marker B cells for the classification B-cell deficiencies common variable immune deficiency. Flow cytometric immunophenotyping expression analysis on lymphoid was followed by capillary sequencing in index patients, their...
Research suggests that the addition of dexmedetomidine to local anesthetics can prolong peripheral nerve blocks; however, clinical safety data are limited, and interscalene blocks have not been studied. The present study was designed test hypothesis added ropivacaine would safely enhance duration analgesia without adverse effects when compared with alone.We conducted a single-center, prospective, randomized, triple-blind, controlled trial 62 patients undergoing elective shoulder surgery...
The diagnosis of systemic mastocytosis (SM) is based primarily on the histologic and immunohistochemical evaluation a bone marrow trephine biopsy specimen. Although mast cell (MC) specific antigens like tryptase chymase are detectable in routinely processed tissue, no markers that can be used to discriminate between normal neoplastic MCs yet available. We have investigated diagnostic value an antibody against CD25 for detection sections 73 patients with SM 75 control cases (reactive marrow,...
Chronic myeloid leukemia (CML) is a stem cell disease in which BCR/ABL promotes the survival of leukemic cells. Heme oxygenase-1 (HO-1) an inducible stress protein that catalyzes degradation heme and has recently been implicated regulation growth various neoplastic In present study, we analyzed expression role HO-1 CML As assessed by Northern Western blot analysis as well immunostaining, primary cells were found to express mRNA constitutive manner. Exposure these tyrosine kinase inhibitor...
Abstract Background CD33 (Siglec‐3) is becoming increasingly important as a target of antibody‐mediated therapy in acute myeloid leukaemia (AML). In normal myelopoiesis, expression restricted to advanced stages differentiation, whereas primitive stem cells do not express CD33. the present study, we asked whether leukaemic patients with AML Materials and methods A multicolour‐staining technique was applied 11 AML, progenitors defined CD34 + /CD38 − /CD123 cells. were purified by cell sorting...
<h3>Background and Objectives</h3> The influence of the type anesthesia on perioperative outcomes after bilateral total knee arthroplasty (BTKA) remains unknown. Therefore, we examined a large sample BTKA recipients, hypothesizing that neuraxial would favorably impact outcomes. <h3>Methods</h3> We identified patient entries indicating elective between 2006 2010 in national database; subgrouped them by anesthesia: general (G), (N), or combined neuraxial-general (NG); analyzed differences...
Background Laboratory tests, electrocardiogram ( ECG ) and chest X ‐rays still serve as part of the routine assessment before elective surgery in many institutions, even though there is little evidence their predictive value relating to perioperative complications. This study investigates correlation abnormal findings pre‐operative tests pathologic medical history with Methods Patients scheduled for a secondary care hospital were included this prospective cohort study. Abnormal significant...