A5081984497- Glioma Diagnosis and Treatment
- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- MicroRNA in disease regulation
- Neurofibromatosis and Schwannoma Cases
- RNA modifications and cancer
- Virology and Viral Diseases
- Hereditary Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- Hedgehog Signaling Pathway Studies
- Alzheimer's disease research and treatments
- Mosquito-borne diseases and control
- Peripheral Neuropathies and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Trace Elements in Health
- Neuroblastoma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Nerve injury and regeneration
- Ocular Oncology and Treatments
- Chromatin Remodeling and Cancer
University of Ljubljana
2013-2024
Croatian Science Foundation
2020
University Clinical Centre Maribor
2016
Ljubljana University Medical Centre
2000-2014
University of Pennsylvania
2014
Universitat de Barcelona
2014
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2014
Faculty (United Kingdom)
2014
Institució Catalana de Recerca i Estudis Avançats
2014
Medical University of Vienna
2010
A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 South and Central America the Caribbean. major concern associated with this is apparent increased incidence microcephaly fetuses born to mothers infected ZIKV. In report, we describe case an expectant mother who had a febrile illness rash at end first trimester pregnancy while she living Brazil. Ultrasonography performed 29 weeks gestation revealed calcifications fetal brain placenta. After requested termination...
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of central nervous system young children, suggesting a cooperation between genetics and cellular context tumorigenesis. Although H3K27M-glioma are well characterized, their architecture remains uncharted. We performed single-cell RNA sequencing 3321 cells from six primary matched models. found that contain resemble oligodendrocyte precursor (OPC-like), whereas more differentiated malignant...
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation characterization, including single-cell RNA-seq, of neocortical spinal cord neuroepithelial stem (NES) cells to model early human ZIKV-related neuropathogenesis. By analyzing NES cells, organotypic fetal brain slices, a ZIKV-infected micrencephalic brain, show that ZIKV infects both as well their homolog, radial glial (RGCs), causing...
We recently reported a novel neurological syndrome characterized by unique NREM and REM parasomnia with sleep apnea stridor, accompanied bulbar dysfunction specific association antibodies against the neuronal cell-adhesion protein IgLON5. All patients had HLA-DRB1*1001 HLA-DQB1*0501 alleles. Neuropathological findings in two revealed tauopathy restricted to neurons predominantly involving hypothalamus tegmentum of brainstem. The aim current study is describe neuropathological features...
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years age, and carried out histologic review, methylation profiling, custom panel, genome, or exome sequencing. After excluding tumors representing other established entities subgroups, we identified 130 to be part an "intrinsic" spectrum disease specific infant...
Since precise diagnostic criteria for atypical and malignant meningiomas (AMMs) were provided the first time in 2000 World Health Organization (WHO) criteria, there is only sparse information about possible prognostic factors group of AMMs.To evaluate significance various histological clinical parameters AMMs, with an emphasis on location, mitotic count, brain invasion, Ki67 labeling index.We analyzed 86 primary 76 which 10 malignant, diagnosed according to WHO classification. Multivariate...
Current methods for diagnosing transmissible spongiform encephalopathies rely on the degradation of cellular prion protein (PrPC) and subsequent detection protease-resistant remnant pathological isoform PrPSc by antibodies that react with all forms PrP. We report a monoclonal antibody, V5B2, raised against peptide from C-terminal part PrP, which recognizes an epitope specific to PrPSc. In cryostat sections Creutzfeldt-Jacob's disease (CJD) patients' brains, V5B2 selectively labels various...
In spite of significant improvement after multi-modality treatment, prognosis most patients with glioblastoma remains poor. Standard clinical prognostic factors (age, gender, extent surgery and performance status) do not clearly predict long-term survival. The aim this case-control study was to evaluate immuno-histochemical genetic characteristics the tumour as additional in glioblastoma.Long-term survivor group were 40 survival longer than 30 months. Control shorter matched according...
Context.—The 2015 outbreak of Zika virus in Brazil resulted a 20-times increased prevalence congenital microcephaly stillborns and neonates was instrumental raising the suspicion causal association between microcephaly. Objective.—To provide comprehensive description neuropathologic features infection. Design.—Autopsy evaluation brain from fetus 32 weeks 6 days gestation, with prenatal diagnosis associated polymerase chain reaction–confirmed, fetal, Results.—Multiple severe pathology...
OTX1 and OTX2 are transcription factors with an essential role in the development of cerebellum. We previously described a high expression medulloblastoma. Here, we analyzed amplification mRNA series human medulloblastomas. In addition, protein was on tissue arrays. The gene amplified medulloblastoma cell line D425 data showed 114 152 medulloblastomas (75%), but not postnatal Northern blot (n = 10) reverse transcriptase-polymerase chain reaction 45) analyses demonstrated that virtually all...
The study aimed to characterize curcumin (CCM) (fluorescent yellow curry pigment) labeling of neuronal fibrillar tau inclusions (FTIs) in representative cases 3 main tauopathies: Alzheimer disease (AD), progressive supranuclear palsy, and Pick disease. After identification FTIs hematoxylin eosin-stained brain sections, sequential signal colocalization image analysis were used compare CCM with thioflavine S (ThS), monoclonal antibody AT8 immunofluorescence, Gallyas silver staining by...
Despite the important prognostic value of brain invasion in meningiomas, little attention has been paid to its massessment, and parameters associated with assessability (identification tissue surgical specimen) are not well characterized. The aim our study was determine that meningiomas.By binary logistic regression analysis, we studied association various clinical pathologic assessabilitym 294 meningiomas: 149 unselected consecutive meningiomas extensive sampling, diagnosed 2009 2010,...
Members of a Roma (Gypsy) family with hereditary motor and sensory peripheral neuropathy (HMSN) concomitant auditory vestibular cranial neuropathies were identified in Kocevje, Slovenia. The illness begins childhood severe progressive disability the deafness is delayed until second decade. There are no symptoms dysfunction. structure consistent an autosomal recessive pattern inheritance genetic locus for disorder linked to same region chromosome 8q24 as other families HMSN from Lom, Bulgaria...
The study aimed to evaluate the fluorescent molecular-imaging probe 2-(1-{6-[(2-fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP) for its ability selectively and reproducibly label prion plaques in fixed, paraffin-embedded cerebellar sections from patients of confirmed Gerstmann-Sträussler-Scheinker disease, sporadic Creutzfeldt-Jacob disease (CJD) with kuru plaques, variant CJD (vCJD). FDDNP is a highly hydrophobic, viscosity-sensitive, solvent-sensitive, substance,...
Abstract Purpose: Medulloblastoma is the most common malignant embryonal brain tumor in children. The current clinical risk stratification to select treatment modalities not optimal because it does identify standard-risk patients with resistant disease or unknown number of high-risk who might be overtreated protocols. aim this study improve medulloblastoma by using expression multiple prognostic markers combination parameters. Experimental Design: Candidate were selected from literature...
Abstract The characteristic response of Schwann cells (SC) accompanies peripheral nerve injury and regeneration. To elucidate their role, the question whether or not regenerating axons can elongate across segments a devoid SC was investigated. Rat sciatic crushed so that continuity basal laminae interrupted. A segment about 15 mm long distal to crush either repeatedly frozen/thawed eliminate scalded by moist heat which, in addition, denatured proteins laminae, too. Both sensory motor grew...
Cysteine cathepsins play an important role in shaping the highly infiltrative growth pattern of human gliomas. We have previously demonstrated that activity cysteine is elevated invasive glioblastoma (GBM) cells vitro, part due to attenuation their endogenous inhibitors, cystatins. To investigate this relationship vivo, we established U87-MG xenografts non-obese diabetic (NOD)/severe combined immunodeficiency (SCID)-enhanced green fluorescent protein (eGFP) mice. Here, tumor correlated with...
Anti-IgLON5 disease is a unique condition that bridges autoimmunity and neurodegeneration. Since its initial description 10 years ago, an increasing number of autopsies has led to the observation broader spectrum neuropathologies underlying particular constellation clinical symptoms. In this study, we describe neuropathological findings in 22 patients with anti-IgLON5 from 9 different European centers. 15 (68%), observed hypothalamic brainstem-predominant tauopathy varying severity which...
Deposition of conformationally altered proteins prominently characterizes pathogenesis and pathomorphology a number neurodegenerative disorders. 2-(1-{6-[(2-[F-18]fluoroethyl) (methyl)amino]-2-naphthyl} ethylidene) malononitrile ([F-18]FDDNP), hydrophobic, viscosity-sensitive, solvent-sensitive, fluorescent imaging probe has been used with positron emission tomography to visualize brain pathology in the living Alzheimer disease (AD) patients. Its non-radiofluorinated analog FDDNP was shown...
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