A5102963210- Advanced MRI Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- MRI in cancer diagnosis
- Neuroblastoma Research and Treatments
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Elasticity and Material Modeling
- Ultrasound and Hyperthermia Applications
- Lanthanide and Transition Metal Complexes
- Cancer Research and Treatments
- Melanoma and MAPK Pathways
- Ultrasound Imaging and Elastography
- Radiopharmaceutical Chemistry and Applications
- Estrogen and related hormone effects
- Advanced NMR Techniques and Applications
- Cellular Mechanics and Interactions
- Angiogenesis and VEGF in Cancer
- Synthesis and biological activity
- Cancer-related Molecular Pathways
- Aortic aneurysm repair treatments
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
Cancer Research UK
2009-2025
Institute of Cancer Research
2016-2025
Lantheus Medical Imaging (United States)
2013-2024
Royal Jubilee Hospital
2024
University of British Columbia
2024
Victoria Heart Institute Foundation
2024
Royal Marsden NHS Foundation Trust
1997-2023
Emory University
2023
Health Foundation
2022
Frimley Health NHS Foundation Trust
2019-2022
Cancer organoids to model therapy response are miniature, three-dimensional cell culture models that can be made from primary patient tumors and studied in the laboratory. Vlachogiannis et al. asked whether such “tumor-in-a-dish” approaches used predict drug responses clinic. They generated a live organoid biobank patients with metastatic gastrointestinal cancer who had previously been enrolled phase I or II clinical trials. This allowed authors compare how actually responded Encouragingly,...
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years age, and carried out histologic review, methylation profiling, custom panel, genome, or exome sequencing. After excluding tumors representing other established entities subgroups, we identified 130 to be part an "intrinsic" spectrum disease specific infant...
Background— Positron-emission tomography (PET) tracers for myocardial perfusion are commonly labeled with short-lived isotopes that limit their widespread clinical use. 18 F-BMS-747158-02 ( F-BMS) is a novel pyridaben derivative was evaluated assessment of by comparison 13 N-ammonia NH 3 ) and radioactive microspheres in pig model. Methods Results— Fourteen pigs injected 500 MBq or 100 to 200 F-BMS underwent dynamic PET at rest during pharmacological stress. In 8 these pigs, stress combined...
Background— Time-dependent activation of matrix metalloproteinases (MMPs) after myocardial infarction (MI) contributes to adverse left ventricular (LV) remodeling; however, noninvasive methods monitor this process serially are needed. Methods and Results— MMP-targeted radiotracers were developed that displayed selective binding kinetics the active MMP catalytic domain. Initial nonimaging studies performed with a 111 In-labeled radiotracer ( In-RP782) negative control compound In-RP788) in...
We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis relapse. Combined MYC family amplifications P53 pathway defects commonly emerged relapse, all patients in this group died rapidly progressive disease postrelapse. To study interaction, we investigated transgenic model MYCN-driven found spontaneous development Trp53 inactivating mutations. Abrogation p53 function produced aggressive tumors that mimicked characteristics...
Real-time detection of the rates metabolic flux, or exchange endogenous enzymatic reactions, is now feasible in biological systems using Dynamic Nuclear Polarization Magnetic Resonance. Derivation reaction rate kinetics from this technique typically requires multi-compartmental modeling dynamic data, and results are therefore model-dependent prone to misinterpretation. We present a model-free formulism based on ratio total areas under curve (AUC) injected product metabolite, for example...
PET allows for quantitative, regional myocardial perfusion imaging. The short half-lives of the tracers currently in use limit their clinical applicability. Here, biodistribution and imaging quality a new <sup>18</sup>F-labeled agent (<sup>18</sup>F-BMS-747158-02) an animal model are described. <b>Methods:</b> <sup>18</sup>F-BMS-747158-02 was determined at 10 60 min after injection. first-pass extraction fraction tracer measured isolated rat hearts perfused with Langendorff method....
There is a clinical need for noninvasive biomarkers of tumor hypoxia prognostic and predictive studies, radiotherapy planning, therapy monitoring. Oxygen-enhanced MRI (OE-MRI) an emerging imaging technique quantifying the spatial distribution extent oxygen delivery in vivo. In OE-MRI, longitudinal relaxation rate protons (ΔR1) changes proportion to concentration molecular dissolved plasma or interstitial tissue fluid. Therefore, well-oxygenated tissues show positive ΔR1. We hypothesized that...
Malignant tumors are typically associated with altered rigidity relative to normal host tissue. Magnetic resonance elastography (MRE) enables the noninvasive quantitation of mechanical properties deep-seated tissue following application an external vibrational stress that In this preclinical study, we used MRE quantify (kPa) elasticity modulus Gd and viscosity Gl three intracranially implanted glioma breast metastatic tumor models. all these brain tumors, found a notable softness...
Abstract The sensitivity of blood oxygenation level dependent (BOLD) contrast techniques to changes tumour deoxyhaemoglobin concentration is relevance many strategies in cancer treatments. In the context studies, which frequently involve use agents modify flow, there are underlying physiological different those BOLD brain. Hence we term, flow and (FLOOD) contrast, emphasize this difference importance effects. We have measured R 2 * a prolactinoma model for variety vasoactive challenges...
Abstract Purpose To investigate the physiological origins responsible for varying blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI) responses to carbogen (95% O 2 /5% CO ) breathing observed with different tumor types. Materials and Methods Susceptibility contrast‐enhanced MRI using exogenous pool contrast agent NC100150 determine volume vessel size, immunohistochemical‐derived morphometric parameters, were determined in GH3 prolactinomas RIF‐1 fibrosarcomas, both...