Matija Snuderl
A5078452073- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Neuroblastoma Research and Treatments
- Chromatin Remodeling and Cancer
- Meningioma and schwannoma management
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Immune cells in cancer
- Brain Metastases and Treatment
- Ferroptosis and cancer prognosis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ovarian cancer diagnosis and treatment
- Cancer Cells and Metastasis
- Microtubule and mitosis dynamics
- Hedgehog Signaling Pathway Studies
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Angiogenesis and VEGF in Cancer
- Head and Neck Surgical Oncology
- Cell Image Analysis Techniques
NYU Langone Health
2016-2025
New York University
2016-2025
Hinge Health
2020-2025
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2017-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2024
Memorial Sloan Kettering Cancer Center
2017-2024
S.P.E.C.I.E.S.
2024
Universitätsklinikum Erlangen
2024
Bellevue Hospital Center
2024
Cancer Support Community
2024
Metastatic cancer cells (seeds) preferentially grow in the secondary sites with a permissive microenvironment (soil). We show that metastatic can bring their own soil--stromal components including activated fibroblasts--from primary site to lungs. By analyzing efferent blood from tumors, we found viability of circulating is higher if they are incorporated heterotypic tumor-stroma cell fragments. Moreover, these cotraveling stromal provide an early growth advantage accompanying Consistent...
The stress harbored by the solid phase of tumors is known as stress. Solid can be either applied externally surrounding normal tissue or induced tumor itself due to its growth. Fluid pressure isotropic exerted fluid phase. We recently showed that growth-induced on order 1.3 13.0 kPa (10-100 mmHg)--high enough cause compression fragile blood vessels, resulting in poor perfusion and hypoxia. However, evolution with progression effect cancer cell proliferation vivo not understood. To this end,...
The prognosis of patients with glioblastoma (GBM) remains dismal, a median survival approximately 15 months. Current preclinical GBM models are limited by the lack "normal" human microenvironment and inability many tumor cell lines to accurately reproduce biology. To address these limitations, we have established model system whereby can retro-engineer patient-specific GBMs using patient-derived glioma stem cells (GSCs) embryonic (hESC)-derived cerebral organoids. Our organoid (GLICO) shows...
Abstract Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents children. They represent a morphologically heterogeneous class of some entities lack defining histopathological features. Therefore, the diagnosis sarcomas is burdened with high inter-observer variability misclassification rate. Here, we demonstrate classification using machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma trained dataset 1077 profiles from...
Abstract Purpose: Lower-grade gliomas (WHO grade II/III) have been classified into clinically relevant molecular subtypes based on IDH and 1p/19q mutation status. The purpose was to investigate whether T2/FLAIR MRI features could distinguish between lower-grade glioma subtypes. Experimental Design: scans from the TCGA/TCIA lower database (n = 125) were evaluated by two independent neuroradiologists assess (i) presence/absence of homogenous signal T2WI; (ii) “T2–FLAIR mismatch” sign; (iii)...
B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements, also known as “double-hit” (DHL), are rare neoplasms characterized by highly aggressive clinical behavior, complex karyotypes, a spectrum of pathologic features overlapping Burkitt lymphoma (BL), diffuse large (DLBCL) B-lymphoblastic lymphoma/leukemia (B-LBL). The this entity, including comparison to other high-grade neoplasms, has not been well defined. We conducted retrospective analysis 20 cases DHL seen at our institution...
Significance Improving survival of patients with glioblastoma (GBM) using antiangiogenic therapy remains a challenge. In this study we show that dual blockade angiopoietin-2 and vascular endothelial growth factor delays tumor enhances benefits through reprogramming tumor-associated macrophages toward an antitumor phenotype as well by pruning immature vessels. The immunomodulatory potential supports clinical testing approach for GBM other immunotherapeutic approaches such checkpoint blockers.
Antiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of the mechanisms action antiangiogenic agents hindered optimization broader application this new therapeutic modality. In particular, impact on blood flow oxygenation status (i.e., role vessel pruning versus normalization) remains controversial. This controversy become critical as multiple phase III trials anti-VEGF combined with cytotoxics failed to...
Purpose BRAF V600E is a potentially highly targetable mutation detected in subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group tumors remains unknown. Patients Methods A combined genetic institutional study patients with PLGGs long-term follow-up was performed (N = 510). Clinical treatment data mutated PLGG (n 99) were compared large international independent cohort mutated-PLGG 180). Results 69 405 (17%) across broad spectrum histologies...
Quantitative SRS microscopy can detect human brain tumor infiltration with high sensitivity and specificity, even in tissues appearing grossly normal.
Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the benefits receptor (VEGFR) treatment in murine GBM models and circulating Ang-2 levels patients rebound after an initial decrease following cediranib (a pan-VEGFR tyrosine kinase inhibitor) administration. Here we tested whether dual inhibition VEGFR/Ang-2 could improve survival two orthotopic GBM, Gl261 U87. Dual therapy using...
A first-in-human phase 1 clinical trial of the PEGylated protease-activated fluorescent probe, LUM015, enables tumor imaging at a safe and tolerable dose in humans.
Significance Emerging evidence indicates patients who benefit from antiangiogenic therapies have improved vessel function. To determine how bevacizumab modulates morphology to improve function we conducted a phase II trial of preoperative followed by combined with chemotherapy in HER2-negative breast cancer patients. Our results suggest that the clinical response may occur through an increase extent vascular normalization primarily high baseline tumor microvessel density. If validated, these...
<h3>Objective:</h3> Because the d-2-hydroxyglutarate (D2HG) product of mutant isocitrate dehydrogenase 1 (IDH1<sup>mut</sup>) is released by tumor cells into microenvironment and structurally similar to excitatory neurotransmitter glutamate, we sought determine whether IDH1<sup>mut</sup> increases risk seizures in patients with glioma, D2HG electrical activity neurons. <h3>Methods:</h3> Three WHO grade II-IV glioma cohorts from separate institutions (total N = 712) were retrospectively...
Antiangiogenic therapy is associated with increased radiographic responses in glioblastomas, but tumors invariably recur. Because tumor-associated macrophages have been shown to mediate escape from antiangiogenic preclinical models, we examined the role of patients recurrent glioblastoma. We compared autopsy brain specimens 20 glioblastoma who received treatment and chemoradiation 8 chemotherapy and/or radiotherapy without or no treatment. Tumor-associated were morphologically phenotypically...