A5102823671- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroscience and Neuropharmacology Research
- Diabetes Treatment and Management
- Advanced Breast Cancer Therapies
- Chronic Lymphocytic Leukemia Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Sedative Agents
- Healthcare Systems and Reforms
- Glioma Diagnosis and Treatment
- Global Health Care Issues
- Cancer Treatment and Pharmacology
- Spine and Intervertebral Disc Pathology
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Stress Responses and Cortisol
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Mechanisms and Therapy
- Metabolism, Diabetes, and Cancer
- Neurological Disease Mechanisms and Treatments
- Nanoparticle-Based Drug Delivery
- Sleep and related disorders
- Acute Myeloid Leukemia Research
- Botulinum Toxin and Related Neurological Disorders
Tianjin Medical University
2017-2024
Tianjin Third Central Hospital
2017-2024
Nankai University
2019-2024
National Cheng Kung University
2020-2024
Tianjin International Joint Academy of Biomedicine
2022-2024
Shihezi University
2024
University of California, Irvine
2022-2023
Zhejiang Chinese Medical University
2023
Neurological Surgery
2022-2023
Shanghai Normal University
2023
Cyclin-dependent kinase (CDK)4 and CDK6 are frequently overexpressed or hyperactivated in human cancers. Targeting CDK4/CDK6 combination with cytotoxic killing therefore represents a rational approach to cancer therapy. By selective inhibition of PD 0332991, which leads early G1 arrest synchronous S-phase entry upon release the block, we have developed novel strategy prime acute myeloid leukemia (AML) cells for by cytarabine (Ara-C). This sensitization is achieved part through enrichment...
Translesion synthesis (TLS) enables DNA replication through damaged bases, increases cellular damage tolerance, and maintains genomic stability. The sliding clamp PCNA the adaptor polymerase Rev1 coordinate switching during TLS. polymerases Pol η, ι, κ insert nucleotides opposite bases. ζ, consisting of catalytic subunit Rev3 regulatory Rev7, then extends past lesion. Here, we show that Rev7 binds to transcription factor TFII-I in human cells. is required for TLS tolerance. function appears...
Currently, most models of vascular cognitive impairment are established by occluding the carotid arteries uni- or bilaterally to reduce cerebral blood flow mimicking chronic hypoxia. Due sudden interruption, a gradual narrowing artery cannot be completely imitated. This paper aims establish bilateral stenosis model with mild dysfunction and white matter changes simulate patients predementia. Aged Wistar rats (18 months old) underwent either common (BCAS) occlusion (BCAO) surgery sham...
Abstract SPOP, an E3 ubiquitin ligase, acts as a prostate-specific tumor suppressor with several key substrates mediating oncogenic function. However, the mechanisms underlying SPOP regulation are largely unknown. Here, we have identified G3BP1 interactor of and functions competitive inhibitor Cul3 , suggesting distinctive mode inactivation in prostate cancer (PCa). Transcriptomic analysis functional studies reveal G3BP1-SPOP signaling axis that promotes PCa progression through activating AR...
In recent years, peer-assisted learning has emerged as a new and effective medical education modality. Near-peer tutoring utilizes senior student serving an instructor to junior student. 2019, the University of California, Irvine, School Medicine (UCISOM) implemented near-peer model beginning with first-year anatomy physiology curricula. Following successful pilot program, UCISOM launched full-fledged program in 2020 named Collaborative Learning Communities (CLC) Medical Students Teachers....
Importance Diabetic foot ulcers (DFUs) and subsequent amputation incur enormous health economic burdens to patients, care systems, societies. As a novel macrophage-regulating drug, ON101 is breakthrough treatment for DFUs, which demonstrated significant complete wound healing effects in phase 3 randomized clinical trial, but its value remains unknown. Objective To assess the cost-effectiveness of an cream added on general (GWC; ie, conventional treatments comprised initial regular...
Introduction Rapid and accurate detection of food-borne pathogens on mutton is great significance to ensure the safety its products health consumers. Objectives The feasibility short-wave infrared hyperspectral imaging (SWIR-HSI) in detecting contamination status species Escherichia coli (EC), Staphylococcus aureus (SA) Salmonella typhimurium (ST) contaminated was explored. Materials methods images uncontaminated samples with different concentrations (10 8 , 10 7 6 5 4 3 2 CFU/mL) EC, SA ST...
Elderly individuals undergoing surgical procedures are often confronted with the peril of experiencing postoperative cognitive dysfunction (POCD). Prior research has demonstrated exacerbating effect sevoflurane anesthesia on neuroinflammation, which can further deteriorate condition POCD in elderly patients. Intermittent fasting (IF) restricts food consumption to a specific time window and been ameliorate induced by neuropathic inflammation. We subjected 18-month-old male mice 16 hours 8...
RPK118 is a sphingosine kinase-1-binding protein that has been implicated in 1 phosphate-mediated signaling. It contains PX (phox homology) domain and two pseudo-kinase domains, co-localizes with kinase-1 on early endosomes. In this study we identified novel RPK118-binding protein, PRDX3 (peroxiredoxin-3), by yeast two-hybrid screening. The interaction between these proteins was confirmed pull-down assays co-immunoprecipitation experiments. Deletion studies showed interacted through its...
Glioma is life‑threatening tumor of the central nervous system. Although lidocaine usually used as local anesthetic, it also has antitumor effects. However, its clinical application in glioma hampered by limited distribution to brain. The aim present study was enhance ability penetrate blood‑brain barrier (BBB) target and investigate mechanism. A folic acid (FA)‑modified lidocaine‑carrying liposome (Lid‑FA‑Lip) prepared, particle size, ζ potential, encapsulation efficiency, release profile...
Oxidative stress enhances tumor invasion and metastasis in brain cancer. The activation of divalent metal transporter 1 (DMT1), which is regulated by glutamate receptors, can result the increase oxidative risk cancer development. Propofol, an anesthetic with antioxidant capacity, has been shown to decrease several different types However, underlying mechanism remains unclear. Therefore, present study aimed elucidate suppression glioma cells propofol. It was hypothesized that propofol may...
To examine the role of demographics on surgical management and inpatient complications in patients with spinal deformity between 2010 2014 via retrospective analysis.Data were obtained from National Inpatient Sample (NIS). International Classification Diseases 9th revision codes used to identify a primary diagnosis adult (ASD). Multivariable Poisson regression analyses determine whether any individual demographic variables predictive management, complexity, postoperative operations.17,433...
The ventrolateral preoptic area (VLPO) contains GABAergic sleep-active neurons. However, the extent to which these neurons are involved in expressing spontaneous sleep and homeostatic regulatory demands is not fully understood. We used calcium (Ca2+) imaging characterize activity dynamics of VLPO neurons, especially those vesicular GABA transporter (VGAT) across sleep-waking response demands. VLPOs wild-type VGAT-Cre mice were transfected with GCaMP6, Ca2+ fluorescence unidentified (UNID)...
Abstract Background Neurocognitive disorders (NCDs) and sleep disturbance are highly prevalent in the perioperative period intensive care unit (ICU). There has been a lack of individualized evaluation tools designed for high‐risk NCDs critically ill patients with disturbance. Objectives The aim this study was to develop validate prediction models among adult Methods R software used analyze dataset admitted ICU disturbance, who were diagnosed following codes International Classification...
Non-alcoholic fatty liver diseases (NAFLDs)/non-alcoholic steatohepatitis (NASH) are the most common disorders among patients with type 2 diabetes. Newer classes of glucose-lowering agents (GLAs), such as glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter inhibitors (SGLT2is), have been shown to improve liver-related biomarkers. However, their effects on development NAFLD/NASH remain inconclusive.