A5022264202- Mental Health Research Topics
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
- Digital Mental Health Interventions
- Neurological Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Natural Compound Pharmacology Studies
- Substance Abuse Treatment and Outcomes
- Natural product bioactivities and synthesis
- Amino Acid Enzymes and Metabolism
- Immune Cell Function and Interaction
- Inflammatory Bowel Disease
- Immunotherapy and Immune Responses
- Stress Responses and Cortisol
- Morinda citrifolia extract uses
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Biological and pharmacological studies of plants
- Cholangiocarcinoma and Gallbladder Cancer Studies
- COVID-19 and Mental Health
- Pancreatic and Hepatic Oncology Research
- Biochemical effects in animals
- Tryptophan and brain disorders
- Immune cells in cancer
- Impact of Technology on Adolescents
Yonsei University
2015-2024
Severance Hospital
2022
Kyung Hee University
2016
Whitehead Institute for Biomedical Research
2015
Massachusetts Institute of Technology
2015
Massachusetts General Hospital
2011-2012
Harvard University
2011
Objective This study evaluated the clinical effectiveness of Minds.NAVI, a depression screening kit combining psychometric measures and stress hormone biomarkers, in prospective trial. The objective was to assess its potential as tool investigate associations between psychological assessments, salivary staging, severity.Methods Thirty-five participants with major depressive disorder 12 healthy controls (HCs) were included. Minds.NAVI software, utilizing PROtective Vulnerable factors battEry...
Objective We aimed to elucidate public mental health problems and associated factors during the coronavirus disease-2019 (COVID-19). Furthermore, we evaluated people’s attitudes toward digital therapeutics pandemic.Methods Data was collected online from participants, aged between 20–50 without any history of illness, June 1st 30th 2021. The survey consisted questions regarding demographics, changes pandemic attitude towards therapeutics, measures.Results Among total 445 49.2% reported...
The excessive use of smartphones is associated with various medical complications and mental health problems. However, existing research findings on neurobiological mechanisms behind problematic smartphone are limited. In this study, we investigated functional connectivity in users, focusing the default mode network (DMN) attentional networks. We hypothesized that users would have alterations between DMN networks such correlate severity use. This study included 30 35 non-problematic users....
The association of Lewis antigen phenotype with survival patients pancreatic ductal adenocarcinoma was investigated.A total 1187 diagnosed were evaluated in a prospective cohort. Patients classified into 3 different groups according to phenotype: (1) A positive [Le(a+b-)], (2) B [Le(a-b+)], and (3) negative [Le(a-b-)]. Risk mortality analyzed Cox regression after adjusting for other predictors.The risk increased the order Le(a+b-), Le(a-b+), Le(a-b-) [reference; hazard ratio (HR), 1.27; 95%...
<sec> <title>BACKGROUND</title> Alcohol consumption is a leading cause of death and disability worldwide, associated with numerous acute chronic medical conditions. Digital health interventions offer promising solution to overcome barriers traditional treatment methods, providing accessible, scalable, cost-effective means support individuals in reducing hazardous drinking. </sec> <title>OBJECTIVE</title> This pilot study aims evaluate the feasibility, acceptability, preliminary efficacy...
Abstract Background Alcohol consumption is a leading cause of death and disability worldwide, associated with numerous acute chronic medical conditions. Digital health interventions offer promising solution to overcome barriers traditional treatment methods, providing accessible, scalable, cost-effective means support individuals in reducing hazardous drinking. Objective This pilot study aims evaluate the feasibility, acceptability, preliminary efficacy Sober smartphone app alcohol use....
Objectives : <TEX>$18{\beta}$</TEX>-Glycyrrhetinic acid (18betaGA) is an metabolite of glycyrrhizin in Glycyrrhiza (licorice). The present study investigated anti-inflammatory and anti-apoptosis effect 18betaGA on the brain tissue lipopolysaccharide (LPS)-treated C57BL/6 mice. Methods was administered orally with low (30 mg/kg) high (100 doses for 3 days prior to LPS (3 injection. Pro-inflammatory cytokines mRNA including tumor necrosis factor-<TEX>${\alpha}$</TEX>...
Objectives : Polygalae Radix (POL) has an ameliorating effect on learning and memory impairment caused by cerebral hypoperfusion. In regard to POL's action mechanism, this study was carried out investigate the effects of POL oxidative damage neuronal apoptosis induced hypoperfusion in rats.Methods The permanent bilateral common carotid artery occlusion (pBCAO) Sprague-Dawley rats. administered orally once a day (130 mg/kg water-extract) for 28 days starting at 4 weeks after pBCAO. Superoxide...
In the gastrointestinal tract, immune system must protect against potential pathogens whilst preventing destructive inflammatory responses to host commensal microlfora. This is achieved in part through a complex and active network of specialized cells regulatory cytokines. Breakdown this dynamic balance between response regulation likely be major contributor Inflammatory Bowel Disease. The importance populations lymphocytes maintaining intestinal homeostasis well established, but...
The maintenance of intestinal immune homeostasis involves a complex interplay between the luminal microbiota, barrier epithelial cells and system. Inflammatory bowel disease (IBD) is thought to arise from breakdown this mutual relationship dysregulation responses commensal bacteria. Although many studies have now established critical roles for both adaptive innate systems in process, how these two arms system work together remains poorly understood. We previously described role activation...
BackgroundThe maintenance of intestinal immune homeostasis involves a complex interplay between the luminal microbiota, barrier epithelial cells and system. Inflammatory bowel disease (IBD) is thought to arise from breakdown this mutual relationship dysregulation responses commensal bacteria. Although many studies have now established critical roles for both adaptive innate systems in process, how these two arms system work together remains poorly understood. We previously described role...