A5091766963- Neurological Disorders and Treatments
- Genomics, phytochemicals, and oxidative stress
- Neurological Disease Mechanisms and Treatments
- Retinal Imaging and Analysis
- Ginkgo biloba and Cashew Applications
- Cell death mechanisms and regulation
- Neuroblastoma Research and Treatments
- Thermoregulation and physiological responses
- Medicinal Plants and Neuroprotection
- Mental Health Research Topics
- NF-κB Signaling Pathways
- Spine and Intervertebral Disc Pathology
- Phytochemicals and Antioxidant Activities
- Fungal Biology and Applications
- Digital Mental Health Interventions
- ATP Synthase and ATPases Research
- Cardiovascular Health and Disease Prevention
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Substance Abuse Treatment and Outcomes
- Signaling Pathways in Disease
- Retinal and Optic Conditions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Retinal Diseases and Treatments
Severance Hospital
2014-2024
Yonsei University
2016-2024
Dong-A University
2023
Gyeongsang National University
2023
Pukyong National University
2016-2022
Institute of Behavioral Sciences
2022
Hallym University Medical Center
2014
Hyoja Geriatric Hospital
2013
Seoul St. Mary's Hospital
2013
Catholic University of Korea
2013
β-thymosin is known for having 43 amino acids, being water-soluble, a light molecular weight and ubiquitous polypeptide. The biological activities of are diverse include the promotion wound healing, reduction inflammation, differentiation T cells inhibition apoptosis. Our previous studies showed that oyster originated from mantle Pacific oyster, Crassostrea gigas had antimicrobial activity. In this study, we investigated anti-inflammatory effects in lipopolysaccharide (LPS)-induced RAW264.7...
Kaempferol‑3‑O‑β‑rutinoside is one of the compounds isolated from tartary buckwheat (Fagopyrum tatricum), and its biological effects have not been studied yet. The present study examined anti‑inflammatory kaempferol‑3‑O‑β‑rutinoside explore regulatory mechanisms in lipopolysaccharide (LPS)‑induced macrophage RAW264.7 cells. exhibited no cytotoxic effect RAW 264.7 293 cell lines up to 300 µM. As concentration was increased, activity nitric oxide inhibited LPS‑stimulated In addition, treatment...
Lovastatin is a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor that clinically used for the prevention of cardiovascular diseases. Although it has been reported lovastatin anti-inflammatory properties in several studies, how regulates inflammation still unclear. To evaluate effect on nitric oxide production (NO) RAW264.7 macrophages, NO assay was performed. Also, cell viability measured to confirm cytotoxicity. Level tumor necrosis factor-α (TNF-α) transcription by reverse polymerase...
Objective: To identify patterns of physical activity (PA) participation, exercise preference, and barriers stage 2-3 prostate cancer survivors across trajectories based on selected demographic medical variables.Design: The current study is a descriptive cross-sectional which included data from total 111 survivors, at Shinchon Severance Hospital, Seoul, Korea. survey includes PA levels before after diagnosis, barriers, preferences.Results: Moderate- to vigorous-intensity were significantly...
목적: 국내 로타바이러스 백신 도입 전후로 8년간 입원한 위장관염의 역학 및 임상 양상의 변화를 파악하고자 하였고, 최근 2년간 입원 환자를 대상으로 예방접종의 효과에 대하여 분석하였다. 방법: 2006년 1월부터 2013년 12월까지 급성 위장관염으로 5세 미만의 5,697명의 환아 중 항원 검사에 양성을 보인 1,165명의 연도 계절별추이를 그리고 2011년 12월부터 환아들 460명을 설문조사를 실시하여 접종 여부, 횟수, 증상 등에 파악하였고, 이들 항원검사에서 양성이 확인된 124명을 예방접종 시행 여부에 따른 검사실 결과를 비교 결과: 1) 연령별 분포는 2세미만의 환아가 전체의 64.5%를 차지하였다. 연도별 위장관염 발생 수는 2010년부터 급격히 감소하였다. 월별 2008년까지는 12월에 발생이 증가하기 시작하여 1-2월에 정점을 이루었으나, 2010년 이후로는 3-4월에 이루는 양상으로, 이후 로타바이러스의 활동의 시작, 계절적 정점이 늦춰지는 양상을...
The clinical benefits of nootropics in the treatment cognitive decline has been either limited or controversial. This study aimed to observe effectiveness cholinesterase inhibitor (ChEI) and combination impairment dementia. Data were based on electronic medical records a university health system. Patients with mild-to-moderate dementia no history prior enhancer use included (n = 583). subjects categorized into ChEI only group group. primary outcome measure was change function, as assessed by...
Among various types children's health challenges, neuroblastoma is the most serious solid neoplasm forming outside cranium. Scomberomorus niphonius a valuable edible fish that has been widely used for meal. In this study, we obtained phospholipid extract from bone of S. with supercritical CO2 extraction method and tested anticancer activity cell viability assay. The showed on SK-N-SH cells, was presented an IC50 710.25 ± 28.31 μg/ml, but did not show significant toxicity HUVEC lines. Western...
Axon regeneration is essential for successful recovery after peripheral nerve injury. Although growth cone reformation and axonal extension are crucial steps in regeneration, the regulatory mechanisms underlying these dynamic processes poorly understood. Here, we identify βPix (Arhgef7), guanine nucleotide exchange factor Rac1 GTPase, as a regulator of regeneration. After sciatic injury mice, expression levels increase significantly segments containing regenerating axons. In regrowing axons,...
The capsule endoscope, a new application area of digital imaging, is growing rapidly but needs the versatile imaging capabilities such as auto-focusing and zoom-in to be an active diagnostic tool. liquid lens based on MEMS technology can strong candidate because it able small enough. In this paper, cylinder-type was designed Young-Lippmann model then fabricated with combining silicon thin-film process wafer bonding process. focal length module including changed reproducibly function applied...
Inhibition of over‑activated inflammation has been demonstrated as one the most efficient strategies for treating inflammatory diseases. In present study, 6‑formyl umbelliferone (6FU) was used to evaluate its anti‑inflammatory effects on lipopolysaccharide (LPS)‑stimulated RAW 264.7 macrophages. 6FU inhibited chronic processes, including increasing nitric oxide levels, and expression pro‑inflammatory genes producing cytokines investigated by a nitrite assay reverse transcription‑polymerase...
Oh, Jeehae MD; Kang, Minjae Park, Joohye Lee, Jong In MD, PhD Author Information
Purpose: This study was done to identify the influence of severity drinking problem, circadian rhythm and sleep quality in patients with alcohol use. Methods: A descriptive design utilized. Data were collected using self-report questionnaires from 139 use disorder who admitted a psychiatric hospital D city, Korea. The included Alcohol Use Disorders Identification Test (AUDIT), Composite Scale Morningness (CMS), Pittsburgh Sleep Quality Index (PSQI), Korea scale A. analyzed statistics,...
Abstract Extracellular fluid (ECF) excess is common in patients with chronic kidney disease (CKD). This study (involving 284 CKD) explored the association between choroidal vascularity index (CVI) and ECF excess. We categorised into three groups based on extracellular water/total body water: normal, mildly overhydrated, severely overhydrated. The more severe status was associated a lower CVI after adjustment (B = − 0.902, p 0.001). In non-diabetic patients, both vascular luminal (LA, <...
<sec> <title>BACKGROUND</title> Alcohol consumption is a leading cause of death and disability worldwide, associated with numerous acute chronic medical conditions. Digital health interventions offer promising solution to overcome barriers traditional treatment methods, providing accessible, scalable, cost-effective means support individuals in reducing hazardous drinking. </sec> <title>OBJECTIVE</title> This pilot study aims evaluate the feasibility, acceptability, preliminary efficacy...
Abstract Background Alcohol consumption is a leading cause of death and disability worldwide, associated with numerous acute chronic medical conditions. Digital health interventions offer promising solution to overcome barriers traditional treatment methods, providing accessible, scalable, cost-effective means support individuals in reducing hazardous drinking. Objective This pilot study aims evaluate the feasibility, acceptability, preliminary efficacy Sober smartphone app alcohol use....
Introduction Ioxitalamate (Telebrix 300) is an ionic iodinated contrast medium (CM) commonly used for discography or PELD (percutaneous endoscopic lumbar discectomy), though it has side effects such as anaphylactic shock and renal toxicity. Indigocarmine organic compound dye with a distinctive blue color that during to stain the acidic, degenerated nucleus pulposus. Although ioxitalamate indigocarmine are widely in spinal surgery, there have been no reports on their pulposus (NP) cells. We...