A5032932081- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Fetal and Pediatric Neurological Disorders
- Advanced MRI Techniques and Applications
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Testicular diseases and treatments
- Cancer Genomics and Diagnostics
- Congenital Diaphragmatic Hernia Studies
- Infectious Diseases and Mycology
- Cancer, Hypoxia, and Metabolism
- Chromatin Remodeling and Cancer
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
- Brain Metastases and Treatment
- Renal and related cancers
- Ocular Oncology and Treatments
- MRI in cancer diagnosis
- Sinusitis and nasal conditions
- Infectious Encephalopathies and Encephalitis
- Teratomas and Epidermoid Cysts
St. Jude Children's Research Hospital
2013-2022
Cotton (United States)
2022
Dartmouth College
2021-2022
Dartmouth–Hitchcock Medical Center
2022
McMaster Children's Hospital
2017
American Lebanese Syrian Associated Charities
2017
The University of Texas Southwestern Medical Center
2010-2011
Duke University Hospital
2010
Duke Medical Center
2010
Duke University
2010
Purpose BRAF V600E is a potentially highly targetable mutation detected in subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group tumors remains unknown. Patients Methods A combined genetic institutional study patients with PLGGs long-term follow-up was performed (N = 510). Clinical treatment data mutated PLGG (n 99) were compared large international independent cohort mutated-PLGG 180). Results 69 405 (17%) across broad spectrum histologies...
Dysembryoplastic neuroepithelial tumors (DNETs) are uncommon neural presenting most often in children and young adults associated with intractable seizures. Rare midline neoplasms similar histological features to those found DNETs have been described near the septum pellucidum termed "DNET-like of pellucidum." Due their rarity, these just a few reports genetic alterations sought only small series. We collected 20 for comprehensive study clinical, radiological, pathological features. RNA...
Gangliogliomas are low-grade glioneuronal tumors of the central nervous system and commonest cause chronic intractable epilepsy. Most gangliogliomas (>70%) arise in temporal lobe, infratentorial account for less than 10%. Posterior fossa can have features a classic supratentorial tumor or pilocytic astrocytoma with focal gangliocytic differentiation, this observation led to hypothesis tested study - posterior spinal cord consist two morphologic types that be distinguished by specific genetic...
<h3>BACKGROUND AND PURPOSE:</h3> Posterior fossa syndrome is a severe postoperative complication occurring in up to 29% of children undergoing posterior tumor resection; it most likely caused by bilateral damage the proximal efferent cerebellar pathways, whose fibers contribute Guillain-Mollaret triangle. When triangle disrupted, hypertrophic olivary degeneration develops. We hypothesized that MR imaging patterns inferior nucleus changes reflect pathways and show association with clinical...
Tectal glioma (TG) is a rare low-grade tumor occurring predominantly in the pediatric population. There has been no detailed analysis of molecular alterations TG. Risk factors associated with inferior outcome and long-term sequelae TG have not well-documented. We retrospectively studied TGs treated or referred for review at St. Jude Children's Research Hospital (SJCRH) between 1986 2013. Longitudinal clinical data were summarized, imaging pathology specimen centrally reviewed, material...
The authors find that when measured in terms of dollar-turnover, and once β low volatility (low-vol) neutralized, the size effect is alive well. With a long-term <i>t</i>-statistic 5.1, <i>cold-minus-hot</i> (CMH) anomaly certainly not less significant than other well-known factors such as value or quality. As compared to market-cap-based SMB, report CMH portfolios are much anti-correlated low-vol anomaly. In contrast with standard risk premiums, size-based found by be virtually unskewed....
<h3>SUMMARY:</h3> PT promises to reduce side effects in children with brain tumors by sparing normal tissue compared 3D conformal or intensity-modulated radiation therapy. Information is lacking about the combined of and chemotherapy young children. We describe imaging changes 8 very localized who received after chemotherapy. Mostly transient signal abnormalities enhancement parenchyma were observed serial MR imaging, which consistent radiation-induced on normal-appearing tissue. Correlation...
Treatment of pediatric medulloblastoma is associated with known neurocognitive deficits that we hypothesize are caused by microstructural damage to frontal white matter (WM).Longitudinal MRI examinations were collected from baseline (after surgery but before therapy) 36 months in 146 patients and at 3 time points 72 controls. Regional analyses WM volume diffusion tensor imaging metrics performed verified tract-based spatial statistics. Age-adjusted, linear mixed-effects models used compare...
<h3>SUMMARY:</h3> Lenticulostriate aneurysms are rare and usually present with intracranial hemorrhage, limiting understanding of their natural course. We describe an unusual case unruptured rapidly growing distal LSA aneurysm in the setting Moyamoya disease, successfully embolized <i>n</i>-BCA following functional neurologic testing amobarbital.
Management of unresectable pediatric low-grade glioma and glioneuronal tumor (LGG/LGGNT) is controversial. There are no validated prognostic features to guide use radiation therapy (RT). Our study aimed identify negative in patients treated with RT using clinicopathologic molecular data validate these findings an external dataset.Children non-metastatic, biopsy-proven LGG/LGGNT at a single institution between 1997 2017 were identified. Recursive partitioning analysis (RPA) was used stratify...
<h3>BACKGROUND AND PURPOSE:</h3> Postoperative intraspinal subdural collections in children after posterior fossa tumor resection may temporarily hinder metastasis detection by MR imaging or CSF analysis, potentially impacting therapy. We investigated the incidence, and clinical features, predisposing factors, time course of these resection. <h3>MATERIALS METHODS:</h3> Retrospective review postoperative spine MRI 243 (5.5 ± 4.6 years age) from our data base postresection tumors October 1994...
<h3>SUMMARY:</h3> Trichothiodystrophy (TTD) is a rare group of autosomal recessive disorders DNA repair unified by the presence sulfur-deficient brittle hair. We report 3-year-old boy with classic clinical features TTD, including ichthyosis, alopecia, developmental delay, and tiger-tail banding hair shaft on polarizing microscopy. Brain MR imaging showed both diffuse dysmyelination osteosclerosis, findings that, in combination, may be specific for TTD.
Background Approximately 30% of patients with metastatic (stage M) neuroblastoma present periorbital ecchymosis from orbital osseous disease. Though locoregional disease is staged by imaging, the prognostic significance site in stage M unknown. We hypothesize that, compared to nonorbital metastasis, metastasis associated decreased survival neuroblastoma, and that reflects location extent Procedure Medical records imaging 222 seen at St. Jude Children's Research Hospital between January 1995...
Isolated optic nerve glioma is a rare tumor with no consensus for the best therapeutic approach. Therefore, control and preservation of visual function remain challenge. In this retrospective study, we describe our experience over 30 years in single-institutional cohort children isolated glioma, focusing on treatments outcomes. Seventeen were followed median period 8 (range, 2-22 years). Diagnosis was based typical neuroradiologic findings, 3 patients had histologic confirmation their...