A5065646270- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Cancer-related cognitive impairment studies
- Childhood Cancer Survivors' Quality of Life
- Hemoglobinopathies and Related Disorders
- Fetal and Pediatric Neurological Disorders
- Acute Lymphoblastic Leukemia research
- Iron Metabolism and Disorders
- Functional Brain Connectivity Studies
- Bone and Joint Diseases
- Pituitary Gland Disorders and Treatments
- Medical Image Segmentation Techniques
- Ocular Oncology and Treatments
- Epilepsy research and treatment
- Advanced NMR Techniques and Applications
- NMR spectroscopy and applications
- Cerebrospinal fluid and hydrocephalus
- Brain Tumor Detection and Classification
- Spinal Dysraphism and Malformations
- Radiomics and Machine Learning in Medical Imaging
- Atomic and Subatomic Physics Research
- Genetics and Neurodevelopmental Disorders
- Lanthanide and Transition Metal Complexes
- Anesthesia and Sedative Agents
St. Jude Children's Research Hospital
2012-2024
Larkin Community Hospital
2023
Children's National
2015
George Washington University
2015
Mayo Clinic
2013
First Hospital of Jilin University
2013
Jilin University
2013
University of Portsmouth
2013
Washington University in St. Louis
2013
Duke Medical Center
2013
We introduce a fast and robust spatial-spectral encoding method, which enables acquisition of high resolution short echo time (13 ms) proton spectroscopic images from human brain with times as 64 s when using surface coils. The scheme, was implemented on clinical 1.5 Tesla whole body scanner, is modification an echo-planar imaging method originally proposed by Mansfield Magn. Reson. Med. 1, 370-386 (1984), utilizes series read-out gradients to simultaneously encode spatial spectral...
Posterior fossa syndrome is characterized by cerebellar dysfunction, oromotor/oculomotor apraxia, emotional lability and mutism in patients after infratentorial injury. The underlying neuroanatomical substrates of posterior are unknown, but dentatothalamocortical tracts have been implicated. We used pre- postoperative neuroimaging to investigate proximal tract involvement childhood embryonal brain tumour who developed following resection. Diagnostic imaging from a cohort 26 paediatric...
Children receiving CNS-directed therapy for cancer are at risk cognitive problems, with few available empirically supported interventions. Cognitive problems indicate neurodevelopmental disruption that may be modifiable intervention. This study evaluated short-term efficacy of a computerized training program and neural correlates change.A total 68 survivors childhood acute lymphoblastic leukemia (ALL) or brain tumor (BT) identified deficits were randomly assigned to intervention (male, n =...
To examine associations among methotrexate pharmacodynamics, neuroimaging, and neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on a contemporary chemotherapy-only protocol.This longitudinal study linked pharmacokinetic assays collected during therapy to brain imaging follow-up. A total 218 (72.2%) 302 eligible were recruited for outcome studies when they more than 5 years post-diagnosis older 8 age. At follow-up, an average 13.8 old 7.7 from...
Conformal radiation therapy (CRT) aims to limit the highest dose tissue volume at risk while sparing surrounding normal tissues. This study investigated whether treatment of childhood ependymoma with CRT would preserve cognitive function. Academic competence was chosen as primary outcome measure given it is a applied abilities in child's natural setting.Eighty-seven pediatric patients diagnosed received which doses ranging from 54.0 59.4 Gy were prescribed postoperative tumor bed 10-mm...
Cranial radiotherapy (CRT) is a known risk factor for neurocognitive impairment in survivors of childhood cancer and may increase mild cognitive dementia adulthood. We performed cross-sectional evaluation acute lymphoblastic leukemia (ALL) treated with 18 Gy (n = 127) or 24 138) CRT. Impairment (age-adjusted score >1 standard deviation below expected mean, two-sided exact binomial test) on the Wechsler Memory Scale IV (WMS-IV) was measured. A subset 85) completed structural functional...
Survivors of childhood acute lymphoblastic leukaemia are at risk for neurocognitive impairment, though little information is available on its association with brain integrity, particularly survivors treated without cranial radiation therapy. This study compares function and morphology in long-term adult chemotherapy alone (n = 36) to those therapy 39) healthy control subjects 23). Mean (standard deviation) age evaluation was 24.9 (3.6) years the group 26.7 (3.4) group, while time since...
Children treated for posterior fossa tumors experience reduced cognitive processing speed and, after imaging, show damage to white matter (WM) tracts in the brain. This study explores relationships between microstructure, assessed by fractional anisotropy (FA), and of using tract-based spatial statistics (TBSS). At 36 months treatment with radiotherapy chemotherapy, 40 patients completed an MRI examination neuropsychological evaluation. Patients were matched healthy control subjects based on...
Both physiological and imaging approaches have led to often-disparate conclusions about the organization of taste information in gustatory cortex (GC). In this study, we used neuroanatomical delineate likely area insular given function characterize responses within delineated female male C57BL/6J mice. Anterograde tracers were injected into thalamus (the medial parvicellular portion ventral posterior division, VPMpc) mice thalamic terminal field was investigated across cortex. Working area,...
A new rapid spectroscopic imaging technique with improved sensitivity and lipid suppression, referred to as Proton Echo Planar Spectroscopic Imaging (PEPSI), has been developed measure the 2-dimensional distribution of brain lactate increases during hyperventilation on a conventional clinical scanner equipped head surface coil phased array. PEPSI images (nominal voxel size: 1.125 cm3) in five healthy subjects from an axial section approximately 20 mm inferior intercommissural line were...
Abstract Age‐related changes in brain T 1 from 115 healthy subjects (range, 4.5–71.9 yr) were analyzed relation to published regional iron concentration cortex, caudate, putamen, and frontal white matter. The relaxation rate these struc tures was linear with respect ( P < 0.001). relaxivity, k (s −1 /mg iron/g wet weight), much higher cortex (5.5) matter (6.1) than caudate (1.7) putamen (1.0). These results are consistent evidence that is an important factor determining the properties of...
Abstract While longitudinal studies of children treated for brain tumors have consistently revealed declines on measures intellectual functioning, greater specification cognitive changes following treatment is imperative isolating vulnerable neural systems and developing targeted interventions. Accordingly, this cross-sectional study evaluated the performance childhood tumor survivors ( n = 50) with conformal radiation therapy, solid 40) who had not received central nervous system (CNS)...
Objective To investigate the long-term efficacy of computerized cognitive training in improving outcomes among childhood cancer survivors. Methods Sixty-eight survivors acute lymphoblastic leukemia (ALL) or brain tumor (BT) were randomly assigned to intervention (23 ALL/11 BT, age = 12.21 ± 2.47) a waitlist control group (24 ALL/10 11.82 2.42). Cognitive assessments completed pre-, immediately post-, and 6 months postintervention. Results A prior report showed led immediate improvement...
Introduction: N-back tasks are commonly used in functional neuroimaging studies to identify the neural mechanisms supporting working memory (WM). Despite widespread use, clinical utility of these is not well specified. This study compared performance during magnetic resonance imaging (fMRI) with task data acquired outside scanner as a measure reliability across environment. validity was examined relation and rater-based measures clinically assess memory. Method: Forty-three healthy adults...
Spin-lattice (T1) relaxation times were measured by an inversion-recovery magnetic resonance imaging method with a slice-selective inversion pulse (SIP), non-selective rectangular (RIP), or B1-insensitive adiabatic (AIP). Data analysis either assumed perfect (two-parameter fit) allowed for imperfect (three-parameter fit). Imperfect pulses caused low T1 values in phantoms two-parameter fit, while three-parameter estimates accurate over the range 430–2670 ms. A difference of ∼10% between and...