A5053211194- Cancer-related cognitive impairment studies
- Childhood Cancer Survivors' Quality of Life
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Cancer Treatment and Pharmacology
- Vestibular and auditory disorders
- Intensive Care Unit Cognitive Disorders
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Family Support in Illness
- Ocular Oncology and Treatments
- Neuroblastoma Research and Treatments
- Peripheral Nerve Disorders
- Retinal Development and Disorders
- Pediatric Pain Management Techniques
- Radiation Therapy and Dosimetry
- Spinal Dysraphism and Malformations
- Anesthesia and Sedative Agents
- Ophthalmology and Eye Disorders
- Brain Metastases and Treatment
- Nutrition, Genetics, and Disease
- Analog and Mixed-Signal Circuit Design
- Intracerebral and Subarachnoid Hemorrhage Research
St. Jude Children's Research Hospital
2008-2024
Juno Therapeutics (Germany)
2018
Pfizer (United Kingdom)
2018
Gilead Sciences (Germany)
2018
Medtronic (United States)
2018
Cytokinetics (United States)
2018
Incyte (United States)
2018
Alpine Immune Sciences (United States)
2018
Vanderbilt University
2015
Northwestern University
2012
Posterior fossa syndrome is characterized by cerebellar dysfunction, oromotor/oculomotor apraxia, emotional lability and mutism in patients after infratentorial injury. The underlying neuroanatomical substrates of posterior are unknown, but dentatothalamocortical tracts have been implicated. We used pre- postoperative neuroimaging to investigate proximal tract involvement childhood embryonal brain tumour who developed following resection. Diagnostic imaging from a cohort 26 paediatric...
Purpose Childhood cancer survivors are at increased risk of subsequent neoplasms (SNs), but the germline genetic contribution is largely unknown. We assessed pathogenic/likely pathogenic (P/LP) mutations in predisposition genes to their SN risk. Patients and Methods Whole-genome sequencing (30-fold) was performed on samples from childhood who were ≥ 5 years since initial diagnosis participants St Jude Lifetime Cohort Study, a retrospective hospital-based study with prospective clinical...
<h3>Importance</h3> Limited studies have reported associations between anesthesia and neurocognitive neuroimaging outcomes, particularly in pediatric patients who undergo multiple exposures to as part of chronic disease management. <h3>Objective</h3> To investigate whether general is associated with impairment abnormalities long-term survivors childhood acute lymphoblastic leukemia. <h3>Design, Setting, Participants</h3> A cohort study 212 leukemia received treatment July 7, 2000, November...
Long-term survivors of childhood cancer may be at elevated risk for new neurocognitive impairment and decline as they age into adulthood.
Chemotherapeutic agents used to treat acute lymphoblastic leukemia (ALL), the most common cancer affecting young children, have been associated with long-term cognitive impairments that reduce quality of life. Executive dysfunction is one consistently observed deficits and can substantial pervasive effects on academic success, occupational achievement, psychosocial function, psychiatric status. We examined neural mechanisms executive by measuring structural functional connectomes in 161...
Background Survivors of childhood acute lymphoblastic leukemia (ALL) are at increased risk for both treatment‐related exercise intolerance and neurocognitive deficits. This analysis aimed to identify the association between impairments in ALL survivors. Methods Cardiopulmonary testing, results from a 2‐hour standardized neuropsychological assessment, self‐report questionnaires were obtained 341 adult survivors 288 controls. Multivariable modeling was used test associations oxygen uptake 85%...
Abstract Survivors of childhood acute lymphoblastic leukemia (ALL) treated with chemotherapy only are at risk for neurocognitive impairment. Regions interest were identified a priori based on glucocorticoid receptor distribution, and sex‐stratified multivariable linear regression models used to test associations between brain MRI morphology total number intrathecal injections, serum concentration dexamethasone methotrexate. Compared controls, ALL survivors have persistently smaller volumes...
Hodgkin lymphoma (HL) survivors experience neurocognitive impairment despite receiving no central nervous system-directed therapy, though little is known about the underlying mechanisms.
Summary: The Wada test has historically been the conventional procedure for determining language lateralization before neurosurgery. However, functional magnetic resonance imaging (fMRI) offers a less invasive alternative to procedure. Research indicates that two techniques used together may provide comparable, and sometimes complementary, information results in improved prediction of postsurgical ability. We present case which use fMRI conjunction with testing provided complementary about...
Diffusion tensor (DT) imaging has been used to predict postoperative motor function in patients with supratentorial tumors. The authors sought determine whether DT and white matter tractography could detect axonal degeneration brainstem tumors.A cross-sectional, retrospective study of 7 tumors 8 healthy volunteers was performed. data were normalized regions interest (ROIs) the highest probability sensory connections selected using Talairach Atlas identify 3D millimetric coordinates tracts....
Brainstem gliomas are a heterogeneous group of lesions that account for 15% all pediatric tumors the central nervous system. Diagnosis and treatment planning these is based on observation Epstein Farmer growth with low malignant potential limited by anatomical structures brainstem. Surgery offered only to those patients high probability harboring low-grade tumor, because attendant risk significant morbidity outweighs therapeutic benefit debulking tumor in cases high-grade tumors. The authors...
Background The impact of growth hormone deficiency (GHD) on neurocognitive function is poorly understood in survivors childhood acute lymphoblastic leukemia (ALL). This study examined the contribution GHD to functional outcomes while adjusting for cranial radiation therapy (CRT). Methods Adult ALL (N = 571; 49% female; mean age, 37.4 years; age range, 19.4‐62.2 years) completed tests and self‐reported symptoms, emotional distress, quality life. was defined as a previous diagnosis or plasma...
Background The objective of this study was to determine the impact seizure‐related factors on neurocognitive, health‐related quality life (HRQOL), and social outcomes in survivors childhood cancer. Methods Survivors cancer treated at St. Jude Children's Hospital (n = 2022; 48.3% female; median age, 31.5 years; time since diagnosis, 23.6 years) completed neurocognitive testing questionnaires. presence, severity, resolution, treatment history seizures were abstracted from medical records....
Abstract Background Long-term survivors of pediatric acute lymphoblastic leukemia are at elevated risk for neurocognitive deficits and corresponding brain dysfunction. This study examined sex-based differences in functional neuroimaging outcomes treated with chemotherapy alone. Methods Functional magnetic resonance imaging (fMRI) testing were obtained 123 (46% male; median [min-max] age = 14.2 years [8.3-26.5 years]; time since diagnosis 7.7 [5.1-12.5 years]) on the St. Jude Total XV...
To use functional magnetic resonance imaging (fMRI) and diffusion tensor (DTI) to investigate visual system development in children being treated for retinoblastoma.Informed consent was obtained all participants (N = 42) this institutional review board-approved study. Participants were imaged with a 1.5-T scanner while under propofol sedation. Diagnostic brain orbital followed by investigational neuroimaging, which included fMRI during photic stimulation through closed eyelids, measure...
<h3>Importance</h3> Treatment with contemporary chemotherapy-only protocols is associated risk for neurocognitive impairment among survivors of childhood acute lymphoblastic leukemia (ALL). <h3>Objective</h3> To determine whether concurrent use methotrexate and glucocorticoids interference the antioxidant system brain damage disruption glucocorticoid-sensitive regions cerebello-thalamo-cortical network. <h3>Design, Setting, Participants</h3> This cross-sectional study was conducted from...
Background: Patients with breast cancer frequently report cognitive impairment both during and after completion of therapy. Evidence suggests that cancer-related impairments are related to widespread neural network dysfunction. The default mode (DMN) is a large conserved plays critical role in integrating the functions various systems. Disruption may play key development impairment. Methods: We compared neuroimaging neurocognitive data from 43 newly diagnosed primary patients (mean age = 48,...
Abstract Thoracic radiation is associated with significant cardiopulmonary morbidities in survivors of long-term Hodgkin lymphoma and may affect neurocognitive outcomes. Survivors (N = 204; 52.5% female; mean [standard deviation] age, 36.6 [8.01] years) treated thoracic age-, sex-, race/ethnicity-matched community controls 205; 51.7% 36.7 [9.17] completed standardized testing, echocardiography, pulmonary function tests, vascular studies during the same visit. Treatments were abstracted from...
Abstract Background Neurocognitive impairments are sequelae of childhood cancer treatment, however little guidance is given to clinicians on common phenotypes impairment or modifiable risk factors that could lead personalized interventions in survivorship. Methods Standardized clinical testing neurocognitive function was conducted 2958 (74.1%) eligible survivors, who were at least 5 years postdiagnosis and aged older than 18 years, 477 community controls. Impairment examined across 20...