A5057662519- Childhood Cancer Survivors' Quality of Life
- Frailty in Older Adults
- Acute Lymphoblastic Leukemia research
- Nutrition and Health in Aging
- Palliative Care and End-of-Life Issues
- Obesity, Physical Activity, Diet
- Renal and related cancers
- Family Support in Illness
- Health and Lifestyle Studies
- Nutritional Studies and Diet
- Eating Disorders and Behaviors
- Adolescent and Pediatric Healthcare
- Diet and metabolism studies
- Physical Activity and Health
- Cancer Risks and Factors
- Cancer survivorship and care
- School Health and Nursing Education
- Disaster Response and Management
- Resilience and Mental Health
- Body Composition Measurement Techniques
- Coffee research and impacts
- Renal cell carcinoma treatment
- DNA Repair Mechanisms
- Smoking Behavior and Cessation
- Obesity and Health Practices
St. Jude Children's Research Hospital
2016-2025
Juno Therapeutics (Germany)
2018
Pfizer (United Kingdom)
2018
Gilead Sciences (Germany)
2018
Medtronic (United States)
2018
Cytokinetics (United States)
2018
Incyte (United States)
2018
Alpine Immune Sciences (United States)
2018
Emory University
2009-2014
University of Pennsylvania
2009
BACKGROUND Childhood cancer survivors (CCS) are at an increased risk of developing metabolic syndrome (MetSyn), which may be reduced with lifestyle modifications. The purpose this investigation was to characterize habits and associations MetSyn among CCS. METHODS CCS who were ≥ 10 years from diagnosis, aged > 18 years, participating in the St. Jude Lifetime Cohort Study completed medical laboratory tests a food frequency questionnaire. Third Report National Cholesterol Education Program...
Purpose Childhood cancer survivors are at increased risk of subsequent neoplasms (SNs), but the germline genetic contribution is largely unknown. We assessed pathogenic/likely pathogenic (P/LP) mutations in predisposition genes to their SN risk. Patients and Methods Whole-genome sequencing (30-fold) was performed on samples from childhood who were ≥ 5 years since initial diagnosis participants St Jude Lifetime Cohort Study, a retrospective hospital-based study with prospective clinical...
We investigated the association between prevalence of symptoms and health-related quality life (HRQOL) in adult survivors childhood cancer enrolled St Jude Lifetime Cohort study.
Background The prevalence of low bone mineral density (BMD) in adult survivors childhood acute lymphoblastic leukemia (ALL), and the degree recovery or decline, are not well elucidated. Procedure Study subjects (age ≥ 18 years ≥10 post‐diagnosis) participated an institutional follow‐up protocol risk‐based clinical evaluation based on Children's Oncology Group guidelines. Trabecular volumetric BMD was ascertained using quantitative computed tomography, reported as age‐ sex‐specific Z‐scores....
Although premature aging is a significant concern in adult survivors of childhood cancer, little known about the role diet this vulnerable population. Therefore, we examined whether dietary patterns specific to cancer are associated with aging. This cross-sectional study included 2904 (mean age = 31 years, SD 8 years) St. Jude Lifetime Cohort. Diet was assessed using food frequency. Four were identified: (1) plant-based pattern high whole grains, fruit, and vegetables; (2) fast-food...
<h3>Objective</h3> To determine the efficacy of a 2-year obesity prevention program in African American girls. <h3>Design</h3> Memphis GEMS (Girls' health Enrichment Multi-site Studies) was controlled trial which girls were randomly assigned to an or alternative intervention. <h3>Setting</h3> Local community centers and YWCAs (Young Women's Christian Associations) Memphis, Tennessee. <h3>Participants</h3> Girls aged 8 10 years (N = 303) who identified by parent guardian as had body mass...
Abstract Background To evaluate long‐term health outcomes among childhood cancer survivors, St. Jude Children's Research Hospital (SJCRH) has established the Lifetime Cohort Study (SJLIFE), comprised of adult survivors who undergo risk‐directed clinical assessments. As in any human research study, SJLIFE participants are volunteers may not represent source population from which they were recruited. A lack proportional representation could result biased estimates exposure‐outcome...
Significance Statement Although associations of treatment for childhood cancer with acute kidney toxicity are well described, evidence informing late sequelae is less robust. The authors evaluated the prevalence and factors associated increased odds impairment in a large cohort adult survivors diagnosed ≥10 years earlier. About 2.1% had stages 3–5 CKD. Factors CKD included ever calcineurin inhibitor, increasing cumulative dose certain chemotherapy agents, volume irradiated to ≥5 or Gy,...
Background Survivors of childhood acute lymphoblastic leukemia (ALL) are at increased risk for both treatment‐related exercise intolerance and neurocognitive deficits. This analysis aimed to identify the association between impairments in ALL survivors. Methods Cardiopulmonary testing, results from a 2‐hour standardized neuropsychological assessment, self‐report questionnaires were obtained 341 adult survivors 288 controls. Multivariable modeling was used test associations oxygen uptake 85%...
Abstract Background The impact of specific treatment modalities on long‐term renal function and blood pressure among adult survivors Wilms tumor (WT) has not been well documented. Methods Among 40 WT 35 noncancer controls, we estimated the glomerular filtration rate (eGFR) using Chronic Kidney Disease‐Epidemiology (CKD‐EPI) equations with without cystatin C, obtained 24‐hour ambulatory readings, and, only, measured 99m Tc diethylenetriamine pentaacetic acid (DTPA) plasma clearance. Survivors...
Exercise interventions for survivors of childhood cancer (survivors) focus on improving cardiovascular fitness and muscle strength. We aimed to examine associations between personality traits change in physical function outcomes who completed a resistance training (RT) intervention. Participants were 5+ year the St. Jude Lifetime Cohort. Personality assessed using Big Five Inventory 2 (BFI-2). Grip strength was measured hand-held dynamometry. Quadriceps isokinetic Walking speed with...
Abstract BACKGROUND Survivors of childhood cancer report poor health‐related quality life (HRQOL). Modifiable lifestyle factors such as nutrition and physical activity represent opportunities for interventions to improve HRQOL. METHODS The authors examined the association between modifiable HRQOL among 2480 adult survivors in St. Jude Lifetime Cohort Study. Dietary intake, activity, cigarette smoking, alcohol consumption were assessed through questionnaires. Weight height measured clinic....
Abstract Background Some adult survivors of childhood cancers develop frailty at higher rates than expected based on their chronological age. This study examined the incidence among 10 or more years after diagnosis, prevalence 5 later, and risk factors for becoming frail. Methods Frailty was measured entry later. Logistic regression tested associations several with having all participants separately by sex status. Cox models evaluated hazard death associated considering covariates. Results...
To identify dietary factors that are related to premature aging in adult survivors of childhood cancer, we examined the associations between plant food intakes and age-related deficit accumulation.
To determine the frequency and characteristics of energy intake underreporting in African-American preadolescent girls as part Girls health Enrichment Multi-site Studies (GEMS).Energy was summarized using Nutrition Data System for Research software computed a 3-day average 24-h dietary recalls. Physical activity assessed by an accelerometer, basal metabolic rate (BMR) estimated World Health Organization's prediction equation, caloric based on Goldberg equation.Using conservative criterion...
There is limited understanding of associations between a combination health behaviors (physical activity, sedentary/screen-time, diet) and cardiometabolic risk factors, physical performance, emotional among young (<18) childhood cancer survivors (CCS). The aims this research were to address gap by 1) deriving behavior adherence profiles CCS, 2) examining demographic, diagnosis and/or treatment exposures, cardiometabolic, functioning with profile membership.
BACKGROUND Sedentary behaviors are associated with poor health outcomes in the general population, but their clinical impact on adult survivors of childhood acute lymphoblastic leukemia (ALL) has not been characterized to date. In current study, we described prevalence sedentary ALL and examined associations between time spent body composition onset cardiovascular disease (CVD) risk factors. METHODS Participants' self‐reported screen (eg, television, computer) activity as measured by...
The purpose of this investigation was to determine the efficacy two evidence-based tobacco quitlines in adult survivors childhood cancer who regularly smoke cigarettes.