A5013015739- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Glioma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cancer-related cognitive impairment studies
- Renal and related cancers
- Epigenetics and DNA Methylation
- Palliative Care and End-of-Life Issues
- Brain Metastases and Treatment
- Family Support in Illness
- Mitochondrial Function and Pathology
- Genomics and Rare Diseases
- Cancer survivorship and care
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Frailty in Older Adults
- Genetics and Neurodevelopmental Disorders
- Chronic Disease Management Strategies
- Health, Environment, Cognitive Aging
- Electron Spin Resonance Studies
- Diabetic Foot Ulcer Assessment and Management
- COVID-19 and healthcare impacts
- Cancer Genomics and Diagnostics
- Folate and B Vitamins Research
St. Jude Children's Research Hospital
2016-2025
Weatherford College
2024
Disco (Germany)
2024
Juno Therapeutics (Germany)
2018
Pfizer (United Kingdom)
2018
Gilead Sciences (Germany)
2018
Medtronic (United States)
2018
Cytokinetics (United States)
2018
Incyte (United States)
2018
Alpine Immune Sciences (United States)
2018
Frailty, a phenotype reported among 9.9% of individuals 65 years old and older (9.6% women; 5.2% men), has not been assessed adult childhood cancer survivors (CCS). We estimated the prevalence frailty examined associations with morbidity mortality.
Purpose Childhood cancer survivors are at increased risk of subsequent neoplasms (SNs), but the germline genetic contribution is largely unknown. We assessed pathogenic/likely pathogenic (P/LP) mutations in predisposition genes to their SN risk. Patients and Methods Whole-genome sequencing (30-fold) was performed on samples from childhood who were ≥ 5 years since initial diagnosis participants St Jude Lifetime Cohort Study, a retrospective hospital-based study with prospective clinical...
Associations between modifiable chronic health conditions (CHCs), social determinants of health, and late mortality (defined as death occurring ≥5 years after diagnosis) in childhood cancer survivors are unknown.To explore associations CHCs within the context health.This longitudinal cohort study used data from 9440 individuals who were eligible to participate St Jude Lifetime Cohort (SJLIFE), a retrospective with prospective clinical follow-up that was initiated 2007 characterize outcomes...
Significance Statement Although associations of treatment for childhood cancer with acute kidney toxicity are well described, evidence informing late sequelae is less robust. The authors evaluated the prevalence and factors associated increased odds impairment in a large cohort adult survivors diagnosed ≥10 years earlier. About 2.1% had stages 3–5 CKD. Factors CKD included ever calcineurin inhibitor, increasing cumulative dose certain chemotherapy agents, volume irradiated to ≥5 or Gy,...
PURPOSE To investigate cancer treatment plus pathogenic germline mutations (PGMs) in DNA repair genes (DRGs) for identification of childhood survivors at increased risk subsequent neoplasms (SNs). METHODS Whole-genome sequencing was performed on blood-derived from the St Jude Lifetime Cohort. PGMs were evaluated 127 6 major pathways. Cumulative doses chemotherapy and body region–specific radiotherapy (RT) abstracted medical records. Relative rates (RRs) 95% CIs SNs by mutation status...
To leverage baseline global longitudinal strain (GLS) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) to identify childhood cancer survivors with a normal left ventricular ejection fraction (LVEF) at highest risk of future treatment-related cardiomyopathy.
Importance Certain cancer therapies are risk factors for epigenetic age acceleration (EAA) among survivors of childhood cancer, and EAA is associated with chronic health conditions (CHCs). However, small numbers younger (aged <20 years) previously evaluated have limited the ability to calculate this group. Objective To evaluate change rate (EA) in compared older possible association early-onset obesity years), severity/burden CHCs, late mortality (>5 years from...
Abstract Childhood cancer survivorship studies generate comprehensive datasets comprising demographic, diagnosis, treatment, outcome, and genomic data from survivors. To broadly share this data, we created the St. Jude Survivorship Portal (https://survivorship.stjude.cloud), first portal for sharing, analyzing, visualizing pediatric data. More than 1,600 phenotypic variables 400 million genetic variants more 7,700 childhood survivors can be explored on free, open-access portal. Summary...
Rationale: The relationship between treatment-related impairment of pulmonary function in adult survivors childhood cancer and subsequent physical has not been studied.Objectives: In this prospective evaluation 606 cancer, we sought to determine the risk factors for, as well functional impact of, clinically ascertained impairment.Methods: We measured FEV1, FVC, total lung capacity (TLC), single-breath diffusing for carbon monoxide corrected hemoglobin (DlCOcorr), expressing results percent...
Abstract Background The impact of specific treatment modalities on long‐term renal function and blood pressure among adult survivors Wilms tumor (WT) has not been well documented. Methods Among 40 WT 35 noncancer controls, we estimated the glomerular filtration rate (eGFR) using Chronic Kidney Disease‐Epidemiology (CKD‐EPI) equations with without cystatin C, obtained 24‐hour ambulatory readings, and, only, measured 99m Tc diethylenetriamine pentaacetic acid (DTPA) plasma clearance. Survivors...
The prevalence of diastolic dysfunction has not been systematically evaluated in a large population survivors childhood cancer using established guidelines and standards.This study sought to assess the progression adult exposed cardiotoxic therapy.Comprehensive, longitudinal echocardiographic examinations ≥18 years age ≥10 from diagnosis SJLIFE (St. Jude Lifetime Cohort Study) were performed. Diastolic was defined based on 2016 American Society Echocardiography/European Association...
Background: Childhood cancer survivors experience accelerated aging, largely due to treatment toxicity. We investigated how aging biomarkers, which quantify and capture multifaceted mechanisms, differentially mediate treatment-related cardiotoxicity. Methods: Peripheral blood samples from in the St Jude Lifetime Cohort were profiled with EPIC BeadChip generate DNA methylation (DNAm) data, three established biomarkers subsequently derived: epigenetic age (EA, reflecting alterations),...
Abstract Background Some adult survivors of childhood cancers develop frailty at higher rates than expected based on their chronological age. This study examined the incidence among 10 or more years after diagnosis, prevalence 5 later, and risk factors for becoming frail. Methods Frailty was measured entry later. Logistic regression tested associations several with having all participants separately by sex status. Cox models evaluated hazard death associated considering covariates. Results...
Abstract Purpose: To identify genetic factors associated with risk of stroke among survivors childhood cancer treated cranial radiotherapy (CRT). Experimental Design: We analyzed whole-genome sequencing (36.8-fold) data 686 European ancestry [median (range), 40.4 (12.4–64.7) years old; 54% male] from the St. Jude Lifetime Cohort study CRT, whom 116 (17%) had clinically diagnosed stroke. Association analyses (single-variant and Burden/SKAT tests) were performed, adjusting for demographic...
Cancer-related worry (CRW; concerns related to cancer and its late effects) is prevalent among childhood survivors. Elevated CRW has been associated with self-reported suboptimal physical activity. The aim of this investigation was describe associations between objectively assessed activity in
Abstract Background Childhood cancer survivors are at high risk for morbidity and mortality poor patient-reported outcomes, typically health-related quality of life (HRQOL). However, associations between DNA methylation–based aging biomarkers HRQOL have not been evaluated. Methods methylation was generated with Infinium EPIC BeadChip on blood-derived (median age blood draw = 34.5 years, range 18.5-66.6 years), assessed survey (mean 32.3 18.4-64.5 years) from 2206 in the St Jude Lifetime...
We aimed to systematically evaluate telomere dynamics across a spectrum of pediatric cancers, search for underlying molecular mechanisms, and assess potential prognostic value.The fraction telomeric reads was determined from whole-genome sequencing data paired tumor normal samples 653 patients with 23 cancer types the Pediatric Cancer Genome Project. Telomere were characterized as ratio fractions between samples. Somatic mutations gathered, RNA 330 analyzed gene expression, Cox regression...
Adult survivors of childhood cancer are at increased risk cardiac late effects.
Abstract Background Adult survivors of unilateral, nonmetastatic, non‐syndromic Wilms tumor (WT) treated with whole abdomen radiation therapy (WART) are at risk for impaired kidney function. The impact bias and accuracy on estimated glomerular filtration rate (eGFR) among adult WT has not been well documented. Procedure We clinically evaluated male female creatinine cystatin C, calculated eGFR using the Chronic Kidney Disease—Epidemiology equations without measured 99m Tc diethylenetriamine...