A5076569564- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Acute Lymphoblastic Leukemia research
- Chemotherapy-induced cardiotoxicity and mitigation
- Nutrition and Health in Aging
- Family Support in Illness
- Cancer survivorship and care
- Frailty in Older Adults
- Cancer-related cognitive impairment studies
- Heart Failure Treatment and Management
- Palliative Care and End-of-Life Issues
- Glioma Diagnosis and Treatment
- Cerebral Palsy and Movement Disorders
- Neuroblastoma Research and Treatments
- Diet and metabolism studies
- Intensive Care Unit Cognitive Disorders
- Optimism, Hope, and Well-being
- Cardiovascular and exercise physiology
- Family and Disability Support Research
- Muscle metabolism and nutrition
- Infant Development and Preterm Care
- Growth Hormone and Insulin-like Growth Factors
- Coenzyme Q10 studies and effects
- Cancer Treatment and Pharmacology
- Physical Activity and Health
St. Jude Children's Research Hospital
2016-2025
University of Tennessee Health Science Center
2018
National Cancer Institute
2018
Stony Brook University
2018
PURPOSE Exercise intolerance, associated with heart failure and death in general populations, is not well studied survivors of childhood cancer. We examined prevalence exercise intolerance exposed or to cardiotoxic therapy, associations among organ system function, mortality. METHODS Participants consisted 1,041 people who had survived cancer ≥ 10 years (and did have exposure anthracyclines and/or chest-directed radiation) 285 control subjects. was defined as peak oxygen uptake < 85%...
Bone accrual during youth is critical to establish sufficient strength for lifelong skeletal health. Children with cancer may develop low bone mineral density (BMD) any time before or after diagnosis.To evaluate the ability of low-magnitude, high-frequency mechanical stimulation enhance BMD among childhood survivors.Double-blind randomized clinical trial conducted at St Jude Children's Research Hospital from June 1, 2010, January 22, 2013, using survivors, ages 7 17 years, who were...
Abstract Background Healthy lifestyle choices, including participation in regular physical activity, may improve health outcomes survivors of childhood cancer. We aimed to evaluate the efficacy a web‐delivered activity intervention among adolescent increase moderate vigorous (MVPA) and fitness neurocognitive health‐related quality life (HRQoL) over 24 weeks. Procedure This randomized controlled trial was conducted (aged ≥11 <15 years) treated at single institution. Participants were...
Purpose Beyond survival, achieving independence is a primary goal for adult survivors of pediatric CNS tumors. However, the prevalence and risk factors failure to achieve independence, assessed with multiple concurrent indicators, have not been examined. Patients Methods Functional social was in 306 (astrocytoma [n = 130], medulloblastoma 77], ependymoma 36], other 63]; median current age, 25.3 years [range, 18.9 53.1 years]; time since diagnosis, 16.8 10.6 41.8 years]). Six observed...
Abstract Skeletal muscle (muscle) is essential for physical health and metabolic integrity, with sarcopenia (progressive mass loss weakness), a precursor of aging chronic disease. Loss lean quality (force generation per unit muscle) in the general population are associated fatigue, weakness, slowed walking speed, eventually interfering ability to maintain independence, impacting participation social roles life. Muscle strength impairments also documented during childhood cancer treatment,...
Eight percent of young-adult childhood cancer survivors meet criteria for frailty, an aging phenotype associated with poor health. In the elderly general population, frailty is neurocognitive decline; this association has not been examined in adult cancer.Childhood 18-45 years old (≥ 10 from diagnosis) were clinically evaluated prefrailty or (respectively defined as ≥ 2 3 of: muscle wasting, weakness, low energy expenditure, slow walking speed, and exhaustion [Fried criteria]) completed...
Purpose To compare peripheral nervous system function and balance between adult survivors of childhood acute lymphoblastic leukemia (ALL) matched controls to determine associations neuropathy (PN) limitations in static balance, mobility, walking endurance, quality life (QoL) among survivors. Patients Methods Three hundred sixty-five ALL 365 with no cancer history completed assessments PN (modified Total Neuropathy Score [mTNS]), (Sensory Organization Test [SOT]), mobility (Timed Up Go),...
Background Survivors of childhood acute lymphoblastic leukemia (ALL) are at increased risk for both treatment‐related exercise intolerance and neurocognitive deficits. This analysis aimed to identify the association between impairments in ALL survivors. Methods Cardiopulmonary testing, results from a 2‐hour standardized neuropsychological assessment, self‐report questionnaires were obtained 341 adult survivors 288 controls. Multivariable modeling was used test associations oxygen uptake 85%...
Cardiovascular disease is up to 10 times more likely among childhood cancer survivors compared siblings. Low cardiorespiratory fitness a modifiable risk‐factor for cardiovascular diseases. Yet, not routinely screened in pediatric oncology, and healthy VO 2max cut‐points are unavailable. We aimed predict by developing simple algorithm establish identifying survivors’ health‐risk zones. recruited 262 (8–18 years old, ≥1‐year posttreatment). Participants completed gold‐standard assessment...
Background Survivors of childhood cancer exposed to cardiotoxic therapies are at significant cardiovascular risk. The utility cardiac biomarkers for identifying the risk future cardiomyopathy and mortality is unknown. Methods N‐terminal pro–B‐type natriuretic peptide (NT‐proBNP) troponin T (cTnT) were assessed in 1213 adults 10 or more years from a diagnosis; 786 anthracycline chemotherapy and/or chest‐directed radiation therapy (RT). NT‐proBNP values above age‐ sex‐specific 97.5th...
Cancer survivors develop cancer and treatment-related morbidities at younger than normal ages are risk for early mortality, suggestive of an aging phenotype. The Cumulative Illness Rating Scale Geriatrics (CIRS-G) is specifically designed to describe the accumulation comorbidities over time with estimates severity such as total score (TS) which a sum possible conditions weighted by severity. These scores can then be used predict future mortality.
Exercise interventions for survivors of childhood cancer (survivors) focus on improving cardiovascular fitness and muscle strength. We aimed to examine associations between personality traits change in physical function outcomes who completed a resistance training (RT) intervention. Participants were 5+ year the St. Jude Lifetime Cohort. Personality assessed using Big Five Inventory 2 (BFI-2). Grip strength was measured hand-held dynamometry. Quadriceps isokinetic Walking speed with...
Abstract Background Some adult survivors of childhood cancers develop frailty at higher rates than expected based on their chronological age. This study examined the incidence among 10 or more years after diagnosis, prevalence 5 later, and risk factors for becoming frail. Methods Frailty was measured entry later. Logistic regression tested associations several with having all participants separately by sex status. Cox models evaluated hazard death associated considering covariates. Results...
There is limited understanding of associations between a combination health behaviors (physical activity, sedentary/screen-time, diet) and cardiometabolic risk factors, physical performance, emotional among young (<18) childhood cancer survivors (CCS). The aims this research were to address gap by 1) deriving behavior adherence profiles CCS, 2) examining demographic, diagnosis and/or treatment exposures, cardiometabolic, functioning with profile membership.
BACKGROUND Sedentary behaviors are associated with poor health outcomes in the general population, but their clinical impact on adult survivors of childhood acute lymphoblastic leukemia (ALL) has not been characterized to date. In current study, we described prevalence sedentary ALL and examined associations between time spent body composition onset cardiovascular disease (CVD) risk factors. METHODS Participants' self‐reported screen (eg, television, computer) activity as measured by...
Exercise intolerance is associated with increased risk for morbidity and mortality in childhood cancer survivors. However, an association between exercise psychosocial outcomes has not been fully explored.
Cancer-related worry (CRW; concerns related to cancer and its late effects) is prevalent among childhood survivors. Elevated CRW has been associated with self-reported suboptimal physical activity. The aim of this investigation was describe associations between objectively assessed activity in
Survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for low lean muscle mass and weakness, which may contribute to inactivity early development chronic diseases typically seen in older adults. Although increasing protein intake, combination with resistance training, improves other populations, it is not known whether muscular tissue among survivors ALL, whose impairments treatment-related, will respond similarly.The aim this study was evaluate associations dietary ALL age-,...
Muscle weakness, low lean body mass, and poor physical performance are prevalent among adult survivors of childhood cancer (survivors). We evaluated the feasibility effects resistance training with without protein supplementation on mass muscle strength survivors.This double-blind placebo-controlled trial enrolled ≥18 to <45 yr old. Participants were randomized supplement (21 g whey per day, 90 kcal) (RT + S) or placebo (sucrose, P). received educational materials, access a local fitness...
Abstract Background Cardiac autonomic dysfunction (CAD) is possible following treatment for childhood cancer. The aims of our analyses were to compare the prevalence CAD between adult survivors acute lymphoblastic leukemia and controls, exercise response among with without CAD, identify treatment‐related risk factors CAD. Procedure Participants treated at St. Jude Children's Research Hospital 1980 2003 ( N = 338). A comparison group matched race/ethnicity, age, sex was also recruited 325)....
Abstract Introduction We aimed to determine the prevalence of self‐reported adverse health status among childhood acute lymphoblastic leukemia (ALL) survivors and identify associations between components physical fitness status. Methods Participants included 365 ALL (mean age at evaluation 28.6 ± 5.9 years) age‐, sex‐, race‐matched community controls. Self‐report poor general health, mental functional impairments, activity limitations were used describe Fitness was evaluated by assessing...