A5022723817- History and Politics in Latin America
- Growth Hormone and Insulin-like Growth Factors
- Historical Studies in Latin America
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Childhood Cancer Survivors' Quality of Life
- Pancreatic function and diabetes
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Pregnancy and preeclampsia studies
- Historical Studies on Spain
- Adipose Tissue and Metabolism
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Latin American history and culture
- Colonialism, slavery, and trade
- Healthcare Systems and Practices
- Diet and metabolism studies
- Sephardic Jews and Inquisition Studies
- Acute Lymphoblastic Leukemia research
- Cuban History and Society
- Lipid metabolism and disorders
- Hormonal Regulation and Hypertension
- Glycogen Storage Diseases and Myoclonus
University of Colorado System
1984-2020
University of Colorado Boulder
1984-2020
University of Memphis
2015-2018
Sandia National Laboratories California
2017
University of Tennessee Health Science Center
2008-2016
Cincinnati Children's Hospital Medical Center
2014
Centre de Recherche et de Documentation sur les Amériques
2014
Centre National de la Recherche Scientifique
2014
Université Sorbonne Nouvelle
2014
Le Bonheur Children's Hospital
2008-2014
Protégé was a phase 3, randomized, double-blind, parallel, placebo-controlled 2-year study of three intravenous teplizumab dosing regimens, administered daily for 14 days at baseline and again after 26 weeks, in new-onset type 1 diabetes. We sought to determine efficacy safety immunotherapy 2 years identify characteristics associated with therapeutic response. Of 516 randomized patients, 513 were treated, 462 completed follow-up. Teplizumab (14-day full-dose) reduced the loss C-peptide mean...
OBJECTIVE The study seeks to improve access for underserved patients via novel integration of Pedi-Flite (a critical care transport team) and validate whether this safely enhances diabetes effectively expands the endocrine workforce. RESEARCH DESIGN AND METHODS retrospectively analyzed pager service use in a cohort established diabetic (n = 979) after inception support. Outcomes included incidence severity recurrent ketoacidosis (DKA) cost savings generated from reduced referrals emergency...
Bone accrual during youth is critical to establish sufficient strength for lifelong skeletal health. Children with cancer may develop low bone mineral density (BMD) any time before or after diagnosis.To evaluate the ability of low-magnitude, high-frequency mechanical stimulation enhance BMD among childhood survivors.Double-blind randomized clinical trial conducted at St Jude Children's Research Hospital from June 1, 2010, January 22, 2013, using survivors, ages 7 17 years, who were...
Mutations in the high-affinity sulfonylurea receptor (SUR)-1 cause one of severe recessively inherited diffuse forms congenital hyperinsulinism or, when associated with loss heterozygosity, focal adenomatosis. We hypothesized that SUR1 mutations would render beta-cell insensitive to sulfonylureas and glucose. Stimulated insulin responses were compared among eight patients (two mutations), six carrier parents, ten normal adults. In hyperinsulinism, acute response intravenous tolbutamide was...
Emerging data suggest that vitamin D status during childhood and adolescence can affect neurocognitive development. The purpose of this study was to investigate whether gestational 25(OH)D is associated with early cognitive receptive language Conditions Affecting Neurocognitive Development Learning in Early Childhood Study (CANDLE) enrolled 1503 mother-child dyads the second trimester healthy singleton pregnancies from Shelby County TN. Among 1020 participants total CANDLE cohort for whom...
To determine whether Compound 49b, a novel PKA-activating drug, can prevent diabetic-like changes in the rat retina through increased insulin-like growth factor binding protein-3 (IGFBP-3) levels.For cell culture studies, we used both human retinal endothelial cells (REC) and Müller either 5 mM (normal) or 25 (high) glucose. Cells were treated with 50 nM 49b alone of following treatment protein kinase A (PKA) siRNA IGFBP-3 siRNA. Western blotting ELISA analyses done to verify PKA knockdown,...
Mutations of glutamate dehydrogenase cause the hyperinsulinism/hyperammonemia syndrome by desensitizing to allosteric inhibition GTP. Normal activation leucine is thus uninhibited, leading us propose that children with will have exaggerated acute insulin responses in postabsorptive state. As hyperglycemia increases β-cell GTP, we also postulated high glucose concentrations would extinguish abnormal responsiveness patients. After an overnight fast, seven patients (aged 9 months 29 yr) had...
Congenital hyperinsulinism induces severe and unremitting hypoglycemia in newborns infants. If poorly controlled, seizures irreversible brain damage may result. Subtotal (<95%) or near-total (95% to 98%) pancreatectomy have been performed for glycemic control babies who do not respond aggressive medical therapy. Because often persists after subtotal resection, 95% has emerged as the procedure of choice. To define effect more less extensive on management outcome refractory congenital...
Abstract Our study was designed to characterize the patterns of growth, in medium term, children with functionally univentricular hearts managed a hemi-Fontan procedure infancy, followed by modified Fontan operation early childhood. Failure growth is common patients congenital cardiac malformations, and may be related congestive heart failure hypoxia. Repair simple lesions appears reverse retardation growth. Palliation single ventricular physiology staged reduces adverse effects hypoxemia...
Abstract Background We sought to improve lumbar spine bone mineral density (LS‐BMD) in long‐term survivors of childhood acute lymphoblastic leukemia (ALL) using calcium and cholecalciferol supplementation. Procedure This double‐blind, placebo‐controlled trial randomized 275 participants (median age, 17 [9–36.1] years) with age‐ gender‐specific LS‐BMD Z‐scores <0 receive nutritional counseling supplementation 1,000 mg/day 800 International Unit or placebo for 2 years. The primary outcome...
General and diabetes-specific family functioning may be associated with youth’s adaptation to type 1 diabetes (T1D); however, empirically derived patterns of conflict among youth have not been explored in relation T1D adaptation.Youth (N = 161, aged 12–18) caregivers completed measures that served as indicators latent profile analyses. Differences glycemic control (measured by hemoglobin A1cs [HbA1c] health-related quality life [HRQoL]) were compared across profiles.Four profiles varied...
Angiogenic factors, such as vascular endothelial-derived growth factor (VEGF) and IGF-I, play pivotal roles in endothelial proliferation migration. IGF binding protein-3 (IGFBP-3) is emerging a key regulator of cell apoptosis, both an antagonist independent molecule. We investigated the role IGFBP-3 VEGFmediated survival human macrovascular umbilical vein cells (HUVEC). Specific commercial ELISAs quantified Akt phosphorylation was assessed by immunoblots confocal microscopy. IGF-I VEGF...
Psychological flexibility, a complex concept encompassing both acceptance and action related factors, has been identified as target for intervention diabetes management. Research suggests acceptance, self-management, stress, all factors that influence psychological have an impact on adaptation to type 1 (T1D) by youth independently. However, yet be explored is individually varying patterns of these variables how they may relate outcomes. The present study aimed establish individual...
Transient hyperglycemia occurs commonly during the treatment for childhood acute lymphoblastic leukemia (ALL). The purpose of this study was to examine incidence and risk factors transient induction chemotherapy in Hispanic pediatric patients diagnosed with B-Precursor ALL.The cohort consisted 155 ALL treated at one two South Texas oncology centers between 1993 2002. Hyperglycemia defined as > or = 2 glucose determinations 200 mg/dl first 28 days chemotherapy.Overall, 11.0% developed...
The growth hormone (GH)-dependent factors insulin-like factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) may be superior to provocative GH testing in diagnosing deficiency (GHD) children. In adults with brain tumours (BT) GHD, however, more accurately reflects GHD than either IGF-I or IGFBP-3. We assessed factor levels children due BT respect tumour type, pubertal stage, velocity, bone age delay, body mass index (BMI).Retrospective case review of all patients followed at our centre...