A5025699758- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Nausea and vomiting management
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Pediatric Pain Management Techniques
- Cancer Genomics and Diagnostics
- Cancer therapeutics and mechanisms
- Palliative Care and End-of-Life Issues
- Lung Cancer Research Studies
- Cancer Risks and Factors
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Bone Tumor Diagnosis and Treatments
- Glioma Diagnosis and Treatment
- Family Support in Illness
- Lung Cancer Treatments and Mutations
- Neurofibromatosis and Schwannoma Cases
- Chemotherapy-related skin toxicity
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Methemoglobinemia and Tumor Lysis Syndrome
- Hemoglobinopathies and Related Disorders
- Neuroendocrine Tumor Research Advances
- Chronic Myeloid Leukemia Treatments
The University of Texas Health Science Center at San Antonio
2007-2023
Mays Cancer Center at UT Health San Antonio
2023
The University of Texas Health Science Center at Houston
2020-2022
Hospital for Sick Children
2021
Montreal Children's Hospital
2021
McGill University
2021
Children's Hospital of Eastern Ontario
2021
University of Toronto
2021
3M (United States)
2021
SickKids Foundation
2021
The use of radiographic response as the primary end point in phase II osteosarcoma trials may limit optimal detection treatment because calcified tumor matrix. We performed this study to determine if time progression could be used an for subsequent studies.We a retrospective analysis outcome patients with recurrent/refractory enrolled one seven conducted by Children's Oncology Group and predecessor groups from 1997 2007. All RECIST or WHO criteria rate. following potential prognostic...
Abstract Background Early recognition and aggressive treatment of hemophagocytic lymphohistiocytosis (HLH) has changed a uniformly fatal disease to one 55% survive. We examined the diagnosis pediatric patients with HLH from three largest academic medical centers in Texas for information on modern non‐study survival. In contrast previously reported series, racial ethnic composition provided unique opportunity evaluate impact race ethnicity survival HLH. Procedure A retrospective chart review...
The MAPK pathway is an emerging target across a number of adult and pediatric tumors. Targeting the downstream effector MAPK, MEK1, proposed strategy to control growth MAPK-dependent iMATRIX-cobi assessed safety, pharmacokinetics, anti-tumor activity cobimetinib, highly selective MEK inhibitor, in children young adults with relapsed/refractory solid This multicenter Phase I/II study enrolled patients aged 6 months < 30 years tumors known/expected involvement. Patients received cobimetinib...
Cancers cause significant mortality and morbidity in adolescents young adults (AYAs), but their biological underpinnings are incompletely understood. Here, we analyze clinical genomic disparities between AYAs older (OAs) more than 100,000 cancer patients. We find differences presentation OAs, including sex, metastasis rates, race ethnicity, histology. In most types, AYA tumors show lower mutation burden less genome instability. Accordingly, genes mutations copy number changes AYAs, the...
Transient hyperglycemia occurs commonly during the treatment for childhood acute lymphoblastic leukemia (ALL). The purpose of this study was to examine incidence and risk factors transient induction chemotherapy in Hispanic pediatric patients diagnosed with B-Precursor ALL.The cohort consisted 155 ALL treated at one two South Texas oncology centers between 1993 2002. Hyperglycemia defined as > or = 2 glucose determinations 200 mg/dl first 28 days chemotherapy.Overall, 11.0% developed...
BACKGROUND Chemotherapy‐induced nausea and vomiting remain common, distressing side effects of chemotherapy. It has been reported that acupressure prevents chemotherapy‐induced in adults, but it not well studied children. METHODS In this multicenter, prospective, randomized, single‐blind, sham‐controlled trial, the authors compared acute‐phase severity patients ages 4 to 18 years who were receiving highly emetic chemotherapy using standard antiemetic agents combined with wrist bands, most...
Background The Children's Oncology Group (COG) has endorsed a clinical practice guideline (CPG) for acute chemotherapy-induced nausea and vomiting (CINV) prophylaxis in children with cancer. This project aims to describe current CINV at COG sites the gap between this CPG recommendations. Procedure Two surveys were developed. first survey, sent 94 cancer control supportive care responsible individuals (CCL RIs) institutions, asked if institution had standardized approach focused on antiemetic...
Abstract Background Little is known regarding risk factors for chemotherapy‐induced nausea (CIN) in pediatric patients. Procedure A secondary analysis was conducted of a previously published multicenter, prospective, randomized, single‐blind, sham‐controlled trial assessing the efficacy acupressure preventing CIN patients receiving highly emetogenic chemotherapy. The primary outcome severity, self‐reported using Pediatric Nausea Assessment Tool. relationships between acute and delayed...
Abstract Subcutaneous patient-derived xenografts (PDXs) are an important tool for childhood cancer research. Here, we describe a resource of 68 early passage PDXs established from 65 pediatric solid tumor patients. Through genomic profiling paired and patient tumors (PTs), observe low mutational similarity in about 30% the PT/PDX pairs. Clonal analysis these pairs show aggressive PT minor subclone seeds major clone PDX. We evidence that this is more immunogenic likely suppressed by immune...
Abstract BACKGROUND The objective of this study was to examine changes over time in body mass index (BMI) from diagnosis through chemotherapy for pediatric patients with B‐precursor acute lymphoblastic leukemia (ALL). METHODS cohort consisted 141 white Hispanic who were diagnosed ALL and treated at 2 South Texas oncology centers between 1993 2002. Changes age‐standardized gender‐standardized BMI scores assessed. RESULTS exhibited a steady increase age‐adjusted gender‐adjusted the first 12...
Rebeccamycin Analogue (NSC #655649), a chemically synthesized glycosyl-dichloro-indolocarbazole derivative of rebeccamycin with topoisomerase inhibiting activity, has in vitro activity against pediatric tumor cell lines and specimens including rhabdomyosarcoma, neuroblastoma, Ewing's sarcoma medulloblastoma.The primary objective this trial was to determine the response rate analogue NSC #655649 children refractory solid CNS tumors. Secondary objectives included further evaluation toxicity...
Abstract Introduction While it is known that leukemia therapy associated with obesity in survivorship, limited information available on its time‐related pattern of development and variation across patient subgroups. The goal the present study was to examine demographic correlates body mass index (BMI) changes over time from diagnosis through chemotherapy for children B‐precursor acute lymphoblastic (ALL). Methods cohort consisted 307 pediatric patients diagnosed ALL who were treated at four...
Osteosarcoma is the most common bone malignancy in children, adolescents, and young adults. Most study cohorts have 10% to 15% Hispanic patients that encompass many different backgrounds. This characterizes effect of mainly Mexican American ethnicity on outcome adults with osteosarcoma.A retrospective analysis demographics, tumor characteristics, response treatment, survival all localized osteosarcoma extremity below 30 years age was performed. A Kaplan-Meier estimates log-rank tests Cox...
Few studies have explored interventions to improve adolescent and young adult (AYA) cancer care delivery. While many AYAs receive at NCI Community Oncology Research Program (NCORP) sites, few enroll on clinical trials. Barriers facilitators pediatric oncologist activation of enrollment an AYA cross-network National Clinical Trials Network (NCTN) supportive trial were assessed using a survey that was administered 162 stakeholders representing all 47 children's oncology group (COG)...
Background Parents of adolescents and young adults (AYAs) with cancer offer primary support to their children often experience own high levels distress, affecting parent-AYA communication quality life. Objective To reduce parent distress improve during high-risk treatment, we examined efficacy a self-care intervention for parents indirect benefit AYAs receiving therapeutic music video (TMV) intervention. Methods In this study, conducted multisite, randomized controlled trial enrolled as...
Anemia and hepatosplenomegaly are common reasons for referring a child to pediatric hematologist or oncologist. Among the many causes these findings is severe rickets, which has been shown be associated with secondary myelofibrosis myeloid metaplasia. The authors present case of an infant rickets review differential diagnosis from viewpoint hematologist/oncologist.
Abstract BACKGROUND The objective of the current study was to compare chemotherapy dose modifications in obese (a body mass index [BMI] > 95%) and nonobese BMI ≤ pediatric patients with acute lymphoblastic leukemia (ALL). METHODS cohort comprised 199 diagnosed ALL who were treated at 1 2 South Texas oncology centers between 1990–2000. relative modification during induction phase calculated as ratio 1) actual administered L‐asparaginase 2) protocol‐calculated L‐asparaginase. extent which...
Objectives Symptom screening is important to achieving symptom control. Screening in Paediatrics Tool (SSPedi) validated for English-speaking children. were translate SSPedi into Spanish, and evaluate the understandability cultural relevance of translated version among Spanish-speaking children with cancer paediatric haematopoietic stem cell transplant recipients. Methods We conducted a multiphase, descriptive study Spanish. The first step was determine whether one Spanish would be...
10042 Background: The use of radiographic response as the primary endpoint in phase II osteosarcoma (OS) trials may limit optimal detection treatment due to calcified tumor matrix. We assessed outcome data for children with recurrent/refractory OS enrolled on single agent Children’s Oncology Group trial establish this cohort’s baseline expected survival outcome. Methods: performed a retrospective analysis one seven an stratum conducted by COG and predecessor groups from 1997-2007. Trials...
Objectives To translate a symptom screening tool developed for paediatric patients receiving cancer therapies called Symptom Screening in Pediatrics Tool (SSPedi) into Argentinian Spanish and to evaluate the understandability cultural relevance of translated version SSPedi among children with haematopoietic stem cell transplant (HSCT) recipients. Methods We conducted multiphase, descriptive study Spanish. Using two translators, forward backward translations were performed. The was evaluated...
Abstract Introduction: Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. Among various subtypes, alveolar RMS (ARMS) generally more aggressive and usually carries fusion transcription factor, PAX3/7-FKHR. High-risk ARMS has an extremely poor prognosis, with ~25% five-year survival. Hence, novel therapeutic approaches are urgently needed. However, potential therapies often hindered by immunosuppressive tumor microenvironment (TME) associated sarcomas. The TME highly...
Abstract Purpose We performed a Phase I trial of irofulven (MGI 114) to determine the maximum tolerated dose (MTD), dose‐limiting toxicity (DLT), and plasma pharmacokinetics in children ≤21 years age with refractory/recurrent malignancies. Experimental Design Thirty‐five patients were entered into study, whom 34 eligible. Patients received Irofulven daily × 5 days every 28 over 10 min, following pre‐treatment ondansetron (0.45 mg/kg) dexamethasone (12 mg/m 2 ). The initial was 8 daily,...
Chemotherapy-induced nausea and vomiting (CINV) continue to negatively influence the quality of life both adult pediatric cancer patients (Dupuis et al., 2010; Farrell 2013; Russo 2014; Hinds 2009; Sommariva 2016). Vomiting retching are symptoms that can be assessed objectively while nausea, a subjective symptom, is more difficult quantify. Adult usually describe severity they feel using self-report visual analog or adjectival rating scales. Instruments such as Multinational Association...