A5024810268- Geriatric Care and Nursing Homes
- Meta-analysis and systematic reviews
- Dementia and Cognitive Impairment Research
- Treatment of Major Depression
- Cardiac, Anesthesia and Surgical Outcomes
- Statistical Methods in Clinical Trials
- Musculoskeletal pain and rehabilitation
- Hip and Femur Fractures
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Mental Health Treatment and Access
- Pneumonia and Respiratory Infections
- Health and Wellbeing Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Diabetes Management and Education
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Patient Satisfaction in Healthcare
- Frailty in Older Adults
- Ferroptosis and cancer prognosis
- TGF-β signaling in diseases
- Lipoproteins and Cardiovascular Health
- Nutritional Studies and Diet
The University of Texas at San Antonio
2002-2025
Academy of Medicine
2023
The University of Texas Health Science Center at San Antonio
2010-2020
The University of Texas Health Science Center at Houston
1994-2020
University of Texas Health Science Center at Dallas
2020
University Hospitals Birmingham NHS Foundation Trust
2018
University of Pennsylvania
2017
American College of Physicians
2015-2017
Urology San Antonio
2016
Johns Hopkins University
2015
This study details the psychometric evaluation of Quality Life Inventory (QOLI), a measure life satisfaction that may complement symptom-oriented measures psychological functioning in evaluating outcome interventions aimed at ameliorating mental disorders, disabling physical illnesses, and community-wide social problems
ContextInsufficient evidence exists for recommendation of specific effective treatments older primary care patients with minor depression or dysthymia.ObjectiveTo compare the effectiveness pharmacotherapy and psychotherapy in settings among persons dysthymia.DesignRandomized, placebo-controlled trial (November 1995–August 1998).SettingFour geographically clinically diverse practices.ParticipantsA total 415 (mean age, 71 years) (n = 204) dysthymia 211) a Hamilton Depression Rating Scale...
A primary goal of meta-analysis is to improve the estimation treatment effects by pooling results similar studies. This article explains how most widely used method for heterogeneous studies--the Der Simonian-Laird (DL) estimator--can produce biased estimates with falsely high precision. classic example presented show that use DL estimator can lead erroneous conclusions. Particular problems are discussed, and several alternative methods summarizing evidence presented. The authors support...
<h3>Background.</h3> —Past studies suggest multidisciplinary interventions that include physical therapy (PT) can improve function of nursing home residents. This trial specifically evaluates effects PT for frail long-stay <h3>Design.</h3> —Randomized, controlled trial. <h3>Setting.</h3> —One academic and eight community homes. <h3>Patients.</h3> —A total 194 elderly residents dependent in at least two activities daily living residing the 3 months. <h3>Interventions.</h3> —Patients were...
How higher organisms respond to elevated oxidative stress in vivo is poorly understood. Therefore, we measured parameters and gene expression alterations (Affymetrix arrays) the liver caused by reactive oxygen species induced diquat or genetic ablation of major antioxidant enzymes CuZn-superoxide dismutase ( Sod1) glutathione peroxidase-1 Gpx1). Diquat (50 mg/kg) treatment resulted a significant increase damage within 3–6 h wild-type mice without any lethality. In contrast, Sod1 −/− Gpx1...
The benefits and indications for blood transfusion are controversial. One possible reason to transfuse is improve functional recovery after major surgery. However, the data linking improved function with higher Hb concentration limited.A: retrospective cohort study was performed in 5793 patients at least 60 years old undergoing hip fracture repair 20 academic community hospitals. primary outcome distance walked time of discharge from hospital. mean postoperative main exposure variable...
Rationale: One of the limitations associated with lung transplantation is lack available organs.Objective: To determine whether a donor–management protocol could increase number lungs for without affecting survival rates recipients.Methods: We implemented San Antonio Lung Transplant managing potential donors according to modifications standard criteria donor selection and strategies management. then compared information gathered during 4-yr period, which was used period before...
Abstract Transforming growth factor-β (TGF-β) signaling has been shown to promote invasion and metastasis in various models of human cancers. In this study, we investigated the efficacy a TGF-β type I receptor kinase inhibitor (TβRI-I) limit early systemic metastases an orthotopic xenograft model lung intracardiac injection experimental bone using breast carcinoma MDA-MB-435-F-L cells, highly metastatic variant cancer MDA-MB-435 expressing enhanced green fluorescent protein (EGFP). Treatment...
Background. Studies suggest that statins and angiotensin-converting enzyme (ACE) inhibitors might be beneficial for the treatment of infections. Our purpose was to examine association statin, ACE inhibitor, angiotensin II receptor blocker (ARB) use with pneumonia-related outcomes. Methods. We conducted a retrospective cohort study using Department Veterans Affairs data patients aged ≥65 years hospitalized pneumonia. performed propensity-score matching 3 medication classes simultaneously....
Fenofibrate is a peroxisome proliferator-activated receptor alpha agonist widely used in clinical practice, but its mechanism of action incompletely understood.The aim the study was to assess whether improvement subclinical inflammation or glucose metabolism contributes antiatherogenic effects insulin-resistant subjects with metabolic syndrome (MetS).We conducted randomized, double-blind, placebo-controlled research unit at an academic center.We studied 25 nondiabetic MetS subjects.We...
OBJECTIVE: To compare case‐finding tools for depression in the nursing home setting and to evaluate effects of subject function, cognition, disease number on test performance. DESIGN : Cross‐sectional survey. SETTING One academic four community homes. SUBJECTS hundred thirty‐four randomly selected, mildly cognitively impaired, functionally dependent residents. METHODS AND MEASURES The Geriatric Depression Scale (GDS), Short (SGDS), Center Epidemiologic Studies (CES‐D), Brief Carrol Rating...
Despite the development of several models care delivery for patients with chronic illness, consistent improvements in outcomes have not been achieved. These inconsistent results may be less related to content themselves, but their underlying conceptualization clinical settings as linear, predictable systems. The science complex adaptive systems (CAS), suggests that are non-linear, and increasingly has used a framework describing understanding purpose this study is broaden by examining...
Recent studies suggest that statins and angiotensin-converting enzyme (ACE) inhibitors may have beneficial effects for some types of infections. The present study aimed to examine the association outpatient use these medications on 30-day mortality subjects aged >65 yrs hospitalised with community-acquired pneumonia. A retrospective national cohort was conducted using Department Veterans Affairs administrative data including ≥65 pneumonia, having ≥1 yr prior care. In total, 8,652 were...
Our purpose in this article is to describe and illustrate the application of cluster analysis identify clinically relevant multimorbidity groups. Multimorbidity co-occurrence 2 or more illnesses within a single person, which raises question whether consistent, useful groups exist among sets chronic illnesses. Application involves sequence critical methodological analytic decisions that influence quality meaning clusters produced. We set 45 primary care patients (N = 1,327,328), with...