A5048634068- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Neonatal Health and Biochemistry
- Bone and Joint Diseases
- Prenatal Screening and Diagnostics
- Erythrocyte Function and Pathophysiology
- Sexual function and dysfunction studies
- Genital Health and Disease
- Hematopoietic Stem Cell Transplantation
- Pharmacological Effects and Toxicity Studies
- Parvovirus B19 Infection Studies
- Childhood Cancer Survivors' Quality of Life
- Folate and B Vitamins Research
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood disorders and treatments
- Adolescent and Pediatric Healthcare
- Pneumocystis jirovecii pneumonia detection and treatment
- Metabolism and Genetic Disorders
- Pneumonia and Respiratory Infections
- Reproductive Health and Contraception
- Autoimmune and Inflammatory Disorders Research
- Restraint-Related Deaths
- Child Abuse and Related Trauma
The University of Texas Southwestern Medical Center
2015-2024
Children's Medical Center
2004-2024
Center for Cancer and Blood Disorders
1998-2024
Southwestern Medical Center
2004-2022
University of Florida
2016
Columbus Oncology and Hematology Associates
2016
Pediatrics and Genetics
1999-2013
St. Jude Children's Research Hospital
1997-2005
Southwestern University
2005
Medical College of Wisconsin
2005
Sickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has profound multiorgan effects. The low prevalence SCD ( approximately 100,000/US) limited progress in clinical, basic, and translational research. Lack large, readily accessible population for clinical studies contributed to the absence standard definitions diagnostic criteria numerous complications inadequate understanding pathophysiology. In 2005, Comprehensive Cell Centers initiated project establish...
PURPOSE: To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine (AZA), evaluate their clinical management. PATIENTS AND METHODS: TPMT metabolism assessed all referred between 1994 1999 for evaluation of excessive toxicity while receiving MP AZA. activity was measured by radiochemical analysis, determined mutation-specific polymerase chain reaction restriction fragment length polymorphism...
A multicenter investigation of allogeneic bone marrow transplantation for children with sickle cell disease was conducted that included 27 European and North American transplant centers. Fifty-nine patients who ranged in age from 3.3 to 15.9 years (median, 10.1 years) received HLA-identical sibling allografts between September 1991 April 2000. Fifty-five survive, 50 survive free disease, a median follow-up 42.2 months (range, 11.8 115 months) after transplantation. Of the successful...
We conducted a prospective, multicenter investigation of human-leukocyte antigen (HLA) identical sibling bone marrow transplantation (BMT) in children with severe sickle cell disease (SCD) between 1991 and 2000. To determine if were protected from complications SCD after successful BMT, we extended our initial study BMT for to conduct assessments the central nervous system (CNS) pulmonary function 2 or more years transplantation. In addition, impact on gonadal was studied. After patients...
Pediatric health-related quality of life (HRQOL) questionnaires have been validated in children with sickle cell disease (SCD), but small sample sizes these studies limited clinical comparisons. We used the baseline data from Collaborative Data (C-Data) Project Comprehensive Sickle Cell Centers (CSCC) Clinical Trial Consortium to perform a detailed, descriptive study HRQOL using PedsQL version 4.0 generic core and fatigue scales.Retrospective were obtained via medical record abstraction....
Adults with Sickle Cell Disease (SCD) experience multiple disease-related complications, but few studies have examined relationships between these events and health-related quality of life (HRQOL). We determined the number type previous or co-occurring SCD-related complications their reported HRQOL in a cohort 1,046 adults from Comprehensive Centers (CSCC). Participants had median age 28.0 years (48% male, 73% SS Sβ⁰ thalassemia) experienced several (mean 3.8 ± 2.0), which were influenced by...
Abstract Background Children with sickle cell anemia (SCA) often develop hyposthenuria and renal hyperfiltration at an early age, possibly contributing to the glomerular injury insufficiency commonly seen later in life. The Phase III randomized double‐blinded Clinical Trial of Hydroxyurea Infants SCA (BABY HUG) tested hypothesis that hydroxyurea can prevent kidney dysfunction by reducing hyperfiltration. Procedure 193 infants (mean age 13.8 months) received 20 mg/kg/day or placebo for 24...
Progress in therapy has made survival into adulthood a reality for most children, adolescents, and young adults with cancer diagnosis today. Notably, this growing population remains vulnerable to variety of long-term therapy-related sequelae. Systematic ongoing follow-up these patients is, therefore, important provide early detection intervention potentially serious late-onset complications. In addition, health counseling promotion healthy lifestyles are aspects care promote risk reduction...
You have accessJournal of UrologyAUA Guideline Articles1 Nov 2021Acute Ischemic Priapism: An AUA/SMSNA Trinity J. Bivalacqua, MD, PhD Bryant K. Allen, MD Gerald Brock, Gregory A. Broderick, Tobias S. Kohler, John P. Mulhall, Jeff Oristaglio, Leila L. Rahimi, MHS Zora R. Rogers, Ryan Terlecki, Landon Trost, Faysal Yafi, andMD Nelson E. BennettMD BivalacquaTrinity Bivalacqua *Correspondence: Perelman Center for Advanced Medicine, University Pennsylvania, Department Urology, 3400 Civic Blvd.,...
Priapism is a persistent penile erection that continues hours beyond, or unrelated to, sexual stimulation and results in prolonged uncontrolled erection. Given its time-dependent progressive nature, priapism situation both urologists emergency medicine practitioners must be familiar with comfortable managing.A comprehensive search of the literature on acute ischemic non-ischemic (NIP) was performed by Emergency Care Research Institute for articles published between January 1, 1960 May 2020....
A questionnaire survey was conducted of patients with homozygous sickle cell anemia (Hb SS) and beta(0)-thalassemia S-beta(0)) between 5 20 years age to determine the prevalence characteristics (number episodes, timing, duration, cause, or precipitating event) priapism. Ninety-eight male their parents were surveyed by same investigator using a structured verbal interview, which modified according patient. Ninety-four had Hb SS four S-beta(0) thalassemia. Eleven (11%) known have experienced...
Abstract Background Early recognition and aggressive treatment of hemophagocytic lymphohistiocytosis (HLH) has changed a uniformly fatal disease to one 55% survive. We examined the diagnosis pediatric patients with HLH from three largest academic medical centers in Texas for information on modern non‐study survival. In contrast previously reported series, racial ethnic composition provided unique opportunity evaluate impact race ethnicity survival HLH. Procedure A retrospective chart review...