A5101774382- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Childhood Cancer Survivors' Quality of Life
- Ethics in Clinical Research
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Bone and Joint Diseases
- Child Nutrition and Water Access
- Virus-based gene therapy research
- Chronic Lymphocytic Leukemia Research
- Hemophilia Treatment and Research
- Venous Thromboembolism Diagnosis and Management
- Trace Elements in Health
- CAR-T cell therapy research
- Patient-Provider Communication in Healthcare
- Central Venous Catheters and Hemodialysis
- Chronic Myeloid Leukemia Treatments
- Viral gastroenteritis research and epidemiology
- RNA Interference and Gene Delivery
- Soft tissue tumor case studies
- Immune Cell Function and Interaction
- Renal and related cancers
- Blood groups and transfusion
- Renal Diseases and Glomerulopathies
Louisiana State University Health Sciences Center New Orleans
2012-2025
Louisiana State University
1998-2025
Children's Hospital of New Orleans
1997-2023
Health & Life (Taiwan)
2019-2023
Action Network
2023
Palmetto Hematology Oncology
2021
University of New Orleans
2005
Baylor College of Medicine
2002
University Medical Center New Orleans
1998
Previously, several individuals with X-linked SCID (SCID-X1) were treated by gene therapy to restore the missing IL-2 receptor gamma (IL2RG) CD34+ BM precursor cells using gammaretroviral vectors. While 9 of 10 patients successfully treated, 4 developed T cell leukemia 31-68 months after therapy. In 2 these cases, blast contained activating vector insertions near LIM domain-only (LMO2) proto-oncogene. Here, we report data on most recent adverse events, which occurred in 7 and 10. patient 10,...
Progress in therapy has made survival into adulthood a reality for most children, adolescents, and young adults with cancer diagnosis today. Notably, this growing population remains vulnerable to variety of long-term therapy-related sequelae. Systematic ongoing follow-up these patients is, therefore, important provide early detection intervention potentially serious late-onset complications. In addition, health counseling promotion healthy lifestyles are aspects care promote risk reduction...
The Children's Oncology Group (COG) Diversity and Health Disparities Committee's (DHDC's) mission is to guarantee the highest standard of care for children adolescents young adults (AYA) with cancer regardless ethnic, racial, gender, or socioeconomic background. We strive identify address issues disparity within existing scientific structure COG support research across improve survival by ensuring equitable access COG-sponsored clinical trials. are committed advance COG-led identifying...
Persons who speak languages other than English are underrepresented in clinical trials, likely part because of inadequate multilevel resources. We conducted a survey institutions affiliated with the Children's Oncology Group (COG) to characterize current research recruitment practices and resources regarding translation interpretation services.
Bruising or bleeding in a child can raise the concern for abuse. Assessing whether findings are result of trauma and/or has disorder is critical. Many disorders rare, and not every with bruising/bleeding that may abuse requires an evaluation disorders. However, some instances, present manner similar to Bleeding cannot be ruled out solely on basis patient family history, no matter how extensive. The history clinical used determine necessity possible disorder, prevalence known presentations...
The American Society of Hematology (ASH) guidelines on treatment pediatric venous thromboembolism (VTE) were published in 2018. In the last 6 years, there has been a 10-fold increase number children involved VTE trials. ASH Committee Quality and Guidelines agreed to update conjunction with International Thrombosis Haemostasis (ISTH). These ASH/ISTH evidence-based are intended support patients, clinicians, other health care professionals management patients VTE. formed multidisciplinary...
Abstract Background Increasing representation in clinical trials is a priority for the National Cancer Institute and Children's Oncology Group (COG). Our survey of COG‐affiliated institutions revealed that many sites have insufficient processes resources to enroll children whose parents use languages other than English (LOE). We describe reported barriers facilitators enrolling when LOE propose opportunities improvement. Procedures sent 20‐item institutions. Five items allowed respondents...
A 3-year-old boy had fever and bone pain. Magnetic resonance imaging of his femurs showed marrow replacement; iliac crest biopsy revealed myelofibrosis. Although the pathologic criteria for Langerhans cell histiocytosis were not met, clinical picture led to treatment with etoposide methylprednisolone, without improvement. One month after presentation, generalized tonic–clonic seizures occurred, magnetic parenchymal brain lesions. 2-chlorodeoxyadenosine was used. Because unexpected lack...
Abstract Background and objectives Hematology/oncology patients have special health needs. To identify barriers to care, we surveyed patients/parents at Children's Hospital of New Orleans 1 year after Hurricane Katrina. We then implemented a “Hurricane Action Plan”—identification families’ evacuation plans each hurricane season's onset; hospital(s) pharmacies in the intended area; updating roadmaps/treatment plans; giving information families requiring hematology/oncology services areas....
Purpose: To report the occurrence of focal segmental glomerulosclerosis (FSGS) in children with acute lymphocytic leukemia (ALL), discuss pathogenesis and problems management. Patients Methods: Progressive renal dysfunction developed two adolescent black girls high-risk ALL who underwent biopsies that were consistent FSGS. In both patients, no known etiologic factors, such as systemic lupus erythematosus. poststreptococcal glomerulonephritis. sickle cell anemia, or acquired immunodeficiency...
Abstract Interleukin (IL)‐10 plays crucial regulatory roles in immune responses by inhibiting the secretion of several cytokines (IL‐2, IL‐12, interferon‐gamma (IFN‐γ)) and lymphocyte proliferation. Iron deficiency, a public health problem for children, alters these responses. To determine whether changes are related to altered IL‐10 secretion, we measured 24 48 h supernatant spleen cell cultures from iron deficient (ID), control (C), pairfed (PF), ID mice fed diet (iron repletion) 3 (R3) 14...
AbstractWe present a case of gamma-delta (γδ) T-cell lymphoma as recurrent event in pediatric liver transplant recipient. Liver transplantation was performed during infancy an 18-month-old black girl because cryptogenic cirrhosis. The patient received immunosuppression with cyclosporine and prednisone. Five years after transplantation, the found to have γδ located retroperitoneal nodes. She chemotherapy did well, remaining disease-free for 6 years. remained only on prednisone prevention...
AbstractThis report describes a rare case of multiple intracranial, extradural chloromas. A five year old African American male presented with headache, fever, and vomiting. The peripheral blood smear showed myeloblasts Auer rods. CTscan the brain three epidural lesions as well son tissue masses in retroorbital region sphenoid sinuses. chest two paraspinal thoracic masses. Pathology intracranial mass revealed granulocytic sarcoma. Cytogenetic analysis simultaneous occurrence oft (8;21)...
A rare case of massive pulmonary embolism is presented in an oligosymptomatic teenager with predisposing factors. Computed tomography angiography supported by three-dimensional reconstruction was diagnostic. The embolus qualified as conventional anatomical guidelines, but low risk more recent functional criteria. Functional assessment has complemented morphologic for stratification adult patients. Such evidence scarce pediatrics. patient underwent surgical embolectomy, followed prophylactic...
Hemophilia B (HB) is caused by an inherited deficiency of plasma coagulation factor IX (FIX). Approximately 60% pediatric patients with HB possess a severe form FIX (<1% activity). Treatment typically requires replacement therapy through the administration FIX. However, exogenous has limited functional half-life, and natural anticoagulant protein S (PS) inhibits activated (FIXa). PS ultimately limits thrombin formation, which coagulation. This regulation FIXa activity led us to test whether...
Fe availability is critical for optimal lymphocyte proliferation; however, the minimum required levels are unknown. Such information valuable when assessing in vitro immune responses Fe-deficient subjects, because serum (Fe) added to culture medium may replete lymphocytes. To address this issue, splenic lymphocytes obtained from seventeen 3-month-old C57BL/6 mice were incubated without and with 1 mg/l concanavalin A or 50 microg/l anti-CD3 antibody media that contained between 0.113 9.74...