A5026343920- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Folate and B Vitamins Research
- Religion, Spirituality, and Psychology
- Bone and Joint Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- Homelessness and Social Issues
- Genital Health and Disease
- Cannabis and Cannabinoid Research
- Syphilis Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Erythrocyte Function and Pathophysiology
- Optimism, Hope, and Well-being
- Kruppel-like factors research
- Parasites and Host Interactions
- Neurological Complications and Syndromes
- Acute Ischemic Stroke Management
- Neonatal Health and Biochemistry
- Trace Elements in Health
- Child Nutrition and Feeding Issues
- Food Security and Health in Diverse Populations
- Multiple Sclerosis Research Studies
- Cerebral Palsy and Movement Disorders
University of North Carolina at Chapel Hill
2009-2020
Pediatrics and Genetics
2019
Cincinnati Children's Hospital Medical Center
2014
University of Minnesota Medical Center
2009
University of Vermont
2009
Kwara State University
2009
Lagos State Health Service Commission
2009
Children's Research Hospital
2009
East Carolina University
2007
St. Jude Children's Research Hospital
2002
Silent cerebral infarcts are the most common neurologic injury in children with sickle cell anemia and associated recurrence of an infarct (stroke or silent infarct). We tested hypothesis that incidence would be lower among who underwent regular blood-transfusion therapy than those received standard care.In this randomized, single-blind clinical trial, we randomly assigned to receive blood transfusions (transfusion group) care (observation group). Participants were between 5 15 years age, no...
We conducted a prospective, multicenter investigation of human-leukocyte antigen (HLA) identical sibling bone marrow transplantation (BMT) in children with severe sickle cell disease (SCD) between 1991 and 2000. To determine if were protected from complications SCD after successful BMT, we extended our initial study BMT for to conduct assessments the central nervous system (CNS) pulmonary function 2 or more years transplantation. In addition, impact on gonadal was studied. After patients...
Objective To determine the extent to which daily stress and mood are associated with pain, health-care use, school activity in adolescents sickle cell disease (SCD). Method Adolescents SCD (n = 37; aged 13 17 years) completed diaries assessing stress, mood, activity, use for up 6 months. Multilevel modeling was used analyze data. Results Daily increases negative were same-day reductions social activity. Increases positive decreases less more participation. Notably, pain predictive of higher...
Children with sickle cell anemia have a higher-than-expected prevalence of poor educational attainment. We test two key hypotheses about attainment among students anemia, as measured by grade retention and use special education services: (1) lower household per capita income is associated attainment; (2) the presence silent cerebral infarct conducted multicenter, cross-sectional study cases from 22 U.S. sites included in Silent Infarct Transfusion Trial. During screening, parents completed...
To investigate mood as a mediator or moderator of the pain-sleep relationship in children with sickle cell disease (SCD).Children SCD (n = 20; aged 8-12 years) completed daily diaries assessing mood, sleep, and pain for up to 2 months. Data was analyzed using multilevel modeling. Results indicate that negative partially mediates between high poor sleep night well following day. The impact on day weakened at increasing levels positive mood.Research is needed fully explore ways may relate...
Objective To investigate the pain-sleep relationship in children with sickle cell disease (SCD) and influence of stress pain medication use on this relationship. Method Children SCD (n = 20; aged 8–12 years) completed daily diaries assessing sleep, pain, stress, for up to 2 months. Data analyzed using multilevel modeling. Results High was related poor sleep quality that night high following day. less sleep. same-day attenuated impact quality.Conclusion highlight importance addressing...
Abstract Background: Pulmonary hypertension (PHT) is reported to be associated with measures of renal function in patients sickle cell disease (SCD). The purpose this exploratory study was determine the relationship between albuminuria and both clinical laboratory variables SCD. Design methods: This cross‐sectional performed using a cohort adult SCD control subjects without Spot urine for microalbumin/creatinine ratio, hemolysis, inflammation other studies were obtained. artery systolic...
Summary Although haematopoietic cell transplantation (HCT) is curative for sickle anaemia (SCA), concerns about its short‐ and long‐term toxicities limit application. A potential toxicity an adverse effect on growth. To identify HCT growth effect, serial height weight measurements from 53 children adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models longitudinal data used analysis. In general was not impaired by in young children;...
To determine whether specific intestinal parasites are associated with HIV infection in Tanzanian children chronic diarrhea.A prospective, cross-sectional study.Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania.All aged 15 months to 5 years admitted diarrhea, and age-matched controls.Standardized history, physical examination, serology, stool parasitology were evaluated for all subjects. We compared three groups: HIV-infected non-HIV-infected diarrhea controls without...
This phase 2 study was designed to characterize the relationship among prasugrel dose, prasugrel's active metabolite (Pras-AM), and platelet inhibition while evaluating safety in children with sickle cell disease. It open-label, multicenter, adaptive design, dose ranging, conducted parts. Part A: Patients received escalating single doses leading corresponding increases Pras-AM exposure VerifyNow®P2Y12 (VN) decreases VNP2Y12 reaction units vasodilator-stimulated phosphoprotein reactivity...
The current study utilized mHealth technologies that were objective (e.g., sleep actigraphy and pulse oximetry) time-sensitive ecological momentary assessments [EMAs]) to characterize in youth with sickle cell disease (SCD) investigate the relationships between variables pain. It also investigated influence of age on sleep-pain relationship.
The pathophysiology of pulmonary hypertension (PHT) in sickle cell disease (SCD) is probably multifactorial. Soluble fms-like tyrosine kinase-1 (sFLT-1) a member the vascular endothelial growth factor receptor (VEGFR) family. By adhering to and inhibiting VEGF placenta factor, it induces dysfunction. We sought evaluate association sFLT-1 with clinical complications SCD. confirmed that was significantly elevated SCD patients compared healthy, race-matched control subjects. level higher PHT,...
Abstract This study explored the relation among pain, stress, and sleep in 24 children with sickle cell disease aged 8 to 12 years. Children their parents completed a baseline assessment of children's sleep. Following assessment, daily diary assessing these variables for up weeks. Children's reports appeared fairly consistent parents' diaries. Results from regression models indicated that high pain severity was related poor quality this exacerbated at higher levels stress. Understanding way...
Vasculopathy of the large vessels commonly occurs in sickle cell disease, and as a result cerebral infarction is well characterized complication this condition. However, spinal appears to be rare. Spinal infarct infrequent non-sickle population well, accounts for only about 1 percent all central nervous system infarcts.In present work, we report case 19-year-old African-American man with disease who experienced an anterior subsequent quadriplegia. He was incidentally noted heterozygote...
Youth with sickle cell disease (SCD), a genetic disorder of red blood cells, may experience acute pain episodes lasting 2 to 3 days on average. While existing research has demonstrated associations between SCD and poor social functioning in youth SCD, there are no data whether symptoms depression anxiety modify the relationship functional outcomes pediatric populations. It was hypothesized that more would exacerbate high SCD.We conducted cross-sectional study 114 their guardians assessing...