A5049404381- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Hemophilia Treatment and Research
- Blood groups and transfusion
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Bone and Joint Diseases
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myeloid Leukemia Research
- Virus-based gene therapy research
- Prenatal Screening and Diagnostics
- Kawasaki Disease and Coronary Complications
- Chronic Myeloid Leukemia Treatments
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Metabolism and Genetic Disorders
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Neurological Complications and Syndromes
- CAR-T cell therapy research
- Cannabis and Cannabinoid Research
- Cancer-related gene regulation
- Child and Adolescent Health
- Religion, Spirituality, and Psychology
Center for Cancer and Blood Disorders
2017-2024
Children's National
2017-2024
George Washington University
2017-2023
George Washington University Hospital
2022
National Hospital
2022
University of Mississippi Medical Center
2010-2021
Jackson Memorial Hospital
2010-2021
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2017
University of Milan
2017
University of Mississippi
2008-2014
The prevention of bleeding with adequately sustained levels clotting factor, after a single therapeutic intervention and without the need for further medical intervention, represents an important goal in treatment hemophilia.
Silent cerebral infarcts are the most common neurologic injury in children with sickle cell anemia and associated recurrence of an infarct (stroke or silent infarct). We tested hypothesis that incidence would be lower among who underwent regular blood-transfusion therapy than those received standard care.In this randomized, single-blind clinical trial, we randomly assigned to receive blood transfusions (transfusion group) care (observation group). Participants were between 5 15 years age, no...
The development of neutralizing anti–factor VIII alloantibodies (inhibitors) in patients with severe hemophilia A may depend on the concentrate used for replacement therapy.
Stroke is a traumatic complication in sickle cell anaemia (SCA) that associated with significant morbidity and risk of recurrent overt stroke 2·2-6·4 events per 100 patient-years. A retrospective study was performed on all paediatric SCA patients diagnosed history between 1997 2010. total 31 children had new onset stroke. The mean age the active (n = 27) 17·9 years (range 6·8-27·6 years) period observation 305 Twenty-two 27 (81%) were receiving long term red blood transfusions 16 (59%)...
Although effective agents are available to prevent painful vaso-occlusive episodes of sickle cell disease (SCD), there no disease-modifying therapies for ongoing episodes; treatment remains supportive. A previous phase 3 trial poloxamer 188 reported shortened duration in SCD, particularly children and participants treated with hydroxyurea.To reassess the efficacy episodes.Phase 3, randomized, double-blind, placebo-controlled, multicenter, international conducted from May 2013 February 2016...
Pediatric cancer is associated with a host of negative psychosocial consequences; however, outcomes vary extensively suggesting need to better understand this variation. Empirical research suggests positive association between time since diagnosis (TSD) and Quality Life (QoL). In addition TSD, family stressors have been found be particularly important in predicting QoL among children. The current study examined parental chronic stress beyond TSD explanation functioning sample pediatric...
A geographical and causal connection has long been recognized between malaria, Epstein-Barr virus (EBV) infection Burkitt's lymphoma (BL), but the underlying mechanisms remain obscure. Potential clues are that malaria parasite Plasmodium falciparum selectively absorbs vitamin from host depends on it for its biological activities; secondly, alterations in (retinoid) metabolism have implicated many forms of cancer, including BL. The first author proposed merozoite-stage parasite, emerging...
The state of Mississippi has consistently been ranked as the with most number obese people in United States prevalence rates >30%. Our aims this study were to estimate overweight and obesity children adults diagnosed haemophilia Mississippi, assess whether race/ethnicity severity are important risk factors. A retrospective chart review was performed for all haemophilic patients seen at Hemophilia Treatment Center. Patients classified into two major age groups: 2-19.9 years > or =20 years....
This study examined the temporal relationship between physical activity, fluid intake, and daily pain in children with sickle cell disease (SCD) frequent pain.A total of 30 African American ( M age = 13.9; 53% female; 76.3% type SS) who reported more than or equal to once every 2 weeks their parents completed measures anxiety/depressive symptoms. Children then a diary wore activity Actiwatch for 14 days at home.Contrary physiological theory-based hypotheses, lower was associated greater...
Acute chest syndrome (ACS) is a common and serious lung complication in sickle cell disease. A retrospective medical chart review was performed over 6-year period all pediatric ACS patients to investigate whether factors during the initial hospitalization were associated with recurrent episodes. There 386 episodes of ACS: 149 had only 1 episode ACS, 76 >1 ACS; 172 (76.4%) hemoglobin SS, 39 (17.3%) SC. The most presenting features fever (83%), pain (70%), cough (61%), which changed number...
Abstract Pheochromocytoma and paraganglioma (PGL) are rare neuroendocrine tumors in children. Apparently sporadic cases of PGL may harbor germline mutations the succinate dehydrogenase ( SDHx ) gene. SDHB associated with malignant disease. We report a 13‐year‐old African American boy diffusely metastatic compound heterozygous mutation leading to novel splice donor region DNA sequence variant Family history was positive for non‐classical congenital adrenal hyperplasia pituitary adenoma. After...
The authors studied pediatric patients with B-precursor acute lymphocytic leukemia (ALL) to determine whether Mississippi’s gender incidences correlate national statistics. Furthermore, data on in each of the risk categories low, standard, and high were collected. A retrospective chart review was performed ALL diagnosed at Children’s Cancer Clinic University Mississippi Medical Center from 1995 2005. found be comparable average for (1.34:1 vs 1.3:1) overall. However, includes T-cell ALL,...