A5027063444- Hemophilia Treatment and Research
- COVID-19 and healthcare impacts
- Platelet Disorders and Treatments
- COVID-19 Clinical Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- Sepsis Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Research on Leishmaniasis Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related gene regulation
- Hemoglobinopathies and Related Disorders
- Monoclonal and Polyclonal Antibodies Research
- Machine Learning in Healthcare
- COVID-19 epidemiological studies
- Body Contouring and Surgery
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Iron Metabolism and Disorders
- COVID-19 and Mental Health
- Blood groups and transfusion
- Heparin-Induced Thrombocytopenia and Thrombosis
- Bone fractures and treatments
- Genomics and Rare Diseases
- Genomics and Phylogenetic Studies
- Long-Term Effects of COVID-19
- Orthopedic Surgery and Rehabilitation
Leiden University Medical Center
2014-2024
University of Milan
2021-2024
Infectious Diseases Data Observatory
2023-2024
University of Oxford
2022-2024
Angkor Hospital for Children
2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2024
Nuffield Orthopaedic Centre
2022-2024
Imperial College Healthcare NHS Trust
2024
University of Amsterdam
2023
Amsterdam University Medical Centers
2023
Background Treatment of patients with hemophilia has advanced over the past decades, but it is unknown whether this resulted in a normal life expectancy Netherlands. Objective This observational cohort study aimed to assess all-cause and cause-specific mortality Netherlands between 2001 2018 compare previous survival assessments from 1973 onward. Patients/methods All 1066 who participated nationwide survey were followed until July 2018. Results Information on 1031 individuals (97%) was...
Abstract Emicizumab is approved for prophylaxis of patients with hemophilia A (HA). Despite its efficacy in reducing bleeding, some on emicizumab still experience hemarthrosis, but no tool yet available to identify those at a higher risk spontaneous joint bleeding. This study aimed evaluate whether laboratory measurements (global coagulation assays and concentration) and/or arthropathy scores can distinguish bleeding while prophylaxis. thrombin generation assay was performed upon the...
Sixty-two centres in 16 countries contributed with 2,694 open fractures cases to an international, multi-centric, retrospective cohort study involving different healthcare settings. The INTELLECT results show that there are significant disparities on the management of lower limb internationally. A timely, multidisciplinary, guideline-directed care is a protective factor for developing infective complications, non-union and requiring amputation.
<ns5:p>Background Lassa fever (LF) is an endemic and immediately notifiable disease in Liberia, one laboratory confirmed case constitutes outbreak. We described the epidemiological characteristics hospital outcomes of LF cases hospitalized during 2022-2023 outbreak Liberia. Methods A retrospective cohort study was conducted using routine surveillance data from Descriptive statistics were used to summarize log binomial regression assess association between mortality. Results total 439...
Introduction: Chronic kidney disease (CKD) develops in approximately 40% of patients with diabetes. The prevalence CKD Malaysia is 9.07% among adults. It important to obtain accurate local data on patient Type 2 Diabetes Mellitus (T2DM) facilitate health-care planning including the review priorities, program activities, and allocation resources. objective this study determine DM. We further explored association between glycaemic control, eGFR adverse outcomes (cardiovascular events,...
<ns3:p>Background The coronavirus disease 2019 (COVID-19) has caused substantial morbidity and mortality on a global scale. A strong correlation been found between COVID-19 treatment outcomes noncommunicable diseases such as cancers. However, there is limited information the of cancer patients who were hospitalised for COVID-19. Methods We conducted an analysis data collected in large prospective cohort study set-up by International Severe Acute Respiratory Emerging Infection Consortium...
Abstract Advances in long-read sequencing have enabled routine complete assembly of human genomes, but much remains to be done represent broader populations and show impact on disease-gene discovery. Here, we report highly accurate, near-complete phased genomes from six Middle Eastern (ME) family trios ( n = 18) with neurodevelopmental conditions, representing ancestries Sudan, Jordan, Syria, Qatar Afghanistan. These revealed 42.2 Mb new sequence (13.8% impacting known genes), 75 HLA/KIR...
The Patient-Reported Outcomes Measurement Information System (PROMIS) Profile-29 questionnaire is widely used worldwide, but it has not yet been validated in the Netherlands, nor persons with hemophilia.To validate Dutch-Flemish version of PROMIS-29 Profile v2.01 adults hemophilia.Dutch males hemophilia (all severities) completed questionnaires that contained sociodemographic and clinical characteristics, PROMIS-29, RAND-36, Hemophilia Activities List (HAL). Structural validity each subscale...
Although sports participation is advocated in people with haemophilia (PWH), detailed data concerning Dutch PWH lacking.to assess (6-65 years) compared to the general population (GP).Data from a nationwide, cross-sectional study were analysed. Sports (type, duration, frequency) was assessed by Modifiable Activities Questionnaire (MAQ), limitations activities using (Paediatric) Haemophilia List ((Ped)HAL). two highest categories according National Hemophilia Foundation classification...
Treatment availability and comprehensive care have resulted in improved clinical outcomes for persons with hemophilia. Recent data on socioeconomic participation the Netherlands are lacking. This study assessed education, labor market, social hemophilia compared general male population.
Anti-factor VIII (FVIII) antibodies have been reported to exhibit both neutralizing and non-neutralizing characteristics. This is the first study investigating full spectrum of FVIII-specific antibodies, including very-low titer inhibitors, in a large nationwide population persons with hemophilia A all severities. All (mild (FVIII > 5-40 IU/dL)/moderate [FVIII 1-5 IU/dL)/severe < 1 IU/dL)] an available plasma sample who participated sixth Hemophilia Netherlands between 2018 2019 were...
BackgroundHemophilia care has improved greatly because of advances in treatment options and comprehensive care. In-depth insight into the perspectives persons with hemophilia health providers on their may provide targets for further improvements.ObjectivesTo assess satisfaction population care, to explore factors determining satisfaction, identify areas potential improvements, including digital tools.MethodsFirst, data from a nationwide, cross-sectional questionnaire among 867 adult...
Persons with hemophilia and hepatitis C virus (HCV) infection have a lower health-related quality of life (HRQoL) than those never HCV infected. However, it is unknown whether HRQoL after eradication comparable to individuals We aimed compare between HCV-cured chronically HCV-infected persons hemophilia.
Objective Interprofessional education (IPE) is increasingly recognized as crucial for effective healthcare delivery. This study aimed to assess the perceptions of medical and nursing students in Pakistan using Attitude Scale (IPAS). Methods A cross-sectional survey was conducted across various institutions Pakistan. total 465 (65% medical, 35% nursing) completed 27-item IPAS questionnaire, which administered online. Demographic data previous experience were also collected. The tool validated...