A5045328254- Growth Hormone and Insulin-like Growth Factors
- Hypothalamic control of reproductive hormones
- Hormonal and reproductive studies
- Diabetes Management and Research
- Child and Adolescent Psychosocial and Emotional Development
- Ovarian function and disorders
- Neurological Disorders and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Adolescent and Pediatric Healthcare
- Diabetes and associated disorders
- Pesticide Residue Analysis and Safety
- Alzheimer's disease research and treatments
- Childhood Cancer Survivors' Quality of Life
- Bone and Dental Protein Studies
- Vector-Borne Animal Diseases
- Membrane Separation Technologies
- Pancreatic function and diabetes
- Vector-borne infectious diseases
- Thyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Obesity, Physical Activity, Diet
- Biochemical and Molecular Research
- Oral microbiology and periodontitis research
- Thyroid Cancer Diagnosis and Treatment
University of Mississippi Medical Center
2002-2020
Mississippi Academy of Sciences
2020
Jackson Memorial Hospital
1993-2018
Jackson College
2018
University of Southern Mississippi
2006-2011
University of Alabama
2011
University Hospital Bonn
1993
University of Chicago
1977-1990
University of Würzburg
1988-1990
Kurt J. Lesker (United Kingdom)
1987
Familial male-limited precocious puberty is a autosomal dominant condition. It characterized by increased testosterone synthesis in the absence of testicular stimulation luteinizing hormone (LH). We hypothesised that an abnormal configuration LH receptor might autonomously activate G protein coupling, and thereby cause overproduction this To test hypothesis, we screened for mutations part gene important binding. DNA sequence variation was detected 2 out 5 families with single strand...
• We tested the concept that estrogen directly stimulates growth hormone (GH) production by determining whether low-dose treatment with ethinyl estradiol increases GH reserve, as assessed levodopa administration, without inhibiting somatomedin-C (Sm-C) levels. Twenty-three prepubertal short normal children underwent tests before and after being treated estradiol. One bedtime dose of (20 to 40 μg/sq m, n = 8) resulted in a significant increase levels during testing, no change Sm-C (0.27±0.03...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMyosin-product complex and its effect on the steady-state rate of nucleoside triphosphate hydrolysisEdwin William Taylor, Richard W. Lymn, George MollCite this: Biochemistry 1970, 9, 15, 2984–2991Publication Date (Print):July 21, 1970Publication History Published online1 May 2002Published inissue 21 July 1970https://doi.org/10.1021/bi00817a008Request reuse permissionsArticle Views99Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are...
Objective Type 1 diabetes (T1DM) is a chronic life-threatening disease that requires strict adherence to daily treatment tasks. Although necessary for survival, children who present with behavior problems tend show complying the regimen, thereby increasing their risk morbidity and premature mortality. The of poor hypothesized be lower these children, however, if they engage in more routine behaviors. Given potential clinical implications, this hypothesis two theoretical models proposed...
We have employed a flow dialysis technique (FDT) to describe the interactions of estradiol (E2), testosterone (T), testosterone-estradiol-binding globulin (TEBG), and albumin in undiluted, 37 C plasma with negligible disturbance equilibrium. The percentages free E2 T were measured simultaneously, both without addition exogenous T, found correlate closely rectangular hyperbolic relationship which approximated linearity normal range. A physical chemical model was developed fit these data....
Testosterone binding to plasma has been analyzed under physiological conditions. Flow dialysis technique (FDT) permitted precise studies of whole 37 C with negligible disturbance the equilibrium state. The information obtained by FDT was compared that a charcoal adsorption assay (CA), which primarily assesses testosterone totestosterone-estradiol-binding globulin (TEBG). results two methods correlated closely(r = 0.98). Consequently, percentage free in vivo conditions could be readily...
ABSTRACT Monoamine oxidase‐B (MAO‐B) activity of platelets an age‐ and sex‐matched group controls was compared with several groups inpatients having non‐familial dementia Alzheimer type (DAT), Parkinson's disease (PD), multi‐infarct (MID), mixed types these 3 diseases a other central nervous system (CNS) organic disorders. All patients were subjected to psychometric tests, including the Sandoz Clinical Assessment ‐ Geriatric Scale, Hamilton Rating Scale for Depression, Mini‐Mental State...
HYPODIPSIC hypernatremia is an uncommon syndrome that has been observed in children and adults with various congenital or acquired diseases of the brain.1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 The characterized by chronic recurrent episodes severe associated dehydration a lack thirst. In all previous carefully evaluated cases, hypodipsia some defect secretion antidiuretic hormone arginine vasopressin.1 , Often, vasopressin clinically inapparent can be...
To validate a three-factor model for the Pediatric Symptom Checklist-17 (PSC-17) and evaluate its diagnostic accuracy with African-American Caucasian children without chronic illness.Mothers of 723 youth diagnosed either type I diabetes (n = 210) or sickle cell disease 191) nonill peer group 322) completed demographic questionnaire, PSC-17, Child Behavior Checklist (CBCL).Confirmatory factor analyses tests measurement invariance validated structure PSC-17 illness. Receiver operating...
Herein, we report mutation analysis of the LH receptor gene in 17 males with LH-independent precocious puberty, which 8 were familial and 9 had a negative family history. A total 7 different mutations (all previously reported) detected 12 patients. Among 10 European male-limited puberty (FMPP) patients who mutation, none Asp578Gly is responsible for vast majority cases U.S. The restricted number activating observed this other studies FMPP strongly suggests that an phenotype associated very...
The use of polyethyleneimine-cellulose thin layer sheets to follow the phosphorylation histone and decomposition ATP catalyzed by an adenosine 3':5'-monophosphate (cyclic AMP)-stimulated protein kinase, kinase I, has made possible a more detailed analysis time course these reactions than been achieved previously be observing only recovered phosphorylated protein. When [gamma-32P] was employed, significant error introduced presence 32Pi at solvent front on sheets, this limited accuracy...
We explored the possibility that evaluation of serum bioactive LH (B-LH) reserves in response to an intensive (high dose; 4 h) gonadotropin-releasing hormone (GnRH) infusion might provide additional insight into normal and abnormal pubertaJ maturation. Controls consisted 24 boys 10 men; hypopituitary cases (11–53 yr age) were studied. Maturation was staged by morning testosterone levels, as well clinically. B-LH assayed rat Leydig cell production; immunoreactive (I-LH) RIA. In control...
The psychometric properties and factor structure of a widely used screening measure for behavioral emotional dysfunction, the Pediatric Symptom Checklist (PSC), was extended to population chronically ill children. Parents 404 children ranging from 6 17 years age diagnosed with either insulin-dependent diabetes mellitus (IDDM) or sickle cell disease (SCD) completed PSC while waiting routine medical appointment. measure's internal consistency found be high, Cronbach's alpha = .89, test-retest...
We have employed a perifusion technique to explore the time course and specificity of 17β-estradiol (E2) effects directly upon luteinizing hormone (LH) release from isolated rat anterior pituitary under pulsatile releasing (LHRH) stimulation. first characterized system fitted data simple dose-response model. Multiple studies were then performed with pulses LHRH at approximately half-maximal response concentration (10−8 M); LH responses an initial pulse (#1) compared second (#2) given...
The apparent association constant of testosterone binding to pure human serum albumin was found be significantly less at 5 g/dl (1.79 X 104 M-1) than 1 (2.29 M-1). This demonstrates that the common assumption site characteristics are with protein dilution is not strictly valid. Determination percent free normal concentrations by equilibrium dialysis may also in error 20% or more due fluid shifts within test system.
Abstract Pheochromocytoma and paraganglioma (PGL) are rare neuroendocrine tumors in children. Apparently sporadic cases of PGL may harbor germline mutations the succinate dehydrogenase ( SDHx ) gene. SDHB associated with malignant disease. We report a 13‐year‐old African American boy diffusely metastatic compound heterozygous mutation leading to novel splice donor region DNA sequence variant Family history was positive for non‐classical congenital adrenal hyperplasia pituitary adenoma. After...
We evaluated a GnRH agonist (GnRHa) asa potential single stimulus to both pituitary and ovarian secretion i n 13 girls with true precocious puberty. compared the [6-D-(2-naphthyl)alanine]GnRH acetate (nafarelin, Syntex) administered as sc injection of 0.2μg/kg infused iv in dose ofμg/kg-h for3h assessed response plasma steroid intermediates estradiol (E2) bio synthesis. Although serum LH FSH levels increased similar peaks 3 h after commencing nafarelin testing, they rose faster (P<0.01 at...
cyclic AMP, adenosine 3':5'-monophosphate;Mes, 2-(N-morpholino)ethanesulfonic acid; [y-32PlATP,