A5004752879- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bone and Joint Diseases
- Prenatal Screening and Diagnostics
- Erythrocyte Function and Pathophysiology
- Folate and B Vitamins Research
- Cancer-related molecular mechanisms research
- Pharmacological Effects and Toxicity Studies
- Angiogenesis and VEGF in Cancer
- Kruppel-like factors research
- Parvovirus B19 Infection Studies
- Food Security and Health in Diverse Populations
- Potassium and Related Disorders
- Reproductive Health and Contraception
- Cannabis and Cannabinoid Research
- Opioid Use Disorder Treatment
- Economic and Financial Impacts of Cancer
- Trace Elements in Health
- Poisoning and overdose treatments
- Erythropoietin and Anemia Treatment
- RNA modifications and cancer
- Advanced MRI Techniques and Applications
- Atherosclerosis and Cardiovascular Diseases
Emory University
2021-2024
Children's Healthcare of Atlanta
2011-2024
Aflac (United States)
2021-2024
Morehouse School of Medicine
2013-2024
Center for Cancer and Blood Disorders
2021-2023
Emory and Henry College
2015-2022
St. Jude Children's Research Hospital
2002
Children's Hospital of Philadelphia
2002
Rho (United States)
2002
Duke University Hospital
2002
More than half a century after the discovery of molecular basis Sickle Cell Disease (SCD), causes phenotypic heterogeneity disease remain unclear. This manifests with different clinical outcomes such as stroke, vaso-occlusive episodes, acute chest syndrome, avascular necrosis, leg ulcers, priapism and retinopathy. These cannot be explained by single mutation in beta-globin gene alone but may attributed to genetic modifiers environmental effects. Recent advances post human genome sequence era...
Finding a widely available cure for sickle cell anemia (HbSS) still remains challenge one hundred years after its discovery as genetically inherited disease. However, growing interest in the nutritional problems of disease has created body literature from researchers seeking alternatives means decreasing morbidity and improving quality life among HbSS patients. This review demonstrates that over past 30 role protein/energy deficiency been more clearly defined via direct measurements, leading...
Sickle cell anemia (HbSS) includes chronic inflammation, but the origin is unclear. We hypothesized that in stable HbSS patients inflammation was associated with hypermetabolism. compared selected hypermetabolic and key Immuno-modulator indicators versus control children examined associations between measures of hypermetabolism inflammation. Twelve fasting asymptomatic 6–12 years 9 controls matched for age, gender fat mass (FM) were studied. Proportional reticulocyte count (retic%) resting...
Summary Transcranial Doppler ( TCD ) With Transfusions Changing to Hydroxyurea TW i TCH trial is a randomized, open‐label comparison of hydroxycarbamide (also termed hydroxyurea) versus continued chronic transfusion therapy for primary stroke prevention in patients with sickle cell anaemia SCA and abnormal . Severity location iron overload an important secondary outcome measure. We report the baseline findings abdominal organ burden 121 participants. At enrollment, were young (9·8 ± 2·9...
ABSTRACT Objectives: We hypothesized that an elevated hemoglobin synthesis rate (SynHb) and myocardial oxygen consumption (MVO 2 ) contribute to the excess protein energy metabolism reported in children with sickle cell anemia. Patients Methods: Twelve (6–12 years old) asymptomatic 9 healthy matched for age sex were studied. Measurements whole‐body turnover by [1‐ 13 C]leucine, SynHb [ 15 N]glycine, resting expenditure indirect calorimetry systolic blood pressure–heart product used as index...
ABSTRACT Background Patients with sickle cell disease (SCD) experience painful vaso‐occlusive episodes that increase age; a subset develops chronic pain (CP). CP is usually managed acute management guidelines despite evidence of ineffectiveness. Buprenorphine (BUP), partial opioid agonist, potent analgesic less euphoric effect and respiratory “ceiling effect.” BUP therefore provides an alternative “harm reduction” approach for in pediatric SCD patients. Methods This single urban center...
Stroke is one of the most disabling complications sickle cell anemia (SCA). The molecular mechanisms leading to stroke in SCA or by which packed red blood (PRBC) transfusion prevents strokes are not understood. We investigated effects PRBC on serum biomarkers children with who were at high‐risk for stroke. Serum samples from 80 subjects analyzed, including baseline, study exit time point and 1 year after exit. Forty randomized standard care 40 arm. Samples assayed levels BDNF, sVCAM‐1,...
Hypercoagulability in sickle cell disease (SCD) is associated with multiple SCD phenotypes, association stroke risk has not been well described. We hypothesized that serum levels of biomarkers coagulation activation correlate high transcranial Doppler ultrasound velocity and decreases blood transfusion therapy patients. Stored samples from subjects the Stroke Prevention Sickle Cell Anemia (STOP) trial were analyzed using ELISA protein multiplexing techniques. 40 each treatment arm (Standard...
Pain is a common complication of sickle cell disease. Sickle pain can often be effectively managed by pediatricians in outpatient and hospital settings. Acute management should initiated quickly. Patients need to evaluated for complications other causes pain. Nonsteroidal anti-inflammatory drugs opioids are the mainstay treatment, but additional therapies include hydration, local control, muscle relaxants, nonpharmacologic approaches. Healthy lifestyle habits good behavioral mental health...
Whole transcriptome RNA-sequencing was performed to quantify RNA expression changes in whole blood samples collected from steady state sickle cell anemia (SCA) and control subjects. Pediatric SCA subjects were recruited Atlanta (GA)—based hospital(s) systems consented for sequencing. sequencing on an Ion Torrent S5 sequencer, using the Total RNA-seq v2 protocol. Data aligned hg19 reference genome analyzed Partek Genomics studio package (v7.0). 223 genes differentially expressed between...
Discussions regarding gonadal function and possible disease or treatment-related ovarian testicular dysfunction, sexual future infertility can be challenging in the sickle cell (SCD) pediatric care setting. A construct that stratifies topics into those are time sensitive require reproductive expertise vs address health as a part of normal SCD may helpful. Pediatric discussions function/dysfunction for patients with include (1) time-sensitive fertility consults preceding start gonadotoxic...
To determine the acceptability, feasibility and safety of yoga for chronic pain in sickle cell disease. In Part A this two-part study, adolescents with SCD (Group 1) their parent 2) completed a survey designed to capture characteristics, attitudes practices related yoga, potential acceptability program. B, study assessed an instructor-led group The was registered on clinicaltrials.gov (NCT03694548). Eight sessions. Feasibility outcomes were chosen priori, as follows: Proportion adolescent...
<h3>Importance</h3> The incidence of and mortality from coronary heart disease (CHD) are substantially higher among African American individuals compared with non-Hispanic White individuals, even after adjusting for traditional factors associated CHD. unexplained excess risk might be due to genetic related ancestry that a CHD, such as the heterozygous state sickle cell variant or trait (SCT). <h3>Objective</h3> To evaluate whether there is an association between SCT myocardial infarction...
We studied the number and function of angiogenic progenitor cells growth factors in children aged 5–18 years without acute illness, 43 with Hemoglobin SS 68 normal hemoglobin. subjects had at least twice as many mononuclear cell colonies more circulating than Control subjects. Plasma concentrations erythropoietin, angiopoietin-2, stromal-derived factor (SDF)-1 α were significantly higher compared to In a multivariate analysis model, SDF-1 concentration was found be associated both CPC total...