A5090590649- Malaria Research and Control
- Mosquito-borne diseases and control
- Complement system in diseases
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Opioid Use Disorder Treatment
- Parasites and Host Interactions
- Pain Management and Opioid Use
- interferon and immune responses
- Child Nutrition and Water Access
- Poisoning and overdose treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Multiple Myeloma Research and Treatments
- Chemokine receptors and signaling
- Syphilis Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Parasitic Infections and Diagnostics
- Prenatal Substance Exposure Effects
- Animal Virus Infections Studies
- Pharmacovigilance and Adverse Drug Reactions
- Global Maternal and Child Health
- Cancer, Hypoxia, and Metabolism
- Calpain Protease Function and Regulation
- Kruppel-like factors research
Morehouse School of Medicine
2009-2022
Centers for Disease Control and Prevention
2015-2021
Division of Parasitic Diseases and Malaria
2015-2021
Center for Global Health
2015-2021
National Vital Statistics System
2020
National Center for Injury Prevention and Control
2018-2019
University of Ghana
2008-2017
Korle Bu Teaching Hospital
2008-2017
Epidemic Intelligence Service
2015
Howard University
2008
The 63,632 drug overdose deaths in the United States 2016 represented a 21.4% increase from 2015; two thirds of these involved an opioid (1). From 2015 to 2016, increased all categories examined; largest occurred among involving synthetic opioids other than methadone (synthetic opioids), which includes illicitly manufactured fentanyl (IMF) Since 2013, driven largely by IMF, including analogs (2-4), current wave epidemic has been marked increases opioids. IMF contributed deaths, with...
From 2017 to 2018, U.S. overdose death rates involving synthetic opioids (excluding methadone) increased by 10%, heroin decreased 4%, and prescription opioid-involved 13.5%.
In 2017, among 70,237 drug overdose deaths, 47,600 (67.8%) involved opioids, with increases across age groups, racial/ethnic county urbanization levels, and in multiple states. From 2013 to synthetic opioids contributed death rates several 2016 opioid-involved increased 45.2%.
In 2016, a total of 63,632 persons died from drug overdoses in the United States (1). Drug overdose deaths involving cocaine, psychostimulants with abuse potential (psychostimulants), or both substances combined increased 42.4% 12,122 2015 to 17,258 2016.* Psychostimulants include drugs such as methamphetamine, 3,4-methylenedioxy-methamphetamine (MDMA), dextroamphetamine, levoamphetamine, methylphenidate (Ritalin), and caffeine. From cocaine-involved psychostimulant-involved death rates...
Abstract Background Plasmodium falciparum can cause a diffuse encephalopathy known as cerebral malaria (CM), major contributor to associated mortality. Despite treatment, mortality due CM be high 30% while 10% of survivors the disease may experience short- and long-term neurological complications. The pathogenesis other forms severe is multi-factorial appear involve cytokine chemokine homeostasis, inflammation vascular injury/repair. Identification prognostic markers that predict severity...
Abstract Background Plasmodium falciparum in a subset of patients can lead to cerebral malaria (CM), major contributor malaria-associated mortality. Despite treatment, CM mortality be as high 30%, while 10% survivors the disease may experience short- and long-term neurological complications. The pathogenesis is mediated by alterations cytokine chemokine homeostasis, inflammation well vascular injury repair processes although their roles are not fully understood. hypothesis for this study...
In sub-Saharan Africa, approximately 30 million pregnant women are at risk of contracting malaria annually. Nearly 36% healthy receiving routine antenatal care tested positive for Plasmodium falciparum HRP-II antigen in Ghana. We the hypothesis that asymptomatic HRP II expressed a unique Th1 and Th2 phenotype differs from controls. Plasma (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>15</mml:mn></mml:math>)...
Plasmodium falciparum in a subset of patients can lead to diffuse encephalopathy known as cerebral malaria (CM). Despite treatment, mortality caused by CM be high 30% while 10% survivors the disease may experience short- and long-term neurological complications. The pathogenesis involves alterations cytokine chemokine expression, local inflammation, vascular injury repair processes. These diverse factors have limited rate discovery prognostic predictors fatal CM. Identification reliable...
Plasmodium falciparum in a subset of patients can lead to diffuse encephalopathy known as cerebral malaria (CM). Despite treatment, mortality caused by CM be high 30% while 10% survivors the disease may experience short- and long-term neurological complications. The pathogenesis involves alterations cytokine chemokine expression, local inflammation, vascular injury repair processes. These diverse factors have limited rate discovery prognostic predictors fatal CM. Identification reliable...
SUMMARY The 2013 multistate outbreaks contributed to the largest annual number of reported US cases cyclosporiasis since 1997. In this paper we focus on investigations in Texas. We defined an outbreak-associated case as laboratory-confirmed a person with illness onset between 1 June and 31 August 2013, no history international travel previous 14 days. Epidemiological, environmental, traceback were conducted. Of 631 outbreaks, Texas greatest cases, 270 (43%). More than 70 clusters identified...
Abstract Background The mechanisms underlying the pathogenesis of cerebral malaria (CM) syndrome are not well understood. Previous studies have shown a strong association inflammatory chemokines, apoptotic markers and angiogenic molecules with CM associated mortality. Recognizing importance angiopoietins (ANG) in CM, retrospective investigation was carried out hospital cohort patients Plasmodium infection central India to determine if these factors could be suitable severity. Methods...
Pregnancy in sickle cell disease (SCD) patients is associated with increased risk of maternal and fetal mortality. This study determines pregnancy outcomes among women SCD delivering at Korle-Bu Teaching Hospital, Accra, Ghana. Nine hundred sixty (960) medical records pregnant (131 HbSS, 112 HbSC, 717 comparison group) from 2007 to 2008 were reviewed. The HbSS eclampsia (adjusted odds ratio [AOR] = 10.56, 95% confidence interval [CI] 3.60–30.96, P < 0.001), intrauterine growth restriction...
Despite appropriate anti-malarial treatment, cerebral malaria (CM)-associated mortalities remain as high 30%. Thus, adjunctive therapies are urgently needed to prevent or reduce such mortalities. Overproduction of CXCL10 in a subset CM patients has been shown be tightly associated with fatal human CM. Mice deleted gene partially protected against experimental (ECM) mortality indicating the importance pathogenesis However, direct effect increased production on brain cells is unknown. We...
The effectiveness of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) against malaria and anemia is unclear because the spread SP-resistant Plasmodium falciparum . This study evaluates IPTp-SP among pregnant women attending antenatal clinic at Korle-Bu Teaching Hospital in Accra, Ghana. A cross-sectional comparing prevalence using non-IPTp-SP users was conducted June–August 2009. total 363 (202 IPTp 161 non-IPTp users) were recruited. 15.3% had...
Human cerebral malaria (HCM) is a severe form of characterized by sequestration infected erythrocytes (IRBCs) in brain microvessels, increased levels circulating free heme and pro-inflammatory cytokines chemokines, swelling, vascular dysfunction, coma, mortality. Neuregulin-1β (NRG-1) encoded the gene NRG1, member family polypeptide growth factors required for normal development nervous system heart. Utilizing an experimental (ECM) model (Plasmodium berghei ANKA C57BL/6), we reported that...
Cerebral Malaria (CM) is a diffuse encephalopathy caused by Plasmodium falciparum infection. Despite availability of antimalarial drugs, CM-associated mortality remains high at approximately 30% and subset survivors develop neurological cognitive disabilities. While antimalarials are effective clearing parasites they do little to protect against CM pathophysiology parasite-induced brain inflammation that leads seizures, coma long-term sequelae in patients. Thus, there urgent need explore...
Detection of Plasmodium falciparum parasites in patients with malaria necessitates drawing blood, which increases the risk accidental infections and is poorly accepted communities blood taboos. Thus, non-invasive, cost-effective tests that minimize need for collection are needed. histidine-rich protein II ( Pf HRP II) levels plasma saliva were compared malaria–positive –negative Ghana. Plasma obtained from 30 thick-film positive 10 negative children evaluated by ELISA. Among smear, 16 (53%)...
We have previously reported that free Heme generated during experimental cerebral malaria (ECM) in mice, is central to the pathogenesis of fatal ECM. Heme-induced up-regulation STAT3 and CXCL10 promotes whereas HO-1 prevents brain tissue damage demonstrated involved induction apoptosis vascular endothelial cells. In present study, we further tested hypothesis reduces blood-brain barrier integrity ECM by cells through its target gene matrix metalloproteinase three (MMP3) signaling.Genes...