A5023744379- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Cancer-related cognitive impairment studies
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Cleft Lip and Palate Research
- Neuroscience and Neuropharmacology Research
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Infant Health and Development
- Craniofacial Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Neural and Behavioral Psychology Studies
- Glioma Diagnosis and Treatment
- Cancer survivorship and care
- Muscle Physiology and Disorders
- Functional Brain Connectivity Studies
- Advanced Neural Network Applications
- Epigenetics and DNA Methylation
- Muscle activation and electromyography studies
- Bipolar Disorder and Treatment
- Diet and metabolism studies
Arkansas Children's Hospital
2023-2025
University of Arkansas for Medical Sciences
2023-2025
University of Iowa
2008-2024
University of Iowa Hospitals and Clinics
2010-2024
University of Glasgow
2020-2021
Hudson Institute
2020
John Wiley & Sons (United States)
2020
Queen Elizabeth University Hospital
2020
Flemish Institute for Technological Research
2016-2018
Hospital for Sick Children
2013-2017
Substance dependence is associated with executive function deficits, but the nature of these defects and effect that different drugs sex have on not been fully clarified. Therefore, we compared performance alcohol- (n = 33; 18 women), cocaine- 27; 14 methamphetamine-dependent individuals 38; 25 women) sex-matched healthy comparisons 36; 17 complex decision making as measured Iowa Gambling Task, working memory, cognitive flexibility, response inhibition. Cocaine- were impaired making, The...
Non-linear MHD simulations of edge localized modes (ELMs) show features in qualitative agreement with the experimental observations such as formation and speed filaments, radial profiles fine structure observed power deposition at divertor target. The density perturbation predominantly follows ballooning mode convection cells leading to filaments. temperature perturbation, due large parallel conduction, magnetic field perturbation. Simulations pellets injected H-mode pedestal that high...
Despite the assumed prevalence of risk-taking behavior in adolescence, laboratory evidence risk taking remains scarce, and individual variation poorly understood. Drawing from neuroscience studies, we tested whether reward orientation are influenced by perspective that adolescents take when making risky decisions. Perspective was manipulated cuing participants prior to each choice decision made for "self," or an "other" (the experimenter Experiment 1; a hypothetical peer 2). In 1, show...
Research into the neural underpinnings of fear and fear-related pathology has highlighted role amygdala. For instance, bilateral damage to amygdaloid complex is associated with decreased appreciation danger recognition in humans, whereas enlarged amygdala volume internalizing syndromes. It unknown whether fearfulness are related absence pathology. We examined correlation between normal morphology 116 healthy children adolescents (60 boys, 56 girls, age 7–17 years). Fearfulness was measured...
Importance Pediatric patients with chronic kidney disease (CKD) exhibit reduced cerebellum volume, which is associated neurocognitive deficits and a lower estimated glomerular filtration rate (eGFR), even before dialysis or transplantation. These differences have not been examined within the context of age-related brain changes during childhood to early adulthood. Objective To evaluate in neurodevelopmental CKD compared control participants investigate associations between regional...
Abstract Introduction Survival rates for children with acute lymphoblastic leukemia ( ALL ) approach 95%. At the same time, there is growing concern that chemotherapy causes alterations in brain development and cognitive abilities. We performed MRI measurements of white gray matter volume to explore how variation structure may be related abilities survivors healthy controls. Methods The sample included 24 male who had completed contemporary treatment 3–11 years prior, 21 age‐ sex‐matched...
The purpose was to examine associations between treatment and chronic health conditions with neurocognitive impairment survivors of acute lymphoblastic leukemia (ALL) treated chemotherapy only.This cross-sectional study included 1207 ALL (54.0% female; mean age 30.6 years) 2273 siblings (56.9% 47.6 years), who completed the Childhood Cancer Survivor Study Neurocognitive Questionnaire. Multivariable logistic regression compared prevalence by sex. Associations exposures (graded according...
Abstract Background Pediatric chronic kidney disease (CKD) patients are at risk for cognitive deficits with worsening progression. Limited, existing cross‐sectional studies suggest that may improve following transplantation. We sought to assess performance in relationship transplantation and kidney‐specific medical variables a sample of pediatric transplant who provided longitudinal observations. Methods A retrospective chart review was conducted completed pre‐ and/or post‐transplant...
Knowledge about cognitive late effects in survivors of childhood acute lymphoblastic leukemia (ALL) is largely based on standardized neuropsychological measures and parent reports. To examine whether neuroscience paradigms provided additional insights into neurocognitive behavioral ALL survivors, we assessed cognition behavior using a selection tasks probing domains previously demonstrated to be affected by chemotherapy. 130 158 control subjects, between 8 18 years old at time testing,...
Myotonic dystrophy type 1 is the most common form of muscular in adults, and primarily characterized by muscle weakness myotonia, yet some disabling symptoms disease are cognitive behavioral. Here we evaluated several these non-motor from a cross-sectional time-point one largest longitudinal studies to date, including full-scale intelligence quotient, depression, anxiety, apathy, sleep, cerebral white matter fractional anisotropy group 39 adult-onset myotonic participants (27 female)...
Abstract Background Juvenile‐onset Huntington's disease (JOHD) is a rare and particularly devastating form of (HD) for which clinical diagnosis challenging robust outcome measures are lacking. Neurofilament light protein (NfL) in plasma has emerged as prognostic biomarker adult‐onset HD. Methods We performed retrospective analysis samples data collected between 2009 2020 from the Kids‐HD Kids‐JHD studies. Plasma children young adults with JOHD, premanifest HD (preHD) mutation carriers,...
Abstract Background Automated segmentation of individual calf muscle compartments in 3D MR images is gaining importance diagnosing disease, monitoring its progression, and prediction the disease course. Although deep convolutional neural networks have ushered a revolution medical image segmentation, achieving clinically acceptable results challenging task availability sufficiently large annotated datasets still limits their applicability. Purpose In this paper, we present novel approach...
Objectives/Goals: To assess the feasibility, safety, and preliminary efficacy of implementing a supervised, outpatient aerobic strength exercise regimen in newly diagnosed pediatric patients with acute lymphoblastic leukemia (ALL). We hypothesize that early implementation is feasible may prevent well-known cardiometabolic late effects. Methods/Study Population: will enroll 10–20 children (both males females) ALL between ages 11–21 years to participate 12-month structured (STRONGER ALL). This...
Breast cancer chemotherapy patients and survivors face cognitive side effects that are not fully understood. Neuroimaging can provide a unique way to study these effects; however, it be difficult recruit large numbers of subjects. Our meta-analysis aims synthesize volumetric neuroimaging data highlight consistent findings in regional brain volume changes further advance our understanding the chemotherapy-related impairments faced by breast survivors. An Activation Likelihood Estimation...
The prevalence of respiratory allergy in children is increasing. Epigenetic DNA methylation changes are plausible underlying molecular mechanisms. Saliva samples collected substudies two longitudinal birth cohorts Belgium (FLEHS1 & FLEHS2) were used to discover and confirm signatures that can differentiate individuals with from healthy subjects. Genome-wide analysis Illumina Methylation 450K BeadChips revealed 23 differentially methylated gene regions (DMRs) saliva 11y old allergic (N=26)...
Background: Few adequately-powered studies have systematically evaluated brain morphology in adult-onset myotonic dystrophy type 1 (DM1).Objective: The goal of the present study was to determine structural differences between individuals with and without DM1 a multi-site, case-controlled cohort.We also explored correlations structure CTG repeat length.Methods: Neuroimaging data acquired 58 unaffected (29 women) 79 (50 women).CTG length, expressed as estimated progenitor allele length (ePAL),...