Timothy Van Meter
A5005718784- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- MicroRNA in disease regulation
- Chromatin Remodeling and Cancer
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Cardiac Arrest and Resuscitation
- Genomics and Chromatin Dynamics
- Protein Degradation and Inhibitors
- Cell Adhesion Molecules Research
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Trauma and Emergency Care Studies
- S100 Proteins and Annexins
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
Johns Hopkins University
2013-2024
University of Michigan
2017-2024
Pennsylvania State University
2024
Neurology, Inc
2009-2023
Virginia Commonwealth University
2012-2022
Georgetown University
2022
Johns Hopkins Medicine
2013-2019
Children's Hospital of Richmond at VCU
2007-2018
Baylor College of Medicine
2017
University of Pennsylvania
2017
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1,087 unique...
Abstract Ataxia telangiectasia (A-T) mutated (ATM) is critical for cell cycle checkpoints and DNA repair. Thus, specific small molecule inhibitors targeting ATM could perhaps be developed into efficient radiosensitizers. Recently, a inhibitor of the kinase, KU-55933, was shown to radiosensitize human cancer cells. Herein, we report on an improved analogue KU-55933 (KU-60019) with Ki IC50 values half those KU-55933. KU-60019 10-fold more effective than at blocking radiation-induced...
Abstract Medulloblastoma is the most common malignant pediatric brain tumor, and mechanisms underlying its development are poorly understood. We identified recurrent amplification of miR-17/92 polycistron proto-oncogene in 6% medulloblastomas by high-resolution single-nucleotide polymorphism genotyping arrays subsequent interphase fluorescence situ hybridization on a human medulloblastoma tissue microarray. Profiling expression 427 mature microRNAs (miRNA) series 90 primary revealed that...
Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT medulloblastoma have not been described. Hence, we sought describe these their impact a subgroup-specific manner. We analyzed by direct sequencing genotyping 466 medulloblastomas. The mutational distributions determined according subgroup affiliation, demographics, clinical,...
Amplification of the C19MC oncogenic miRNA cluster and high LIN28 expression has been linked to a distinctly aggressive group cerebral CNS-PNETs (group 1 CNS-PNETs) arising in young children. In this study, we sought evaluate diagnostic specificity LIN28, clinical biological spectra amplified and/or LIN28+ CNS-PNETs. We interrogated 450 pediatric brain tumors using FISH IHC analyses demonstrate that alteration is restricted sub-group with expression; however, immunopositivity was not...
Effective team science requires procedural harmonization for rigor and reproducibility. Multicenter studies across experimental modalities (domains) can help accelerate translation. The Translational Outcomes Project in NeuroTrauma (TOP-NT) is a pre-clinical traumatic brain injury (TBI) consortium charged with establishing validating noninvasive TBI assessment tools through science. Here, we present practical approaches of research five centers providing needed vocabulary structure to...
Abstract Medulloblastomas are the most frequent malignant brain tumors in children. Sunitinib is an oral multitargeted tyrosine kinase inhibitor used clinical trials as antiangiogenic agent for cancer therapy. In this report, we show that sunitinib induced apoptosis and inhibited cell proliferation of both a short-term primary culture (VC312) established line (Daoy) human medulloblastomas. treatment resulted activation caspase-3 cleavage poly(ADP-ribose) polymerase upregulation proapoptotic...
Medulloblastomas are the most frequent malignant brain tumors in children. Sorafenib (Nexavar, BAY43-9006), a multikinase inhibitor, blocks cell proliferation and induces apoptosis variety of tumor cells. inhibited induced two established lines (Daoy D283) primary culture (VC312) human medulloblastomas. In addition, sorafenib phosphorylation signal transducer activator transcription 3 (STAT3) both The inhibition phosphorylated STAT3 (Tyr(705)) occurs dose- time-dependent manner. contrast,...
Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown. We have identified rare, recurrent homozygous deletions of Kruppel-like Factor 4 (KLF4) in using high-resolution single nucleotide polymorphism arrays, digital karyotyping, and genomic real-time polymerase chain reaction (PCR). Furthermore, we show that there loss physiological KLF4 expression more than 40% primary medulloblastomas both at RNA protein levels....