Mathieu Lupien
A5004938979- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Circular RNAs in diseases
- Advanced Breast Cancer Therapies
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Glioma Diagnosis and Treatment
- Genetics, Bioinformatics, and Biomedical Research
- Renal and related cancers
- Acute Myeloid Leukemia Research
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Mechanisms of cancer metastasis
- CRISPR and Genetic Engineering
- Gene expression and cancer classification
- Hormonal Regulation and Hypertension
University of Toronto
2016-2025
Ontario Institute for Cancer Research
2016-2025
Princess Margaret Cancer Centre
2016-2025
University Health Network
2016-2025
Health Net
2012-2024
Vector Institute
2023
Duke University
2022
Institute of Cancer Research
2015-2021
Université de Sherbrooke
2015
Université Libre de Bruxelles
2015
DNA variants (SNPs) that predispose to common traits often localize within noncoding regulatory elements such as enhancers. Moreover, loci identified by genome-wide association studies (GWAS) contain multiple SNPs in linkage disequilibrium (LD), any of which may be causal. Thus, determining the effect these variant on target transcript levels has been a major challenge. Here, we provide evidence for six autoimmune disorders (rheumatoid arthritis, Crohn's disease, celiac sclerosis, lupus, and...
Abstract The transcription factor GATA-3 is required for normal mammary gland development, and its expression highly correlated with estrogen receptor α (ERα) in human breast tumors. However, the functional role of ERα-positive cancers yet to be established. Here, we show that estradiol stimulation cell cycle progression cancer cells. signaling requires direct positive regulation ERα gene itself by GATA-3. binds two cis-regulatory elements located within gene, this RNA polymerase II...
BackgroundThe majority of prostate cancers harbor gene fusions the 5′-untranslated region androgen-regulated transmembrane protease serine 2 (TMPRSS2) promoter with erythroblast transformation–specific transcription factor family members. The common fusion between TMPRESS2 and v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG) is associated a more aggressive clinical phenotype, implying existence distinct subclass cancer defined by this fusion.
Colorectal Cancer Signature The mutations and genome aberrations that characterize cancer result in often dramatically altered gene protein expression patterns. It is these patterns directly indirectly drive progression of the disease. In human primary colorectal cells, Akhtar-Zaidi et al. (p. 736 , published online 12 April) analyzed pattern epigenetically modified chromatin at “enhancer” sequences are known to be critical control expression. An epigenetic enhancer signature was defined...
Pharmacogenomics holds great promise for the development of biomarkers drug response and design new therapeutic options, which are key challenges in precision medicine. However, such data scattered lack standards efficient access analysis, consequently preventing realization full potential pharmacogenomics. To address these issues, we implemented PharmacoGx, an easy-to-use, open source package integrative analysis multiple pharmacogenomic datasets. We demonstrate utility our comparing large...
Despite much evidence on epigenetic abnormalities in cancer, it is currently unclear to what extent alterations can be associated with tumors' clonal genetic origins. Here, we show that the prostate intratumor heterogeneity DNA methylation and copy-number patterns explained by a unified evolutionary process. By assaying multiple topographically distinct tumor sites, premalignant lesions, lymph node metastases within five cases of demonstrate both consistently reflect life history tumors....
Abstract Triple negative breast cancer (TNBC) is a deadly form of due to the development resistance chemotherapy affecting over 30% patients. New therapeutics and companion biomarkers are urgently needed. Recognizing elevated expression glucose transporter 1 (GLUT1, encoded by SLC2A1 ) associated metabolic dependencies in TNBC, we investigated vulnerability TNBC cell lines patient-derived samples GLUT1 inhibition. We report that genetic or pharmacological inhibition with BAY-876 impairs...
Chromatin interactions connect distal regulatory elements to target gene promoters guiding stimulus- and lineage-specific transcription. Few factors securing chromatin have so far been identified. Here, by integrating interaction maps with the large collection of transcription factor-binding profiles provided ENCODE project, we demonstrate that zinc-finger protein ZNF143 preferentially occupies anchors connecting elements. It binds directly associates expression. Silencing or modulating its...