A5058192036- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Barrier Structure and Function Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetic factors in colorectal cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Glycosylation and Glycoproteins Research
- S100 Proteins and Annexins
- Anesthesia and Neurotoxicity Research
- Infant Nutrition and Health
- Mitochondrial Function and Pathology
- Carbohydrate Chemistry and Synthesis
- Pain Mechanisms and Treatments
- Bone fractures and treatments
- Digestive system and related health
- Urinary Tract Infections Management
- Epigenetics and DNA Methylation
- Reproductive tract infections research
- Enzyme Production and Characterization
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Clusterin in disease pathology
- Ion Channels and Receptors
Shandong University
2015-2025
Shandong Maternal and Child Health Hospital
2021-2025
Shandong First Medical University
2021-2025
Women & Infants Hospital of Rhode Island
2016-2025
Brown University
2016-2025
Shenyang Medical College
2023-2025
Shenzhen Children's Hospital
2022-2024
Shanghai University
2022-2024
Karolinska Institutet
2024
Nationwide Children's Hospital
2024
Abstract Background The expression of carcino-embryonic antigen by colorectal cancer is an example oncogenic activation embryonic gene expression. Hypothesizing that oncogenesis-recapitulating-ontogenesis may represent a broad programmatic commitment, we compared patterns human cancers (CRCs) and mouse colon tumor models to those development days 13.5-18.5. Results We report here 39 tumors from four independent 100 CRCs encompassing all clinical stages shared striking recapitulation Compared...
Impaired blood-brain barrier function represents an important component of hypoxic-ischemic brain injury in the perinatal period. Proinflammatory cytokines could contribute to ischemia-related dysfunction. IL-6 increases vascular endothelial cell monolayer permeability vitro. However, contributions abnormalities have not been examined immature vivo. We generated pharmacologic quantities ovine-specific neutralizing anti-IL-6 mAbs and systemically infused into fetal sheep at 126 days gestation...
Early detection of colorectal cancer is critical for the management this disease. Biomarkers early several cancers have been developed and applied clinically in recent years. We sought to discover candidate biomarkers without restricted choice markers placed on microarrays, biological complications genetic environmental heterogeneity. compared by cDNA subtraction two genetically matched sets mice, one developing multiple intestinal neoplasia (C57BL/6J- Apc Min ) other tumor-free (C57BL/6J)....
<b><i>Objectives:</i></b> The blood-brain barrier is a selective diffusion between brain parenchyma and the intravascular compartment. Tight junctions are integral components of barrier. Pro-inflammatory cytokines important in pathogenesis injury could modify protein constituents tight junctions. We hypothesized that interleukin-6 (IL-6) downregulates key endothelial (e.g. occludin claudin-5). <b><i>Methods:</i></b> examined effects IL-6 on...
Recent studies have elucidated the role of lysine-specific demethylase 1 (LSD1), a member histone demethylases, in epigenetic regulation tumor suppressing/promoting genes and neoplastic growth. However, expression LSD1 patients with esophageal squamous cell carcinoma (ESCC) is still unknown. Here, we reported that was elevated cancerous tissue correlated lymph node metastasis poorer overall survival ESCC. Compared to EC109 cells, unregulated aggressive cancer lines KYSE450 KYSE150. Knockdown...
α-L-Fucosidases are attractive biocatalysts for the production of bioactive fucosylated oligosaccharides, however, poor regioselectivity and activity transglycosylation have significantly limited their applications. We recently derived an α-L-Fucosidase, BF3242, from Bacteroides fragilis NCTC9343, which could efficiently synthesize a mixture Fuc-α-1,3/1,6-GlcNAc, but its 1,3/1,6-regioselectivity was observably affected by reaction temperature. Here, we integrated loop-targeted random...
Exposure to fine particulate matter (PM2.5) is a significant risk factor for asthma, promoting airway inflammation and oxidative stress. This study evaluates Nobiletin's (NOB) efficacy in mitigating lung damage asthma-induced mice exposed PM2.5. Using an ovalbumin (OVA) plus PM2.5-induced asthma model BALB/c mice, we investigated the therapeutic impacts of NOB compared dexamethasone (DEX). significantly moderated index values inflammatory markers without affecting body weight. Notably,...
Cisplatin resistance is a major obstacle in the treatment of NSCLC, and its mechanism has not been fully elucidated. The objectives study were to determine role miR-378 sensitivity lung adenocarcinoma cells cisplatin (cDDP) working mechanism. With TargetScan luciferase assay, was found directly target sCLU. sCLU regulated A549/cDDP Anip973/cDDP investigate effect on apoptotic effects cDDP. upregulation tumor growth analyzed nude mouse xenograft model. correlation between chemoresistance...
Pro-inflammatory cytokines contribute to hypoxic-ischemic brain injury. Blood-brain barrier (BBB) dysfunction represents an important component of injury in the fetus. Hypoxic-ischemic could accentuate systemic cytokine transfer across fetal BBB. There has been considerable conjecture suggesting that cross BBB during perinatal period. Nonetheless, evidence support this contention is sparse. We hypothesized ischemia-reperfusion increases interleukin-1β (IL-1β) Ovine fetuses at 127 days...
β-N-Acetylhexosaminidases have attracted interest particularly for oligosaccharide synthesis, but their use remains limited by the rarity of enzyme sources , low efficiency, and relaxed regioselectivity transglycosylation. In this work, genes 13 β-N-acetylhexosaminidases, including 5 from Bacteroides fragilis ATCC 25285, Clostridium perfringens 13124, 3 Bifidobacterium bifidum JCM 1254, were cloned heterogeneously expressed in Escherichia coli The resulting recombinant enzymes purified...
The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the subfamily is comprised multiple members, including eight in humans. However, Drosophila unusual that it consists a single member. Currently, functional requirements for this channel have not been reported. Here, we found protein was expressed fly counterpart mammalian kidneys, Malpighian tubules, which function removal electrolytes and toxic components...
ABSTRACT Gut bacteria provide a rich source of glycosidases that can recognize and/or hydrolyze glycans for nutrition. Interestingly, some have also been found to catalyze transglycosylation reactions in vitro and thus be used oligosaccharide synthesis. In this work, six putative one known exo -α-sialidase genes—three from Bacteroides fragilis NCTC9343, three Clostridium perfringens ATCC 13124, Bifidobacterium bifidum JCM1254—were subjected gene cloning heterogeneous expression Escherichia...