A5008360619- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
- Supramolecular Self-Assembly in Materials
- Nerve injury and regeneration
- Hair Growth and Disorders
- Erythrocyte Function and Pathophysiology
- Ion channel regulation and function
- Mass Spectrometry Techniques and Applications
- Axon Guidance and Neuronal Signaling
- melanin and skin pigmentation
- Neurobiology and Insect Physiology Research
- Retinal Diseases and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Lipid metabolism and biosynthesis
- Cellular Mechanics and Interactions
- Ion Channels and Receptors
- Cancer Cells and Metastasis
Sichuan Normal University
2022-2025
Sun Yat-sen University Cancer Center
2025
Sun Yat-sen University
2025
City University of New York
2018-2024
The Graduate Center, CUNY
2018-2024
CUNY Advanced Science Research Center
2019-2024
National Institute of Neurological Disorders and Stroke
2024
Southern Medical University
2021-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Abstract Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric diseases including depression and anxiety disorders. Here we show that, a rodent model induced by chronic restraint stress (CRS), dysregulation occurs basolateral projection neurons receiving mono-directional inputs from dorsomedial cortex (dmPFC→BLA PNs) rather than those reciprocally connected with dmPFC (dmPFC↔BLA PNs). Specifically, CRS shifts dmPFC-driven excitatory-inhibitory balance...
Abstract Background Breast cancer is the most prevalent among women worldwide. WZ35, an analog of curcumin, has been demonstrated to remarkably improve pharmacokinetic profiles in vivo compared with curcumin. WZ35 exhibits promising antitumor activity gastric cancer, HCC, colon cancer. However, effects breast and its underlying molecular mechanisms remain unclear. Methods CCK8, Flow cytometry transwell assays were used measure cell proliferation, cycle arrest, apoptosis, migration invasion....
Androgenic alopecia (AGA), also known as male pattern baldness, is one of the most common hair loss diseases worldwide. The main treatments AGA include transplant surgery, oral medicines, and LDL laser irradiation, although no treatment to date can fully cure this disease. Animal models play important roles in exploration potential mechanisms disease development assessing novel treatments. present study describes androgen receptor (AR) C57BL/6 mouse follicles that be activated by...
Supramolecular self-assembly of fibrous components and liquid–liquid phase separation are at the extremes order-to-disorder spectrum. They collectively play key roles in cellular organization. It is still a major challenge to design systems where both highly ordered nanostructures phase-separated domains can coexist. We present three-component assembly approach that generates exclusively form inside globally disordered, liquid condensates. This achieved by creating amphiphilic peptides...
Dysregulated lipid homeostasis is emerging as a potential cause of neurodegenerative disorders. However, evidence errors in pathogenic mechanism neurodegeneration remains limited. Here, we show that cerebellar caused by Sorting Nexin 14 (SNX14) deficiency associated with defects. Recent studies indicate SNX14 an inter-organelle transfer protein regulates transport, droplet (LD) biogenesis, and fatty acid desaturation, suggesting human belongs to expanding class disorders altered cellular...
Chronic stress is generally known to exacerbate the development of numerous neuropsychiatric diseases such as fear and anxiety disorders, which at least partially due disinhibition amygdala subsequent prolonged exposure. GABA receptor A (GABAAR) mediates primary component inhibition in brain its activation produces two forms inhibition: phasic tonic inhibition. While both them are critically engaged limiting activity amygdala, their roles chronic exposure largely unknown. We investigated...
Medulloblastoma (MB) is the most common pediatric CNS malignancy. We identify EAG2 as an overexpressed potassium channel in MBs across different molecular and histological subgroups. knockdown not only impairs MB cell growth vitro, but also reduces tumor burden vivo enhances survival xenograft studies. Mechanistically, we demonstrate that protein confined intracellularly during interphase enriched plasma membrane late G2 phase mitosis. Disruption of expression results arrest mitotic...
ABSTRACT Bisphenol A (BPA), one of the most common environmental endocrine disruptors, has been recognized to have wide adverse effects on brain development and behavior. These adversities are related its ability bind estrogen receptor (ER) with subsequent alteration expression in target areas. However, very little is known about whether BPA exposure also affects ER phosphorylation translocation nucleus during postnatal development, two critical steps for function. Here, we found that from...
Abstract Lipid shuttling between neurons and glia contributes to the development, function, stress responses of nervous system. To understand how a neuron acquires its lipid supply from specific lipoproteins their receptors, we perform combined genetic, transcriptome, biochemical analyses in developing Drosophila larval brain. Here report, astrocyte-derived secreted lipocalin Glial Lazarillo (GLaz), homolog human Apolipoprotein D (APOD), neuronal receptor, brain-specific short isoforms...
Supramolecular self-assembly in biological systems holds promise to convert and amplify disease-specific signals physical or mechanical that can direct cell fate. However, it remains challenging design physiologically stable self-assembling demonstrate tunable predictable behavior. Here, the use of zwitterionic tetrapeptide modalities nanoparticle assembly under physiological conditions is reported. The gold nanoparticles be activated by enzymatic unveiling surface-bound tetrapeptides...