A5012327060- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Estrogen and related hormone effects
- Heavy metals in environment
- Bioactive natural compounds
- Advanced Nanomaterials in Catalysis
- Sirtuins and Resveratrol in Medicine
- Nitric Oxide and Endothelin Effects
- MicroRNA in disease regulation
- Connexins and lens biology
- Bone Tissue Engineering Materials
- Epigenetics and DNA Methylation
- Inflammatory mediators and NSAID effects
- Musculoskeletal pain and rehabilitation
- Histone Deacetylase Inhibitors Research
- Nicotinic Acetylcholine Receptors Study
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Osteoarthritis Treatment and Mechanisms
- Mine drainage and remediation techniques
- Cancer Cells and Metastasis
- Ergonomics and Musculoskeletal Disorders
- Garlic and Onion Studies
Nanchang University
2011-2025
Gannan Medical University
2021-2025
Guangdong University of Technology
2022-2025
Southern Medical University
2022-2025
State Key Laboratory of Respiratory Disease
2023-2024
Guangzhou Medical University
2023-2024
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University
2024
Stomatology Hospital
2023
Jiangxi Provincial Academy of Medical Sciences
2016-2022
Recent advances in bioprinting have granted tissue engineers the ability to assemble biomaterials, cells, and signaling molecules into anatomically relevant functional tissues or organ parts. Scaffold-free fabrication has recently attracted a great deal of interest due recapitulate biology by using self-assembly, which mimics embryonic development process. Despite several attempts, scale-up at clinically-relevant dimensions with closely recapitulated functionality is still major roadblock....
Chronic stress is generally known to exacerbate the development of numerous neuropsychiatric diseases such as fear and anxiety disorders, which at least partially due disinhibition amygdala subsequent prolonged exposure. GABA receptor A (GABAAR) mediates primary component inhibition in brain its activation produces two forms inhibition: phasic tonic inhibition. While both them are critically engaged limiting activity amygdala, their roles chronic exposure largely unknown. We investigated...
Abstract Metastasis remains the principal cause of cancer-related lethality despite advancements in cancer treatment. Dysfunctional epigenetic alterations are crucial metastatic cascade. Among these, super-enhancers (SEs), emerging as new regulators, consist large clusters regulatory elements that drive high-level expression genes essential for oncogenic process, upon which cells develop a profound dependency. These SE-driven oncogenes play an important role regulating various facets...
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), induce high morbidity mortality rates, which challenge the present approaches for treatment of ALI/ARDS. The clinically used photosensitizer verteporfin (VER) exhibits great potential in (ALI/ARDS) by regulating macrophage polarization reducing inflammation. Nevertheless, hydrophobic characteristics, nonspecificity, constrained bioavailability hinder therapeutic efficacy. In this work, we developed a...
ABSTRACT Bisphenol A (BPA), one of the most common environmental endocrine disruptors, has been recognized to have wide adverse effects on brain development and behavior. These adversities are related its ability bind estrogen receptor (ER) with subsequent alteration expression in target areas. However, very little is known about whether BPA exposure also affects ER phosphorylation translocation nucleus during postnatal development, two critical steps for function. Here, we found that from...
Histone deacetylase 3 (HDAC3) is a well-established target for cancer therapy. Herein, we developed LSQ-28 as novel HDAC3 inhibitor, which exhibited high inhibitory activity (IC50 = 42 nM, SI > 161) and displayed potent antiproliferative against four cells further demonstrated excellent antimigratory, anti-invasive, antiwound healing activities. Further studies revealed that induced dose-dependent increase in Ac-H3 expression promoted the degradation of PD-L1. Additionally, enhanced DNA...
Background/Objectives: Diabetes mellitus is often accompanied by mental health complications, including anxiety, depression, and cognitive decline. Recent research suggested that capsaicin, the active component of chili peppers, may influence health. This study aimed to determine effect dietary capsaicin on disorders in a type 1 diabetes (T1D) mouse model, while also exploring potential involvement microbiota-gut-brain axis. Methods: We induced T1D mice using streptozotocin (STZ)...
This paper analyzed the causes of peripheral nerve injury induced by acupoint injection, and proposed methods for prevention. These included emphasizing physicochemical properties medications strengthening research on medication compatibility, classifying high-risk acupoints establishing international standards safe needling, standardizing clinical procedures incorporating ultrasound technology when necessary to improve accuracy safety procedure. strategies aimed reduce risk associated with...