A5101612454- Geological and Geochemical Analysis
- earthquake and tectonic studies
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
- High-pressure geophysics and materials
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Cloud Computing and Resource Management
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Geochemistry and Geologic Mapping
- IoT and Edge/Fog Computing
- Esophageal Cancer Research and Treatment
- Glutathione Transferases and Polymorphisms
- Studies on Chitinases and Chitosanases
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Gastric Cancer Management and Outcomes
- PI3K/AKT/mTOR signaling in cancer
- RNA and protein synthesis mechanisms
- Geology and Paleoclimatology Research
- Advanced Nanomaterials in Catalysis
- Inflammatory Biomarkers in Disease Prognosis
Hebei University of Chinese Medicine
2024
State Key Laboratory of Respiratory Disease
2022-2024
Guangzhou Medical University
2022-2024
First Affiliated Hospital of Xi'an Jiaotong University
2012-2024
Tongji University
2015-2024
First Affiliated Hospital of Guangzhou Medical University
2024
Wenzhou Medical University
2012-2024
Taizhou First People's Hospital
2017-2023
Daping Hospital
2023
Guangzhou University
2018-2023
Nuclear factor E2-related 2 (Nrf2 or NFE2L2) is abundantly expressed in cancer cells and relates to proliferation, invasion, chemoresistance. Our early observations also found that expression of Nrf2 was up-regulated kinds including human hepatocellular carcinoma (HCC) cells. But there are limited reports about the expression, significance, function HCC. First, analyzed HCC cell lines tumor samples. Then, relationship with clinicopathological factors survival were analyzed. Further, effect...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology affecting the colon and rectum. Current therapeutics are focused on suppressing inflammation but ineffective. Combining anti-inflammatory therapeutic approaches with pro-resolution might be superior strategy for UC treatment. Andrographolide (AG), an active compound from plant Andrographis paniculata, presented effects in various diseases. Gaseous mediators, such as carbon monoxide (CO), have role resolution....
Propofol is one of the most commonly used intravenous anaesthetic agents during cancer resection surgery, but effect propofol on gallbladder not clear. NF-E2-related factor 2 (Nrf2) abundantly expressed in cells and relates to proliferation, invasion, chemoresistance. The aims current study were evaluate effects behavior human GC role Nrf2 these effects.The cell apoptosis, invasion detected by MTT assays, flow cytometry, transwell assay. Also, activation was determined western blot, RT-PCR,...
MicroRNAs (miRNAs) represent a class of small non‐coding RNAs that regulate gene expression at the post‐transcriptional levels. Recent studies show miRNAs may function as oncogenes or tumor suppressor genes. In this study, we demonstrated miR‐518b was down‐regulated in esophageal squamous cell carcinoma (ESCC) tissues and correlated with metastasis survival. suppressed proliferation by inducing apoptosis repressed invasion ESCC cells, but had no effect on cycle. Furthermore, Rap1b revealed...
ErbB4 expression has been noted in various tumors, but its regulatory mechanism esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of this study was to investigate whether miR-302b regulates the at post-transcriptional level and determine expression, significance, function ESCC. We used real-time reverse transcriptase-polymerase chain reaction quantify 50 ESCC tissues analyzed relationship with clinicopathological factors survival. Then, we investigated regulation using...
Abstract This manuscript aimed to investigate linc‐PINT's role as a tumor suppressor and its downstream microRNAs (miRNAs) in esophageal cancer. Log‐rank, Cox, nomogram were used for survival analysis. Quantitative real‐time polymerase chain reaction was evaluate the expression. Cell counting kit‐8 proliferation tests. As vivo experiments, low expression of linc‐PINT associated with better prognosis; besides, indicated that linc‐PINT, miR‐543, miR‐576‐5p served well predicting rate. vitro...
Introduction Enhancing human papillomavirus (HPV) vaccine uptake rates to protect women's health is an important public issue worldwide. China has taken a series of measures in recent years promote HPV vaccination among school-aged girls, but the rate remains low. Investigating factors influencing vaccination-related decision-making adolescent girls' parents key solving problem. This study aimed examine influence sociocultural-psychological predictors, including exposure HPV-related stories...
The balance of M1/M2 macrophage polarization plays an important role in regulating inflammation during acute lung injury (ALI). Yes-associated protein (YAP1) is a key the Hippo-YAP1 signaling pathway and involved polarization. We aimed to determine YAP1 pulmonary following ALI regulation Pulmonary with upregulation were observed lipopolysaccharide (LPS)-induced ALI. inhibitor, verteporfin, attenuated improved function mice. Moreover, verteporfin promoted M2 inhibited M1 tissues mice...
The replacement of rutile by Fe-Ti oxides is a common phenomenon during the retrogression eclogites. Here, we report an unusual case regarding greenschist-facies metamorphic overprinting veins in amphibolites (retrograded eclogites) from Dabie ultrahigh-pressure (UHP) terrane, eastern China. mainly consist plagioclase, oxides, and quartz, which crystallized Ti-rich amphibolite-facies fluid that formed exhumation Two types textures involving are recognized veins: (1) first type characterized...
Cancer related inflammation (CRI) plays an important role in the development of esophageal cancer (EC), and target gene analysis shows that miR-302b potential genes closely correlated to CRI signaling pathways. The present study was evaluate inhibition on EC its mechanism. We found expression levels cells were lower than Het-1A cells, while TE11 with lowest OE33 highest. Inflammatory stimuli at 48 h significantly reduced but had no effect Het-1A. After up-regulation down-regulation OE33, it...
Abstract The existence of ancient rocks in present mid-ocean ridges have long been observed but received less attention. Here we report the discovery zircons with both reasonably young ages about 5 Ma and abnormally old approximate 180 from two evolved gabbroic that were dredged Southwest Indian Ridge (SWIR) Gallieni fracture zone. U–Pb Lu–Hf isotope analyses made using ion probe conventional laser abrasion directly petrographic thin sections. Young their host oxide gabbro positive Hf...
To guide clinicians in selecting treatment options for patients with non-small cell lung cancer (NSCLC), it is desirable to have reliable markers predicting clinical outcome. This study analyzed the correlation between signal transducer and activator of transcription 3 (STAT3) cyclin D1 NSCLC their association clinicopathological features survival.We investigated 65 specimens tissues by immunohistochemistry using STAT3 antibodies. First we determined expression tumor. Then assessed...