A5101598897- Cancer-related molecular mechanisms research
- Orthopaedic implants and arthroplasty
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Total Knee Arthroplasty Outcomes
- Bone Tissue Engineering Materials
- Heart Failure Treatment and Management
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Orthopedic Infections and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Bone fractures and treatments
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Cancer Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Virus-based gene therapy research
- Dental Implant Techniques and Outcomes
- Spectroscopy Techniques in Biomedical and Chemical Research
- Radiomics and Machine Learning in Medical Imaging
- Sphingolipid Metabolism and Signaling
- Cancer-related gene regulation
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Shenzhen Children's Hospital
2025
China Medical University
2025
Karolinska Institutet
2024
Shaanxi University of Chinese Medicine
2024
East China Normal University
2018-2024
Nanjing General Hospital of Nanjing Military Command
2023
Hangzhou Xixi hospital
2017-2023
Chengdu Fifth People's Hospital
2023
Chengdu University of Traditional Chinese Medicine
2023
A previous study identified MoRgs1 as an RGS protein that negative regulates G-protein signaling to control developmental processes such conidiation and appressorium formation in Magnaporthe oryzae. Here, we characterized additional seven RGS-like proteins (MoRgs2 through MoRgs8). We found MoRgs4 positively regulate surface hydrophobicity, conidiation, mating. Indifference MoRgs1, has a role regulating laccase peroxidase activities. MoRgs2, MoRgs3, MoRgs4, MoRgs6, MoRgs7 are important for...
MicroRNAs play crucial roles in plant responses to pathogen infections. The rice blast disease, caused by the fungus Magnaporthe oryzae, is most important disease of (Oryza sativa). To explore microRNA species that participate immunity against we compared expression small RNAs between mock- and M. oryzae-treated rice. We found infection oryzae strain Guy11 specifically induced miR319 and, consequently, suppressed its target gene TEOSINTE BRANCHED/CYCLOIDEA/PROLIFERATING CELL FACTOR1...
Tumor-associated macrophages (TAMs) are associated with poor prognosis in numerous human cancers and play important roles tumor progression. Epithelial-mesenchymal transition (EMT) contributes to invasion metastasis cancer. However, the associations between TAMs EMT not clear gastric cancer (GC). The present study was designed investigate effects of on GC.TAMs marker CD68 EMT-related proteins were detected by immunohistochemistry (IHC) GC tissues their clinical significance evaluated.A high...
Abstract Oxaliplatin resistance undermines its curative effects on cancer and usually leads to local recurrence. The oxidative stress induced DNA damage repair response is an important mechanism for inducing oxaliplatin by activating autophagy. ELISA used detect target genes expression. TMT-based quantitative proteomic analysis was investigate the potential mechanisms involved in NORAD interactions based GO analysis. Transwell assays apoptosis flow cytometry were biological function CCK-8...
Cyclic AMP (cAMP) signaling plays an important role in regulating multiple cellular responses, such as growth, morphogenesis, and/or pathogenicity of eukaryotic organisms fungi. As a second messenger, cAMP is the activation downstream effector molecules. The balance intracellular levels depends on biosynthesis by adenylyl cyclases (ACs) and hydrolysis phosphodiesterases (PDEases). rice blast fungus Magnaporthe oryzae contains high-affinity (PdeH/Pde2) low-affinity (PdeL/Pde1) PDEases,...
Maternal famine exposure has been associated with higher blood pressure in the offspring. The aim of present study was to examine associations early life 1959-1961 Chinese risk hypertension later life, and whether a nutritional 'rich' environment modifies this association.We used data 7874 adults born between 1954 1964 from 2002 China National Nutrition Health Survey. Excess death rate determine severity famine.In severely affected areas, as compared who were not exposed famine, those during...
Geraniol is a type of monoterpenoid with rose scent and slightly sweet flavor. It found in the volatile oil various plants, has anti-inflammatory anti-oxidant effects. The present study aimed to investigate protective effect geraniol inhibiting inflammatory response, oxidative stress apoptosis traumatic spinal cord injury (SCI), as well analyze mechanism underlying its effect. Adult male Sprague-Dawley rats were induced SCI through surgical procedure defined model group. or normal then...
Background: Recent studies show that epithelial–mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) contribute to the progression poor prognosis of carcinoma through multiple mechanisms. Both inflammation changing epithelium have a close relationship with tumorigenesis gastric cancer. However, relevance between EMT TAMs is still unclear in cancer needs more scientific research. This study designed explore Materials methods: Immunohistochemistry was used detect expression...
Gastric cancer incidence is relatively higher in China than that developed countries; however, molecular mechanisms considering the initiation and progression of gastric are still unclear. For decades, numerous microRNAs have been found to regulate a wide range biological functions cancer. However, oncogenic function miR-615-3p has not reported date. With help gene microRNA chips 10 patients, we were able screen differential expressed genes compared with normal tissues. After that, online...
Abstract MicroRNAs plays an important role in the ccurrence and development of non–small‐cell lung cancer (NSCLC). miR‐497‐5p has been reported to function as a tumor suppressor various cancers. However, NSCLC remains poorly understood. In this study, we aimed investigate biological potential molecular mechanism NSCLC. Our results showed that messenger RNA (mRNA) expression level was notably downregulated human tissues cell lines. overexpression remarkably inhibited proliferation increased...
High-dose aprotinin appears to enhance the anticoagulant effects of heparin, as documented by increases in activated clotting times (ACTs) during cardiopulmonary bypass; hence, some authorities have advocated reducing dose heparin patients treated with aprotinin. An vitro study our group suggested that increase ACT presence and may be due use celite surface activator. We compared kaolin activators for measurement cardiac surgical given no This double-blind, randomized, placebo-controlled...
Several studies conducted during the 1990s indicated that childhood allergic diseases were increasing worldwide, but more recent investigations in some Western countries have suggested trend is stabilizing or may even be reversing. However, few data are available on current status of disease prevalence Chinese children. The aim present study was to investigate rates asthma, rhinitis, and eczema children three major cities China, determine among generally, evaluate different ages. We a...
MicroRNAs (miRNAs) represent a class of small non‐coding RNAs that regulate gene expression at the post‐transcriptional levels. Recent studies show miRNAs may function as oncogenes or tumor suppressor genes. In this study, we demonstrated miR‐518b was down‐regulated in esophageal squamous cell carcinoma (ESCC) tissues and correlated with metastasis survival. suppressed proliferation by inducing apoptosis repressed invasion ESCC cells, but had no effect on cycle. Furthermore, Rap1b revealed...
Abstract BACKGROUND: Studies have shown that superior mesenteric vein (SMV)/portal (PV) resection with pancreaticoduodenectomy (PD) is safe and feasible for patient pancreatic adenocarcinoma (PAC). However, the prognostic significance of tumor involvement resected in patients who received neoadjuvant therapy unclear. METHODS: The authors evaluated 225 consecutive stage II PAC PD or without SMV/PV resection. was entirely submitted histologic assessment reviewed all cases. Tumor correlated...
Palacos R bone cement was mixed in a commercial vacuum mixing system (MITAB), and an experimental allowing evacuating air from the powder before collecting under partial vacuum. The effect on porosity of at different pressure levels tested. also analyzed. numbers sizes voids samples were measured radiographs microscope. Also, density measured. Vacuum had substantial reduction voids, as well increase compared to atmospheric pressure. After collection, further increased seen; all large within...
Abstract Background The aim of the present study was to explore therapeutic effect and prognosis in patients with rib fractures atelectasis after thoracic trauma order provide a basis for clinical decision-making primary hospitals. Methods A retrospective conducted on 86 admitted our hospital between January 2016 May 2020 trauma. On chest computed tomography scans taken at time discharge, were divided into two groups: reexpansion group non-reexpansion group. groups compared respect changes...