A5101790944- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Flood Risk Assessment and Management
- Mesenchymal stem cell research
- Nanoparticle-Based Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Urban Heat Island Mitigation
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Inflammatory Bowel Disease
- Virus-based gene therapy research
- Chromosomal and Genetic Variations
- Glioma Diagnosis and Treatment
- Urban Stormwater Management Solutions
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
- Tropical and Extratropical Cyclones Research
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury Research
- IL-33, ST2, and ILC Pathways
- Galectins and Cancer Biology
University of California, Davis
2021-2025
Sun Yat-sen University
2025
Inner Mongolia University
2025
Shanghai Tenth People's Hospital
2024
Tongji University
2024
Beijing National Laboratory for Molecular Sciences
2020-2024
Institute of Chemistry
2020-2024
University of Chinese Academy of Sciences
2023-2024
Yale University
2018-2024
University of New Haven
2024
Coronavirus disease 2019 (COVID-19) has become a worldwide threat to humans, and neutralizing antibodies have therapeutic potential. We purified more than 1,000 memory B cells specific SARS-CoV-2 S1 or its RBD (receptor binding domain) obtain 729 paired heavy- light-chain fragments. Among these, 178 test positive for antigen binding, the majority of top 17 binders with EC50 below 1 nM are binders. Furthermore, we identify 11 antibodies, eight which show IC50 within 10 nM, best one, 414-1,...
Excessive oxidative stress in cancer cells can induce cell death. Anticancer activity and drug resistance of chemotherapy are closely related to the redox state tumor cells. Herein, five lipophilic Pt(IV) prodrugs were synthesized on basis most widely used anticancer cisplatin, whose efficacy intracellular state. Subsequently, a series cisplatin-sensitive drug-resistant lines as well three patient-derived primary ovarian have been selected screen those prodrugs. To verify if disruption...
Endosomal escape is a key step for intracellular drug delivery of nucleic acids, but reliable and sensitive methods its quantitation remain an unmet need. In order to rationally optimize the mRNA transfection efficiency library polymeric materials, we designed deactivated Renilla luciferase-derived molecular probe whose activity can be restored only in cytosol. This coencapsulated with same vehicle, thereby accurately measuring endosomal efficiency. We examined poly(amine-co-ester) (PACE)...
Efficient endosomal escape is the most essential but challenging issue for siRNA drug development. Herein, a series of quaternary ammonium-based amphiphilic triblock polymers harnessing an elaborately tailored pH-sensitive hydrophobic core were synthesized and screened. Upon incubating in pH environment (pH 6.5–6.8), mPEG45-P(DPA50-co-DMAEMA56)-PT53 (PDDT, optimized polymer) nanomicelles (PDDT-Ms) PDDT-Ms/siRNA polyplexes rapidly disassembled, leading to promoted cytosolic release...
Nanoparticle-based drug delivery systems have the potential to revolutionize medicine, but their low vascular permeability and rapid clearance by phagocytic cells limited medical impact. Nanoparticles delivered at in utero stage can overcome these key limitations due high rate of angiogenesis cell division fetal tissue under-developed immune system. However, very little is known about nanoparticle development. In this report, using Ai9 CRE reporter mice, we demonstrate that lipid (LNP) mRNA...
RNAi approaches have been widely combined with platinum-based anticancer agents to elucidate cellular responses and target gene products that mediate acquired resistance. Recent work has demonstrated platination of siRNA prior transfection may negatively influence efficiency based on the position sequence its guanosine nucleosides. Here, we used detailed spectroscopic characterization demonstrate rapid formation Pt-guanosine adducts within 30 min after coincubation oxaliplatin [OxaPt(II)] or...
Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven be refractory cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) significantly increase loading on a per-vehicle basis as compared antibody-drug (ADCs). Their intraperitoneal administration enabled triggered release active MMAE toxin inhibit tumor growth extend animal survival >90...
We first officially propose the brand-new concept of “biosafety materials”, which utilizes materials science to solve biosafety problems.
Abstract The in vivo fate of chemotherapeutic drugs plays a vital role understanding the therapeutic outcome, side effects, and mechanism. However, lack imaging abilities drugs, tedious labeling processes, premature leakage agents result loss fidelity between signals. Herein, an amphiphilic polymer is created by copolymerization near‐infrared‐II (NIR‐II) fluorophore tracer (T) anticancer Pt(IV) prodrug (D) cisplatin hand‐holding manner into one chain for first time. obtained Polyplatin DT...
To investigate the effect and mechanism of microRNA-92b-3p (miR-92b-3p) targeting Homeobox D10 (HOXD10) on proliferation, migration, invasion gastric cancer, we detected expression miR-92b-3p HOXD10 in SGC-7901 cells. The effects or invasion, matrix metalloproteinase (MMP)-2/9 cells were measured by Cell Counting Kit-8 assay, Transwell Western blot, respectively. results showed that was increased, decreased cells, compared with human normal epithelial GES-1. Functional experiments...
Imperatorin (IMP) is a naturally occurring furanocoumarin with beneficial biological activities such as anticancer, antioxidant, and neuromodulatory properties. Currently, the protective effects mechanisms of IMP on oxidative stress experienced by mouse oocytes after vitrification-thawing remain unclear. To investigate influence oocyte development vitrification-thawing, we added different concentrations to vitrification thawing media. Results indicated that addition 40 μM enhanced post-thaw...
We synthesized stable supramolecular nanoparticles based on the high affinity of carboranes and β-cyclodextrin for efficient photodynamic therapy.
The A disintegrin and metalloproteinase 9 (ADAM9) protein has been suggested to promote carcinoma invasion appears be overexpressed in various human cancers. However, its role rarely investigated gliomas and, thus, the current study we have evaluated ADAM9 expression examined relevance of prognosis glioma patients. Clinical characteristics, RNA sequence data, case follow-ups were reviewed for 303 patients who had histological, confirmed gliomas. between lower-grade (LGG) glioblastoma (GBM)...
There is a strong correlation between consuming high amounts of heme and an elevated risk developing various types cancer, including colorectal cancer. However, the role metabolism-related genes (HRGs) in cancer remains unclear. Our study aimed to identify prognostic markers for patients based on these genes.The metabolism score was assessed using gene set variation analysis (GSVA). Potential HRGs were identified from TCGA-COAD dataset LASSO COX regression analyses. The expression level...