A5100648571- Intraoperative Neuromonitoring and Anesthetic Effects
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Facial Nerve Paralysis Treatment and Research
- Anesthesia and Pain Management
- Functional Brain Connectivity Studies
- Intensive Care Unit Cognitive Disorders
- Vascular Malformations Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Neurological disorders and treatments
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Cerebrovascular and Carotid Artery Diseases
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Trigeminal Neuralgia and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
Beijing Institute of Neurosurgery
2016-2025
Capital Medical University
2016-2025
Beijing Shijitan Hospital
2021-2023
Beijing Tian Tan Hospital
2015-2022
Ningxia Medical University
2022
National Clinical Research Center for Digestive Diseases
2022
Chinese Institute for Brain Research
2022
Eye & ENT Hospital of Fudan University
2022
Daqing Oilfield General Hospital
2021
Capital University
2021
OBJECTIVE Diffusion tensor imaging (DTI) and diffusion tractography (DTT) have the ability to noninvasively visualize changes in white matter tracts, as well their relationships with lesions other structures. DTI/DTT has been increasingly used improve safety results of surgical treatment for eloquent areas, such brainstem cavernous malformations. This study aimed investigate application value glioma surgery validate spatial accuracy reconstructed corticospinal tracts (CSTs). METHODS A...
We hypothesized that the addition of dexmedetomidine in a clinically relevant dose to propofol-remifentanil anesthesia regimen does not exert an adverse effect on motor-evoked potentials (MEP) and somatosensory-evoked (SSEP) adult patients undergoing thoracic spinal cord tumor resection. Seventy-one were randomized into three groups. Propofol group (n = 25): regimenand dosage was adjusted maintain bispectral index (BIS) between 40 50. DP 23): Dexmedetomidine (0.5 μg/kg loading infused over...
Isoflurane, a widely used volatile anesthetic, induces neuronal apoptosis and memory impairments in various animal models. However, the potential mechanisms effective pharmacologic agents are still not fully understood. The p38MAPK/ATF-2 pathway has been proved to regulate cell survival inflammation. Besides, atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, exerts neuroprotective effects. Thus, this study aimed explore influence of atorvastatin on isoflurane-induced...
OBJECTIVE Craniopharyngiomas are rare, benign brain tumors that primarily treated with surgery. Although the extended endoscopic endonasal approach (EEEA) has evolved as a more reliable surgical alternative and yields better visual outcomes than traditional craniotomy, postoperative deterioration remains one of most common complications, relevant risk factors still poorly defined. Hence, identifying developing predictive model for is indeed necessary. However, there lack research on these...
Small faults developed in coal seams are one of the major causes mine accidents. Accurately predicting small fields is an urgent requirement for efficient and safe production mines. This article proposes a new fault identification method that combines empirical mode decomposition seismic texture attribute extraction to address problem large errors caused by noise results prediction. Firstly, basic principles were studied, then recognition ability this was tested analysed based on forward...
ABSTRACT Schwannoma surgeries pose a significant risk of postoperative neurological impairment. While intraoperative neuromonitoring (IONM) has improved surgical outcomes, it offers an indirect assessment neural structures and functions. However, during the surgeries, is not feasible to achieve comprehensive visualization nerves. To address this limitation, we introduced multi‐channel flexible microelectrode array (FMEA) characterized by its exceptional resolution, consistent conductivity,...
The current study aimed to clarify the representation of early postoperative seizures (EPSs) in different glioma subtypes under 2021 WHO classification, explore risk factors for EPSs patients, and investigate clinical impact on seizure survival outcomes. Data from 78 patients were analyzed. differences clinical-pathological features between with those without compared using appropriate statistical methods. Multivariate binary logistic regression analysis was subsequently conducted potential...
The current study aimed to investigate brain network abnormalities in glioma-related epilepsy (gre) patients through high-density electroencephalography (eeg) data analysis. included 35 with newly diagnosed frontal gliomas. All participants underwent 128-channel resting-state EEG recordings before surgery. Afterward, graph theory and microstate analyses were performed, the resulting metrics compared between GRE those without GRE. topology analysis demonstrated that group had a higher...
The A disintegrin and metalloproteinase 9 (ADAM9) protein has been suggested to promote carcinoma invasion appears be overexpressed in various human cancers. However, its role rarely investigated gliomas and, thus, the current study we have evaluated ADAM9 expression examined relevance of prognosis glioma patients. Clinical characteristics, RNA sequence data, case follow-ups were reviewed for 303 patients who had histological, confirmed gliomas. between lower-grade (LGG) glioblastoma (GBM)...
We analyzed the frequency of heart rate (HR) changes related to seizures, and we sought identify influencing factors these during partial summarize regularity HR gain some insight into mechanisms involved in neuronal regulation cardiovascular function. To date, detailed information on seizures by multiple linear regression analysis remains scarce. Using video-electroencephalograph (EEG)-electrocardiograph (ECG) recordings, retrospectively assessed 81 patients a total 181 including 27 simple...
Transcranial electrical motor-evoked potentials (TceMEPs) can provide early warning of possible motor compromise during surgery. There are fewer reports comparing the effects etomidate and propofol infusion on TceMEPs when used for maintenance anesthesia guided by comparable values bispectral index (BIS) spinal surgery.Thirty-three patients scheduled surgery were randomly divided into 2 groups: (PR, n=18) (ER, n=15). Anesthesia was maintained with either or combined remifentanil. The rates...
Fluorine-18-fluorodeoxyglucose positron-emission tomography (18F-FDG-PET) is widely used to help localize the hypometabolic epileptogenic focus for presurgical evaluation of drug-refractory epilepsy patients. Two voxel-based brain mapping methods interpret 18F-FDG-PET, statistical parametric (SPM) and three-dimensional stereotactic surface projection (3D-SSP), improve detection rate seizure foci. This study aimed compare consistency epileptic between SPM 3D-SSP 18F-FDG-PET analysis.We...
<h3>Trial design</h3> Hypoglossal–facial nerve (HN-FN) neurorrhaphy is a method commonly used to treat facial palsy when the proximal stump of injured FN unavailable. Since classic HN-FN that needs section not suitable for incomplete palsy, we investigated modified consists 'side'-to-side neurorrhaphy, retaining remaining or spontaneously regenerated axons while preserving hemihypoglossal function. <h3>Methods</h3> To improve axonal regeneration, first time predegenerated sural autograft...
In clinic, perioperative neurocognitive disorder is becoming a common complication of surgery in old patients. Neuroinflammation and blood–brain barrier (BBB) disruption are important contributors for cognitive impairment. Atorvastatin, as strong HMG-CoA reductase inhibitor, has been widely used clinic. However, it remains unclear whether atorvastatin could prevent anesthesia surgery-induced BBB injury by its anti-inflammatory property. this study, aged C57BL/6J mice were to address...
Insular gliomas have complex anatomy and microvascular supply that make resection difficult. Furthermore, of insular glioma is associated with a significant risk postoperative ischemic complications. Thus, this study aimed to assess the incidence complications related resection, determine its factors, describe single surgeon's experience artery-preserving tumor resection. We enrolled 75 consecutive patients who underwent transcortical Preoperative demographic, clinical, radiological...
Dexmedetomidine (DEX) has been demonstrated to protect against ropivacaine (Ropi)-induced neuronal damages. This study was conducted explore the protective role of DEX in Ropi-induced pyroptosis and provide a strategy eliminate neurotoxicity. The impacts different concentrations Ropi on neurotoxicity SK-N-SH cells were evaluated by cell counting kit-8 assay lactic dehydrogenase kits. Levels nuclear factor erythroid 2-related 2 (Nrf2), heme oxygenase 1 (HO-1), NLR family pyrin domain...
This study investigated the efficacy of multiple intraoperative monitoring techniques including indocyanine green angiography (ICGA), somatosensory evoked potential (SSEP) and motor (MEP) in clinical outcome microneurosurgical treatment for anterior circulation cerebral aneurysm. Fifty-two aneurysms (Hunt Hess [H&H] grades 0, 1 or 2) from 45 Chinese in-patients were completely clipped. In one patient, ICGA directed neurosurgeons to readjust aneurysmal clips order eliminate a residual...