A5079247391- Nanoparticles: synthesis and applications
- Heavy Metal Exposure and Toxicity
- Selenium in Biological Systems
- Glioma Diagnosis and Treatment
- Carbon and Quantum Dots Applications
- Graphene and Nanomaterials Applications
- Sperm and Testicular Function
- Healthcare and Environmental Waste Management
- Advanced Nanomaterials in Catalysis
- Quantum Dots Synthesis And Properties
- Trace Elements in Health
- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- Anesthesia and Neurotoxicity Research
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Tryptophan and brain disorders
- Meningioma and schwannoma management
- MRI in cancer diagnosis
Southeast University
2014-2024
University of Chinese Academy of Sciences
2023
Xinjiang Institute of Ecology and Geography
2023
Chinese Academy of Sciences
2023
China Southern Power Grid (China)
2022
Tianjin University of Traditional Chinese Medicine
2022
Versus Arthritis
2022
Capital Medical University
2019-2021
Qingdao University
2014-2021
Qingdao Municipal Hospital
2014-2021
Nickel is associated with reproductive toxicity. However, the toxicity of nickel nanoparticles (Ni NPs) unclear. Our goal was to determine association between nanoparticle exposure and According one-generation standard, rats were exposed by gavage we selected indicators including sex hormone levels, sperm motility, histopathology, outcome etc. Experimental results showed increased follicle stimulating (FSH) luteinizing (LH), lowered etradiol (E2) serum levels at a dose 15 45 mg/kg in female...
Abstract Background Graphene quantum dots (GQDs) provide a bright prospect in the biomedical application because they contain low-toxic compounds and promise imaging of deep tissues tiny vascular structures. However, biosafety this novel QDs has not been thoroughly evaluated, especially central nervous system (CNS). The microarray analysis provides hint that nitrogen-doped GQDs (N-GQDs) exposure could cause ferroptosis microglia, which is form cell death dependent on iron overload lipid...
With the applications of quantum dots (QDs) expanding, many studies have described potential adverse effects QDs, yet little attention has been paid to toxicity QDs in liver. The aim this study was investigate cadmium telluride (CdTe) mice and murine hepatoma cells alpha mouse liver 12 (AML 12). CdTe administration significantly increased level lipid peroxides marker malondialdehyde (MDA) livers treated mice. Furthermore, caused cytotoxicity AML a dose- time-dependent manner, which likely...
Abstract Background Along with the wild applications of nitrogen-doped graphene quantum dots (N-GQDs) in fields biomedicine and neuroscience, their increasing exposure to public potential biosafety problem has gained more attention. Unfortunately, understanding adverse effects N-GQDs central nervous system (CNS), considered as an important target nanomaterials, is still limited. Results After we found that caused cell death, neuroinflammation microglial activation hippocampus mice through...
ABSTRACT Nickel nanoparticles (Ni NPs) are associated with reproductive toxicity. However, the mechanisms of toxicity unclear. Our goal was to explore further induced by nickel nanoparticle and involved in this process, including role oxidative stress apoptosis. According one‐generation standard, rats were exposed gavage we selected indicators ultrastructural, reactive oxygen species (ROS), oxidant antioxidant enzymes, cell apoptosis‐related factors. Ultrastructural results ovaries showed...
To explore the health effects of multi-heavy metal exposure, Sprague Dawley (SD) rats were orally given one dose heavy mixtures (HMMs). The eight most common detectable metals in Ningbo area are zinc (Zn), copper (Cu), manganese (Mn), chromium (Cr), nickel (Ni), cadmium (Cd), lead (Pb) and mercury (Hg). In this study, these prepared using compounds sulfate heptahydrate, cupric sulfate, dichloride, potassium dichromate, acetate, methyl chloride with ion mass proportions 1070.0, 312.6, 173.1,...
CS (chitosan) has emerged as a promising non-viral vector for gene delivery because of its ability to form complexes with pDNA (plasmid DNA) and enhance transport across cellular membranes through endocytosis. Complexes may improve transfection efficiency; however, they are not capable sustained DNA release prolonging transfer. In order achieve prolonged CS-DNA complexes, we prepared NP (nanoparticle) complexes. alpha-Methoxy-omega-succinimidylpoly(ethylene glycol) was then conjugated the...
Although it has been reported that fluorescent quantum dots (QDs) have obvious acute toxic effects in vitro, their at low doses or threshold are still unknown. Therefore, we evaluated the biological histocompatibility and vitro toxicity of three types QDs doses. Also, compared with different raw chemical compositions sizes. The results showed concentrations (≤7 μg/mL) had no effect on cell viability membrane damage, oxidative apoptosis DNA damage. However, QD exposure led to a significant...
Silver nanoparticles are used in many commercial products daily life. Exposure to nanosilver has hepatotoxic effects animals. This study investigated the cytotoxicity associated with polyvinylpyrrolidone-coated (23.44 ± 4.92 nm diameter) exposure human hepatoma cell line (HepG2) and normal hepatic (L02), molecular mechanisms induced by HepG2 cells. Nanosilver, doses of 20–160 μg mL −1 for 24 48 h, reduced viability a dose- time-dependent manner membrane leakage mitochondria injury both...
With the rapid expansion of human exposure to silver nanoparticles (AgNPs), genotoxicity screening is critical biosafety evaluation nanosilver. This study assessed DNA damage and chromosomal aberration in hepatoma cell line (HepG2) as well effects on micronucleus bone marrow mice induced by 20 nm polyvinylpyrrolidone-coated nanosilver (PVP-AgNPs) bare (AgNPs). Our results showed that two types AgNPs, doses 20-160 μg/mL, could cause genetic toxicological changes HepG2 cells. The degree cells...
ABSTRACT To investigate the reproductive toxicity and underlying mechanism of nickel nanoparticles (Ni NPs), Caenorhabditis elegans ( C. ) were treated with/without 1.0, 2.5, 5.0 μg cm −2 Ni NPs or microparticles MPs). Generation time, fertilized egg numbers, spermatide activation motility detected. Results indicated, under same treatment doses, that induced higher to than MPs. Reproductive toxicities observed in included a decrease brood size, activation, but an increase generation time...
Abstract This study evaluated the biodistribution and organ oxidative effects of silver nanoparticles (AgNPs) coated with/without polyvinylpyrrolidone (PVP) (AgNP‐20 AgNP‐PVP) in mice; these were administered by gavage at a dose 10‐250 mg/kg body weight per day for 28 days. The results showed that both AgNPs could induce subacute toxicity damage to mice mainly accumulated liver spleen excreted feces. be absorbed into blood might cross blood‐brain barrier, distributed extensively mice....
OBJECTIVE Diffusion tensor imaging (DTI) and diffusion tractography (DTT) have the ability to noninvasively visualize changes in white matter tracts, as well their relationships with lesions other structures. DTI/DTT has been increasingly used improve safety results of surgical treatment for eloquent areas, such brainstem cavernous malformations. This study aimed investigate application value glioma surgery validate spatial accuracy reconstructed corticospinal tracts (CSTs). METHODS A...