A5009114783- Nanoparticles: synthesis and applications
- Heavy metals in environment
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Contact Dermatitis and Allergies
- Occupational and environmental lung diseases
- Bone Tissue Engineering Materials
- Trace Elements in Health
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Arsenic contamination and mitigation
- Advanced Nanomaterials in Catalysis
- Allergic Rhinitis and Sensitization
- Advanced biosensing and bioanalysis techniques
National Institute for Occupational Safety and Health
2017-2024
Centers for Disease Control and Prevention
2024
Health Effects Institute
2018
Morgantown High School
2018
To explore the health effects of multi-heavy metal exposure, Sprague Dawley (SD) rats were orally given one dose heavy mixtures (HMMs). The eight most common detectable metals in Ningbo area are zinc (Zn), copper (Cu), manganese (Mn), chromium (Cr), nickel (Ni), cadmium (Cd), lead (Pb) and mercury (Hg). In this study, these prepared using compounds sulfate heptahydrate, cupric sulfate, dichloride, potassium dichromate, acetate, methyl chloride with ion mass proportions 1070.0, 312.6, 173.1,...
The systemic toxicity of different combinations heavy metal mixtures (HMMs) was studied according to equivalent proportions the eight most common detectable metals found in fish consumption Ningbo area China. ion mass Zn, Cu, Mn, Cr, Ni, Cd, Pb, and Hg were 1070.0, 312.6, 173.1, 82.6, 30.0, 13.3, 6.6, 1.0, respectively. In this study, 10 experimental groups set as follows: M8 (Pb + Cd Ni Cu Zn Mn Cr); M5 M4A Ni); M4B (Cu M3 Mn); Cr; Cu; Zn; Mn; control. Sprague Dawley (SD) rats orally...
Titanium dioxide (TiO2 ) is generally regarded as a nontoxic and nongenotoxic white mineral, which mainly applied in the manufacture of paper, paint, plastic, sunscreen lotion other products. Recently, TiO2 nanoparticles NPs) have been demonstrated to cause chronic inflammation lung tumor formation rats, may be associated with particle size . Considering important role activator protein-1 (AP-1) regulating multiple genes involved cell proliferation induction neoplastic transformation, we...
The fundamental goal of this study was to determine the potential utility a novel humanized Toll-like receptor-4 (hTLR-4) mouse model for future in vivo studies nickel allergy. First, mice both sexes and hTLR-4 expression profiles were incorporated into Local Lymph Node Assay (LLNA) assess skin sensitization. Next, set hTLR-4-positive (female male groups) similarly exposed vehicle control (VC) or 10% NiSO4 on Days 1, 2, 3. Mice euthanized Day 10, lymph node (LN) cellularity assessed, LN...
Occupational exposures to Copper Oxide (CuO) nanoparticles havebeen reported be harmful human health, with possible risk of cancer amongworkers from many sectors. CuOnanoparticles have not, our knowledge, been extensively examined forpotential carcinogenic toxicological effects. To investigate the mechanisms ofCuO‐induced pathogenesis, effect metal oxide fine and on antioxidantresponse ROS generation were investigated. The results indicated that CuO caused a2‐fold increase in AP‐1 activity...
Silica particles are considered to be fibrogenic agents and established carcinogens, but the mechanisms for disease initiation progression not well understood. Earlier studies demonstrated that tumor suppressor gene, PDCD4, its upstream regulator, miR‐21, may as oncogenes novel cancer prevention or anti‐cancer therapies. The present study examined whether freshly fractured silica induce cell transformation. data indicated chronically exposed human lung epithelial BEAS‐2B JB6 cells low‐dose...
Occupational exposures to copper dusts or fumes have beenreported be harmful human health, with possible risk of cancer amongcopper smelting workers. Copper (II)oxide (CuO) nanoparticles not, our knowledge, been extensively examinedfor potential carcinogenic genotoxic effects. To investigate the mechanismsof CuO‐induced pathogenesis, effect CuO on AP‐1‐MAPKs and ROS generation were investigated. The results indicated that caused a 2‐fold increase in AP‐1 activity JB6 cells. induction...
Occupational exposures to metal oxide nanoparticles have been reported be harmful human health, with possible risk of cancer among workers from many sectors. Metal Oxide not, our knowledge, extensively examined for potential carcinogenic or genotoxic effects. To investigate the mechanisms TiO 2, WC‐Co, and CuO‐induced pathogenesis, effect fine on AP‐1‐MAPKs ROS generation were investigated. The results indicated that CuO, andTiO 2 caused a 2‐fold increase more in AP‐1 activity JB6 cells....