A5082507354- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Nuts composition and effects
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- Plant biochemistry and biosynthesis
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Peanut Plant Research Studies
- Plant Molecular Biology Research
- Optical measurement and interference techniques
- Transcranial Magnetic Stimulation Studies
- Crystallization and Solubility Studies
- Vagus Nerve Stimulation Research
- X-ray Diffraction in Crystallography
- Circular RNAs in diseases
- Plant and Fungal Interactions Research
- Plant tissue culture and regeneration
- Autism Spectrum Disorder Research
- Genetic Mapping and Diversity in Plants and Animals
- Plant Physiology and Cultivation Studies
- Epilepsy research and treatment
Capital Medical University
2016-2025
Institute of Crop Sciences
2022-2025
Chinese Academy of Agricultural Sciences
2022-2025
Beijing Emergency Medical Center
2019-2025
National Clinical Research Center for Digestive Diseases
2022-2024
State Grid Corporation of China (China)
2024
Xuan Wu Hospital of the Capital Medical University
2024
Guiyang Medical University
2022-2024
Chinese Academy of Forestry
2018-2024
China Southern Power Grid (China)
2023-2024
Astrocyte and microglia activation are well-known features of temporal lobe epilepsy that may contribute to epileptogenesis. However, the mechanisms underlying glia not well understood. Long non-coding RNA (lncRNA) H19 has diverse functions depending on physiological or pathological state, its role in is unknown. We previously demonstrated was significantly upregulated latent period be associated with cell proliferation immune inflammatory responses. therefore speculated involved hippocampal...
Abstract Temporal lobe epilepsy (TLE) is one of the most common types intractable epilepsy, characterized by hippocampal neuron damage and sclerosis. Long noncoding RNAs (lncRNAs) have been increasingly recognized as posttranscriptional regulators. However, their expression levels functions in TLE remain largely unknown. In present study, rat model used to explore profiles lncRNAs hippocampus epileptic rats using microarray analysis. Our results demonstrate that H19 pronouncedly...
Parkinson's disease (PD) is a common movement disorder for which diagnosis mainly depends on the medical history and clinical symptoms. Exosomes are now considered an additional mechanism intercellular communication, allowing cells to exchange proteins, lipids, genetic material. Long noncoding (lnc) RNA in exosomes plays critical role many diseases, including neurodegenerative disease.To study expression differences lncRNAs peripheral blood of PD patients compared with healthy individuals...
Abstract Objectives Glial cell activation contributes to the inflammatory response and occurrence of epilepsy. Our preliminary study demonstrated that long non‐coding RNA, H19, promotes hippocampal glial during epileptogenesis. However, precise mechanisms underlying this effect remain unclear. Materials methods H19 let‐7b were overexpressed or silenced using an adeno‐associated viral vector in vivo. Their expression a kainic acid‐induced epilepsy model was evaluated by real‐time quantitative...
Abstract Objective To compare the efficacy of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) on reducing levodopa‐induced dyskinesia (LID) in Parkinson’s disease, to explore potential underlying mechanisms. Methods We retrospectively assessed clinical outcomes 43 patients with preoperative LID who underwent DBS targeting STN (20/43) or GPi (23/43). The primary outcome was change from baseline Unified Dyskinesia Rating Scale (UDysRS) secondary...
The oil content, fatty acid, quality and oxidation stability of seeds four woody plants (pecan, Camellia oleifera, Torreya grandis walnut) were analyzed. results showed that pecan had the strongest antioxidant activity, variation range FFA, peroxide value(PV), UV absorption, carbonyl value(CV) OSI lowest; C. oleifera T. next, walnut greatest range; besides, contained higher tocopherol total phenol(TP) content. Correlation analysis that, was significantly positively correlated with OA, TP,...
Accurately and objectively quantifying the clinical features of Parkinson's disease (PD) is crucial for assisting in diagnosis guiding formulation treatment plans. Therefore, based on data multi-site motor features, this study aimed to develop an interpretable machine learning (ML) model classifying "OFF" "ON" status patients with PD, as well explore that are most associated changes symptoms.
Pecan ( Carya illinoinensis) is an important tree nut throughout the world. The high concentration of flavonoid in its kernels makes it excellent food with health benefits. However, molecular basis biosynthesis pecan remains unclear, which hinders quality breeding this plant. Therefore, order to find crucial genes involved biosynthesis, changes profiles and transcriptomes at four developmental stages (late water, gel, dough, mature stages) were analyzed. As a result, highest levels total...
Drought is a major abiotic stress affecting maize development and growth. Unravelling the molecular mechanisms underlying drought tolerance enhancing of great importance. However, due to complexity genome multiplicity mechanisms, identifying genetic effects remains challenging. Using mixed linear model (MLM) based on 362 inbred lines, we identified 40 associated loci 150 candidate genes with survival rates. Concurrently, transcriptome analysis was conducted for five - tolerant sensitive...
Summary Objective We aimed to study the networks’ mechanism of metabolic covariance networks in mesial temporal lobe epilepsy (mTLE), through examining brain value fluorine‐18‐fluorodeoxyglucose positron emission tomography ( 18 F‐FDG‐PET). Methods F‐FDG‐PET images from 16 patients with mTLE were analyzed using local and global network (MCN) approaches, including whole pattern analysis (WMPA), hippocampus‐based (h‐) MCN, (w‐) edge‐based connectivity (EBCA). Results WMPA showed a typical...
Fluorine-18-fluorodeoxyglucose positron-emission tomography (18F-FDG-PET) is widely used to help localize the hypometabolic epileptogenic focus for presurgical evaluation of drug-refractory epilepsy patients. Two voxel-based brain mapping methods interpret 18F-FDG-PET, statistical parametric (SPM) and three-dimensional stereotactic surface projection (3D-SSP), improve detection rate seizure foci. This study aimed compare consistency epileptic between SPM 3D-SSP 18F-FDG-PET analysis.We...
Positron emission tomography (PET) scan with tracer [18F]-fluorodeoxy-glucose (18F-FDG) is widely used to measure the glucose metabolism in neurodegenerative disease such as Idiopathic Parkinson's (IPD). Previous studies using 18F-FDG PET mainly focused on motor or non-motor symptoms but not severity of IPD. In this study, we aimed determine metabolic patterns different stages IPD defined by Hoehn and Yahr rating scale (H-Y scale) identify regions brain that play critical roles progression....
Dielectrophoretic (DEP) droplet dispensing using dielectric-coated coplanar electrode structures provides an ideal platform for testing smart control systems high-speed microfluidic devices. Open-loop of DEP is not sufficiently robust precision because unavoidable surface property variations the substrates and other parameters such as liquid viscosity introduce uncertainty in motion. Closed-loop employing distributed optical sensors feedback provide flexibility, sensitivity, reliability. In...
Background: Over past two decades, vagus nerve stimulation (VNS) has been widely used and reported to alleviate seizure frequency worldwide, however, so far, only hundreds of patients with pharmaco-resistant epilepsy (PRE) have treated VNS in mainland China. The study aimed evaluate the effectiveness for Chinese PRE compare its relationship age cohort gender. Methods: We retrospectively assessed clinical outcome 94 PRE, who were at Beijing Fengtai Hospital Tiantan between November 2008 April...
Vagus nerve stimulation balanced disrupted default-mode network and salience in a postsurgical epileptic patient Kailiang Wang,1,2 Qi Chai,1 Hui Qiao,1 Jianguo Zhang,2,3 Tinghong Liu,1,2 Fangang Meng,1,2 1Beijing Neurosurgical Institute, Capital Medical University, 2Beijing Key Laboratory of Neurostimulation, 3Department Neurosurgery, Beijing Tiantan Hospital, Beijing, People’s Republic China Introduction: In recent years, treatment intractable epilepsy has become more challenging, due...
We have proposed a virtual quadratic Newton rings phase-shifting moiré-fringes measurement method in nonnull interferometer to measure the large radius of curvature for spherical surface. In polar coordinate system, linear carrier testing interferogram and form moiré fringes. It is possible retrieve wavefront difference data between standard surface from fringes after low-pass filtering. Based on data, we deduced precise formula calculate system. calculated retrace error using...