A5100416465- Advanced biosensing and bioanalysis techniques
- Viral-associated cancers and disorders
- Biosensors and Analytical Detection
- Cytomegalovirus and herpesvirus research
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Ecology and Vegetation Dynamics Studies
- Species Distribution and Climate Change
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Advancements in Battery Materials
- Cancer-related molecular mechanisms research
- Peatlands and Wetlands Ecology
- Forest, Soil, and Plant Ecology in China
- Advanced Nanomaterials in Catalysis
- Virus-based gene therapy research
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Microbial Community Ecology and Physiology
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- MicroRNA in disease regulation
Xiamen University
2018-2025
Hunan Normal University
2005-2025
Minzu University of China
2022-2025
Dalian Minzu University
2022-2025
Ningbo University
2023-2025
Southern University of Science and Technology
2025
Guangxi Medical University
2024
Tongji University
2024
State Key Laboratory of Pollution Control and Resource Reuse
2024
Central South University
2023-2024
Cancer-associated fibroblasts (CAFs) are critically involved in gemcitabine (GEM) resistance pancreatic ductal adenocarcinoma (PDAC). However, the underlying mechanism by which CAFs promote chemotherapy remains unexplored. Here, we explored role of circRNAs CAF-induced GEM PDAC. circRNA sequencing and quantitative real-time PCR (qRT-PCR) were utilized to screen CAF-specific circRNAs. The effects CAF circFARP1 expression on tumor cells assessed vitro vivo. RNA-seq, RNA pulldown,...
Heavy-metal contamination in river and ocean is a critical environmental issue that endangers marine ecosystems human health. Therefore, conducting extensive research to devise effective mitigation measures imperative. Sediment samples were taken randomly throughout the study area. Analysis was done determine presence of different metals, including arsenic, cadmium, chromium, nickel, copper, zinc, lead, manganese. The assessment pollution levels by using various indicators “geo-accumulation...
The CRISPR/Cas gene editing system has been successfully applied to combating bacteria, cancer, virus, and genetic disorders. While viral vectors have used for the delivery of CRISPR/Cas9 system, time required insert cloning, virus packaging standardization, hinders its efficient use. Additionally, high molecular weight Cas9 endonuclease makes it not easy packing into vehicles. Herein we report self-assembly gold nanoclusters (AuNCs) with SpCas9 protein (SpCas9–AuNCs) under physiological...
Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. One effective approaches overcome MDR use nanoparticle-mediated gene silence chemotherapeutic export proteins by RNA interference increase drug accumulation in resistant cells. In this work, new co-delivery system, DOX-PLGA/PEI/P-gp shRNA nanobubbles (NBs) around 327 nm, doxorubicin (DOX) MCF-7 human breast was designed and developed. Positively charged polyethylenimine (PEI) were modified onto surface...
ABSTRACT While glutamine is a nonessential amino acid that can be synthesized from glucose, some cancer cells primarily depend on for their growth, proliferation, and survival. Numerous types of also asparagine cell proliferation. The underlying mechanisms the requirement in different contexts remain unclear. In this study, we show oncogenic virus Kaposi’s sarcoma-associated herpesvirus (KSHV) accelerates metabolism glucose-independent proliferation by upregulating expression numerous...
Viruses are associated with up to 15% of human cancer. MicroRNAs (miRNAs) encoded by numerous oncogenic viruses including Kaposi's sarcoma-associated herpesvirus (KSHV) play significant roles in regulating the proliferation and survival virus-induced cancer cells, hence representing attractive therapeutic targets. Here, we report that specific inhibition viral miRNAs carbon dots (Cdots)-mediated delivery locked nucleic acid (LNA)-based suppressors inhibit KSHV-associated primary effusion...
Glycosylation alterations of cell surface proteins are often observed during the progression malignancies. The specific N-glycans were profiled in hepatocellular carcinoma (HCC) with clinical tissues (88 tumor and adjacent normal tissues) corresponding serum samples HCC patients. level core-α-1,6-fucosylated triantennary glycan (NA3Fb) increased both on patients (p < 0.01). Additionally, change NA3Fb was not influenced by Hepatitis B virus (HBV)and cirrhosis. Furthermore, mRNA protein...
Abstract mTORC1, a central controller of cell proliferation in response to growth factors and nutrients, is dysregulated cancer. Whereas arginine activates it overridden by high expression cytosolic sensor for mTORC1 subunit 1 (CASTOR1). Because cancer cells often encounter low levels an alternative mechanism might exist regulate CASTOR1 expression. Here we show K29-linked polyubiquitination degradation E3 ubiquitin ligase RNF167. Furthermore, AKT phosphorylates at S14, significantly...
Topography and soil factors are known to play crucial roles in the species composition of plant communities subtropical evergreen-deciduous broadleaved mixed forests. In this study, we used a systematic quantitative approach classify community types forests Hubei Province (central China), then quantified relative contribution drivers responsible for variation diversity. We classified study area into 12 types. Of these, diversity indices three were significantly higher than those others. each...
B7 family members and their receptors play key roles in regulating T cell responses, constitute very attractive targets for developing immunotherapeutic drugs. V-Set Immunoglobulin domain containing 3 (VSIG3), a ligand the novel immune checkpoint V-domain immunoglobulin suppressor of activation (VISTA), can significantly inhibit functions. Inhibitors targeting VISTA/VSIG3 pathway are great significance tumor immunology. Here, we show crystal structure extracellular (ECD) human VSIG3 protein...
IKKε is a traditional antiviral kinase known for positively regulating the production of type I interferon (IFN) and expression IFN-stimulated genes (ISGs) during various virus infections. However, through an inhibitor screen targeting cellular kinases, we found that plays crucial role in lytic replication Kaposi’s sarcoma-associated herpesvirus (KSHV). Mechanistically, KSHV replication, undergoes significant SUMOylation at both Lys321 Lys549 by viral SUMO E3 ligase ORF45. This event leads...
The numerous high-risk carcinogenic types of human papillomavirus (HR-HPV) that lack vaccine protection underscore the urgent need to develop broader-spectrum HPV vaccines. This study addresses this by focusing on HR-HPV 53, 56, and 66, which are not currently targeted existing It introduces an effective method for their soluble expression, as well mutants, within Escherichia coli expression system. Through strategic homologous loop swapping among HPV53, HPV56, HPV66, we designed twenty...