A5101993543- RNA modifications and cancer
- Immune Cell Function and Interaction
- Nanocomposite Films for Food Packaging
- Viral-associated cancers and disorders
- Cancer-related gene regulation
- Endodontics and Root Canal Treatments
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- Tissue Engineering and Regenerative Medicine
- Immune Response and Inflammation
- Diagnosis and treatment of tuberculosis
- HVDC Systems and Fault Protection
- T-cell and B-cell Immunology
- Amoebic Infections and Treatments
- Advanced biosensing and bioanalysis techniques
- Protein Hydrolysis and Bioactive Peptides
- Dental Implant Techniques and Outcomes
- Viral Infectious Diseases and Gene Expression in Insects
- Drilling and Well Engineering
- interferon and immune responses
- Chemical Reactions and Isotopes
- Neuropeptides and Animal Physiology
- Postharvest Quality and Shelf Life Management
- Phytochemicals and Antioxidant Activities
- Cancer-related molecular mechanisms research
UPMC Hillman Cancer Center
2020-2025
University of Pittsburgh Medical Center
2025
Air Force Medical University
2001-2024
National Clinical Research
2024
First Affiliated Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Xijing Hospital
2013
Beijing University of Technology
2011
Epigenetic changes are present in many physiological and pathological processes. The N6-methyladenosine (m6A) modification is the most common eukaryotic mRNA. However, role of m6A diabetic nephropathy (DN) remains elusive. Here, we found that was significantly upregulated kidney type 1 2 mice, which caused by elevated levels METTL3. Moreover, METTL3 increased podocyte renal biopsy from patients with DN, related to damage. knockout reduced inflammation apoptosis high glucose (HG)-stimulated...
Viruses are associated with up to 15% of human cancer. MicroRNAs (miRNAs) encoded by numerous oncogenic viruses including Kaposi's sarcoma-associated herpesvirus (KSHV) play significant roles in regulating the proliferation and survival virus-induced cancer cells, hence representing attractive therapeutic targets. Here, we report that specific inhibition viral miRNAs carbon dots (Cdots)-mediated delivery locked nucleic acid (LNA)-based suppressors inhibit KSHV-associated primary effusion...
Periodontitis is a chronic inflammatory disease that causes loss of periodontal support tissue. Our objective was to investigate the mechanism by which METTL3-mediated N6-methyladenosine modification regulates osteogenic differentiation through lncRNA in mesenchymal stem cells patients with periodontitis (pPDLSCs).
Abstract RNA alternative splicing is a fundamental cellular process implicated in cancer development. Kaposi’s sarcoma-associated herpesvirus (KSHV), the etiological agent of multiple human malignancies, including sarcoma (KS), remains significant concern, particularly AIDS patients. A CRISPR-Cas9 screening matched primary rat mesenchymal stem cells (MM) and KSHV-transformed MM (KMM) identified key factors involved KSHV-induced transformation. To elucidate mechanisms by which KSHV-driven...
Although several evidences suggesting the vital roles that innate immunity plays in persistence and elimination of chronic hepatitis B virus (CHB) infection, exact mechanism is still complicated. Here, we successfully polarized monocytes derived from healthy human peripheral blood mononuclear cells (PBMCs) into M1/M2 macrophages detected effects core antigen (HBcAg) on polarization function via Toll-like receptor (TLR) 2 signaling pathway. The results showed HBcAg had a negligible impact M1...
Routine examinations have a low specificity and positive rate for the diagnosis of peritoneal lesions. This study aimed to evaluate diagnostic value safety ultrasound-guided percutaneous lesion biopsies in patients with ascites and/or abdominal distension unclear causes.A retrospective analysis was performed 153 consecutive causes. All showed abnormalities peritoneum or greater omentum after ultrasonography, underwent using Bard auto-biopsy gun 18- 16-gauge biopsy needles.The success...
Abstract BackgroundRegenerative medicine and tissue engineering have brought new therapeutic prospects to the treatment of soft defects, but selection seed cells is key treatment. Adipose-derived stem (ASCs) always been a popular candidate for because their rich sources, easy access, high plasticity, strong value-added capabilities. The purpose current study explore role PACAP -derived peptide MPAPO on adipogenic differentiation ASCs its molecular mechanism.MethodsThe effect proliferation...