A5046108342- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Oral and Maxillofacial Pathology
- Ferroptosis and cancer prognosis
- Sinusitis and nasal conditions
- Renal and related cancers
- Chemotherapy-induced organ toxicity mitigation
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Acute Myocardial Infarction Research
- Esophageal Cancer Research and Treatment
- Ear and Head Tumors
- Fibroblast Growth Factor Research
- Cancer, Lipids, and Metabolism
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Salivary Gland Tumors Diagnosis and Treatment
- RNA modifications and cancer
- Atrial Fibrillation Management and Outcomes
- interferon and immune responses
- Proteoglycans and glycosaminoglycans research
- TGF-β signaling in diseases
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Nanfang Hospital
2025
First Affiliated Hospital of Xinjiang Medical University
2025
Xinjiang Medical University
2025
First Affiliated Hospital of Jiamusi University
2024-2025
Southern Medical University
2025
First Affiliated Hospital of Anhui Medical University
2022-2024
Anhui Medical University
2016-2024
China Pharmaceutical University
2021-2024
Cancer Hospital of Chinese Academy of Medical Sciences
2021
Epigenetic changes are present in many physiological and pathological processes. The N6-methyladenosine (m6A) modification is the most common eukaryotic mRNA. However, role of m6A diabetic nephropathy (DN) remains elusive. Here, we found that was significantly upregulated kidney type 1 2 mice, which caused by elevated levels METTL3. Moreover, METTL3 increased podocyte renal biopsy from patients with DN, related to damage. knockout reduced inflammation apoptosis high glucose (HG)-stimulated...
Hypertension is a primary modifiable risk factor for cardiovascular diseases, which often induces renal end-organ damage and complicates chronic kidney disease (CKD). In the present study, histological analysis of human samples revealed that hypertension induced mtDNA leakage promoted expression stimulator interferon genes (STING) in epithelial cells. We used angiotensin II (AngII)- 2K1C-treated mouse kidneys to elucidate underlying mechanisms. Abnormal packing caused by AngII...
MLKL is a central mediator for necroptosis. Its knockout significantly relieves acute kidney injury (AKI). However, its upstream regulatory mechanism in AKI has not been fully elucidated. We recently reviewed how microRNAs (miRNAs), type of well-studied epigenetic regulator, play critical roles AKI. Here, we evaluated miRNAs that potentially target and their function human tubular epithelial cells response to toxic ischemic insults. TargetScan analysis showed miR-194-5P, miR-338-3P,...
The incidence and severity of acute kidney injury (AKI) is increased yearly in diabetic patients. Although the mechanisms for this remain unclear, prevention AKI nephropathy feasible value. As we detected highly activation TGF-β/Smad3 signaling both human biopsy mouse model nephropathy, hypothesized that Smad3 kidneys may increase sensitivity. We tested our hypothesis vitro using TGF-β type II receptor (TGF-βRII) disrupted tubular epithelial cells (TECs) vivo mice with streptozotocin...
Acute kidney injury (AKI) is still a puzzling clinical problem; its pathophysiology not completely understood. Up to now, an effective treatment for AKI lacking. Ferroptosis novel form of regulated cell death characterized by the lethal accumulation lipid hydroperoxides that are dependent on iron and reactive oxygen species mitochondrial dysfunction. Recently, ferroptosis was shown play vital role in such as ischemia-reperfusion folic acid-induced AKI. Melatonin (MT) antioxidant regulates...
The pathophysiological mechanism of acute kidney injury (AKI) is complicated, and effective drugs are still lacking. Ferroptosis a newly discovered regulatory cell death mode characterized by the lethal accumulation iron reactive oxygen species-(ROS-)-dependent lipid hydroperoxides. In recent years, ferroptosis has been confirmed to be involved in progression AKI. Paeoniflorin (PF) traditional Chinese medicine that protective effects on variety diseases including However, which PF attenuates...
Cisplatin is a classic chemotherapeutic agent widely used to treat different types of cancers including ovarian, head and neck, testicular uterine cervical carcinomas. However, cisplatin induces acute kidney injury by directly triggering an excessive inflammatory response, oxidative stress programmed cell death renal tubular epithelial cells. All which lead higher mortality rates in patients. In this study we examined the protective effect protocatechuic aldehyde (PA) vitro cisplatin-treated...
Paeonia lactiflora Pall has been used in Chinese Medicine for thousands of years, especially having anti-inflammatory, sedative, analgesic and other ethnic pharmacological effects. Moreover, Paeoniflorin is the main active ingredient Pall, most are treatment inflammation-related autoimmune diseases. In recent studies have found that a therapeutic effect on variety kidney diseases.Cisplatin (CIS) limited clinical use due to its serious side effects, such as renal toxicity, there no effective...
Circular RNAs (circRNAs) are special non-coding RNA (ncRNA) molecules that play a significant role in many diseases. However, the biogenesis and regulation of circRNAs diabetic nephropathy (DN) largely unknown. Here, we investigated expression profile kidney DN mice through circular sequencing (circRNA-seq). The renal biopsy samples patients with had low circ -0,000,953 expression, which was significantly associated function. Furthermore, loss-of-function gain-of-function experiments were...
To explore the diffusion tensor imaging (DTI) characteristics of thigh muscles in patients with polymyositis (PM) and dermatomyositis (DM).12 known PM/DM 10 healthy volunteers were enrolled this study. Both DTI conventional MR sequences performed on both thighs all subjects. Apparent coefficient (ADC), fractional anisotropy (FA) three eigenvalues compared between group group. One-way analysis variance Student's t-test used for statistical analyses a significance p < 0.05.In group, vastus...
7-Hydroxycoumarin (7-HC), also known as umbelliferon, is commonly found in Chinese herbs (e.g. Eucommiae Cortex, Prunellae Spica, Radix Angelicae Biseratae). Previous laboratory studies have indicated that 7-HC has anti-inflammatory, anti-oxidative, and anti-tumor effects. Cisplatin a widely used chemotherapeutic agent for cancer. Nephrotoxicity one of the limiting side effects cisplatin use.This study aimed to evaluate renoprotective effect cisplatin-induced acute kidney injury (AKI) mouse...
Objective: The aim of this study was to assess the frailty status patients with heart failure undergoing CRT-D and then explore predictive value for all-cause mortality failure-related readmissions in these patients. Methods: We retrospectively included 374 chronic who underwent treatment at First Affiliated Hospital Xinjiang Medical University between June 2020 2024. Based on Tilburg Debilitation Assessment Scale, 175 (46.8%) were classified as frail while 199 (53.2%) non-frail. baseline...
In nasopharyngeal carcinoma (NPC) patients, two radiation target delineation patterns are used for the cervical lymph node area. This study compares efficacy and toxicity of volume planning volumes (PTVs) in NPC patients. retrospective analysis included 387 non-metastatic patients treated with concurrent chemoradiotherapy from January 2017 to December 2020. Patients were divided into groups: 2-PTV group dose gradients (50–54 Gy 66–70 Gy) 3-PTV an additional 60–63 dose. After a median...
Objective: To investigate the association between estimated cumulative low-density lipoprotein cholesterol (LDL-C) exposure and severity of coronary artery disease long-term adverse cardiovascular cerebrovascular events (MACCE) in patients with acute syndrome (ACS). Methods: The subjects were from PROMISE study. This study was a prospective cohort led by Fuwai Hospital, Chinese Academy Medical Sciences, participation eight regional tertiary hospitals as sub-centers, enrolled 18 701 confirmed...
Background: Chronic cadmium exposure can induce the onset and progression of hepatorenal fibrosis; however, its molecular basis is unclear. Insulin-like growth factor-binding protein 7 (IGFBP7) not only a biomarker acute kidney injury (AKI), but also plays functional role in promoting inflammation. Abnormal repair AKI causes fibrosis chronic disease. IGFBP7 has been reported as more sensitive for liver fibrosis. However, requires further investigation. Methods: global conditional knockout...
Acute kidney injury (AKI) is marked by a fast deterioration of the function that may be caused variety factors. Recently, although our group found PPBICA alleviated programmed cell death in AKI, poor water solubility limited its bioavailability. In this research, we screened series derivatives and C-316-1 had best suppressive effect on preventing necroptosis inflammation cisplatin- ischemia/reperfusion-induced AKI vitro vivo with lower toxicity better solubility. Mass spectrometry results...
Acteoside, also known as verbascoside or orobanchin, is a common compound found in many important medicinal plants including the Chinese herb Cistanche deserticola Y. C. Ma, which used for its neuroprotective and memory enhancement properties. We have investigated effects of acteoside using senescent mouse model induced by combination chronic intraperitoneal administration d ‐gal (60 mg/kg/day) oral AlCl 3 (5 once daily 90 days. After 60 days, (30, 60, 120 was orally administered 30 The...