A5100361734- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Extracellular vesicles in disease
- RNA Research and Splicing
- Acute Kidney Injury Research
- Geophysical and Geoelectrical Methods
- Chronic Kidney Disease and Diabetes
- Seismic Imaging and Inversion Techniques
- Lipid metabolism and disorders
- TGF-β signaling in diseases
- Synthesis and Biological Evaluation
- Chemotherapy-induced organ toxicity mitigation
- Ginseng Biological Effects and Applications
- Geomagnetism and Paleomagnetism Studies
- Alcohol Consumption and Health Effects
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Nephrotoxicity and Medicinal Plants
- Renal and related cancers
- Traditional and Medicinal Uses of Annonaceae
- Pharmacological Effects of Natural Compounds
- Peroxisome Proliferator-Activated Receptors
Chengdu University of Technology
2023-2025
Anhui Medical University
2015-2024
Ministry of Education of the People's Republic of China
2009-2024
Guangzhou University of Chinese Medicine
2024
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2024
Guiyang Medical University
2016-2024
Panyu District Central Hospital
2024
City University of Hong Kong
2022-2023
Zhejiang University
2017-2023
Sun Yat-sen University
2020-2023
The role of N6-methyladenosine (m6A) modifications in renal diseases is largely unknown. Here, we characterized the N6-adenosine-methyltransferase-like 3 (METTL3), whose expression elevated tubules different acute kidney injury (AKI) models as well human biopsies and cultured tubular epithelial cells (TECs). METTL3 silencing alleviated inflammation programmed cell death TECs response to stimulation by tumor necrosis factor-α (TNF-α), cisplatin, lipopolysaccharide (LPS), whereas...
Rationale: Ischemia/reperfusion injury (IRI) is a major cause of acute kidney (AKI) that associated with high morbidity and mortality, for which specific treatments are lacking. In this study, we investigated the protective effect human urine-derived stem cells (USCs) their exosomes against IRI-induced AKI to explore potential these as new therapeutic strategy. Methods: USCs were derived from fresh urine. Cell surface marker expression was analyzed by flow cytometry determine characteristics...
Despite increasing evidence that long non-coding RNAs (lncRNAs) widely take part in human diseases, the role of lncRNAs systemic lupus erythematosus (SLE) is largely unknown. In this study, we performed a two-stage study to explore plasma levels five (GAS5, linc0949, linc0597, HOTAIRM1 and lnc-DC) their potential as SLE biomarkers. Compared with healthy controls, GAS5 lnc-DC were significantly decreased (P < 0.001 P = 0.002, respectively) while linc0597 overexpressed patients 0.001). When...
Rationale: TGF-β/Smad signaling is the central mediator for renal fibrosis, however, its functional role in acute kidney injury (AKI) not fully understood. We previously showed Smad2 protects against fibrosis by limiting Smad3 signaling, but details on phase are unclear. Recent evidence that TGF-β/Smad3 may be involved pathogenesis of AKI, so we hypothesized play certain roles AKI due to potential effect programmed cell death. Methods: established a cisplatin-induced mouse model with TGF-β...
// Xiao-ming Meng 1,2 , Yun Zhang 1,3 Xiao-Ru Huang 1 Gui-ling Ren 2 Jun Li and Hui Yao Lan Department of Medicine Therapeutics, Ka Shing Institute Health Sciences, Shenzhen Research Institute, The Chinese University Hong Kong, Kong SAR School Pharmacy, Anhui Medical University, An Hui, China 3 Dermatology, Foshan Hospital TCM, Foshan, Correspondence to: Lan, email: Keywords : treatment for fibrosis, TGF-β/Smads, asiatic acid, naringenin, Pathology section Received July 08, 2015...
Abstract Acute kidney injury (AKI) is a destructive clinical condition induced by multiple insults including ischemic reperfusion, nephrotoxic drugs and sepsis. It characterized sudden decline in renal function, addition to excessive inflammation, oxidative stress programmed cell death of tubular epithelial cells. RIPK1-mediated necroptosis plays an important role AKI. In the present study, we evaluated treatment effects Compound-71 (Cpd-71), novel RIPK1 inhibitor, comparing with...
The present study aimed to examine the expression and function of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/microRNA (miR)-146a/nuclear factor (NF)-κB axis in lipopolysaccharide (LPS)-induced acute kidney injury (AKI). mRNA levels MALAT1 miR-146a AKI tissues cells were detected using reverse transcription-quantitative polymerase chain reaction analysis. NF-κB pathway proteins cell viability assessed western blot analysis MTT method, respectively. secretion inflammatory...
Abstract Background Osteosarcoma is one of the most prevalent primary bone tumours in adolescents. Accumulating evidence shows that aberrant expression long non-coding RNA (lncRNA) NEAT1 and microRNA-483 (miR-483) contribute to epithelial-mesenchymal transition (EMT), invasion metastasis tumour cells. However, potential regulatory effects miR-483 on EMT osteosarcoma remain elusive. Methods The NEAT1, miR-483, signal transducer activator transcription-1 (STAT1), STAT3, EMT-associated markers...