A5101490590- Trace Elements in Health
- Cancer, Lipids, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion Channels and Receptors
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Anesthesia and Neurotoxicity Research
- Obsessive-Compulsive Spectrum Disorders
- Probiotics and Fermented Foods
- Neonatal and fetal brain pathology
- Gut microbiota and health
- Complement system in diseases
- Plant Virus Research Studies
- Mechanical Circulatory Support Devices
- Antimicrobial Peptides and Activities
- Epigenetics and DNA Methylation
- Inflammation biomarkers and pathways
- Medicinal Plants and Neuroprotection
- CRISPR and Genetic Engineering
- Pharmacy and Medical Practices
- Neonatal Respiratory Health Research
- Genetic and Kidney Cyst Diseases
- Enhanced Recovery After Surgery
Zhejiang University
2014-2025
Sir Run Run Shaw Hospital
2014-2025
Suizhou Central Hospital
2025
Peking University Shenzhen Hospital
2024-2025
University of Hong Kong - Shenzhen Hospital
2024-2025
Shantou University
2024-2025
Shantou University Medical College
2024-2025
Yunnan Agricultural University
2023-2024
Chengdu University of Traditional Chinese Medicine
2024
Northwest A&F University
2023
Nicotinamide N-methyltransferase (NNMT) is overexpressed in various human tumors and involved the development progression of several carcinomas. In breast cancer, NNMT was found to be cell lines. However, clinical relevance cancer not yet clear.NNMT expression carcinoma examined by immunohistochemistry, then, its relationship with patient clinicopathological characteristics analyzed. The effects on chemoresistance cells were assessed viability, colony formation, apoptosis assay. NNMT, SIRT1,...
Breast cancer is the leading cause of cancer-related death in women worldwide. Metastatic disease remains primary patients with breast cancer. Basal-like (BLBC) associated aggressive behavior, stem-like phenotype, high histological grade, poor clinical features, and rates recurrences and/or metastasis. However, mechanism BLBC phenotype shaping obscure. Seventeen normal breast/breast cell lines were used for evaluating subtype-markers, WNT targets constitutive components, epithelial...
The present study aimed to examine the expression and function of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/microRNA (miR)-146a/nuclear factor (NF)-κB axis in lipopolysaccharide (LPS)-induced acute kidney injury (AKI). mRNA levels MALAT1 miR-146a AKI tissues cells were detected using reverse transcription-quantitative polymerase chain reaction analysis. NF-κB pathway proteins cell viability assessed western blot analysis MTT method, respectively. secretion inflammatory...
Abstract Background Recent studies have illuminated the complexities of treating advanced bladder cancer (BCa), underscoring importance comprehending its molecular mechanisms for creating novel therapies. While role Karyopherin a2 ( KPNA2 ) in promoting BCa growth is established, precise mechanism remains elusive. Methods To investigate regulatory BCa, we employed a comprehensive approach integrating clinical case data and bioinformatics analysis to evaluate expression tissues. Mechanisms by...
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) that characterized by demyelination, axonal injury and neurological deterioration. Few medications are available for progressive MS, which associated with neuroinflammation confined to CNS compartment. Transient receptor potential melastatin 2 (TRPM2) calcium-permeable, non-selective cation channel plays pathological roles in wide range neuroinflammatory diseases; however, underlying molecular mechanisms TRPM2 remain...
Abstract Mitochondrial DNA (mtDNA) mutations have been associated with Leber’s hereditary optic neuropathy (LHON) and their pathophysiology remains poorly understood. In this study, we investigated the of a LHON susceptibility allele (m.3394T>C, p.30Y>H) in (MT)-ND1 gene. The incidence m.3394T>C mutation was 2.7% cohort 1741 probands LHON. Extremely low penetrances were observed 26 pedigrees carrying only mutation, while 21 families bearing m.3394T>C, together...
Wild pigs usually showed high tolerance and resistance to several diseases in the wild environment, suggesting that gut bacteria of could be a good source for discovering potential probiotic strains. In our study, pig feces were sequenced higher relative abundance genus Lactobacillus (43.61% vs. 2.01%) than domestic pig. A total 11 lactic acid (LAB) strains including two L. rhamnosus, six mucosae, one fermentum, delbrueckii, Enterococcus faecalis species isolated. To investigate synergistic...
Abstract Although increasing evidence has confirmed that the apoptosis of renal tubular epithelial cells (RTECs) is a crucial contributor to onset and development septic acute kidney injury (AKI), pathological mechanism by which RTEC upregulated during AKI not entirely clear. In this study, rat model was induced cecal ligation puncture procedure or lipopolysaccharide (LPS) injection. Four differentially expressed long noncoding RNAs (DE-Lncs) in were determined using RNA-sequencing verified...
Abstract Cytosine and adenosine base editors (CBEs ABEs) are novel genome-editing tools that have been widely utilized in molecular breeding to precisely modify single-nucleotide polymorphisms (SNPs) critical for plant agronomic traits species evolution. However, conventional BE limited achieve C-to-T A-to-G substitutions, respectively. To enhance the applicability of editing technology watermelon, we developed an efficient CGBE editor (SCGBE2.0) by removing uracil glycosylase inhibitor...
Abstract Aim: To conduct the clinical, genetic, and molecular characterization of 494 Han Chinese subjects with tic disorders (TD). Methods: In present study, we performed mutational analysis 22 mitochondrial tRNA genes in a large cohort TD via Sanger sequencing. These variants were then assessed for their pathogenic potential phylogenetic, functional, structural analyses. Results: A total 73 gene (49 known 24 novel) on identified. Among these, 18 that absent or <1% 485 control...
The sensitivity and specificity of immunocytochemical staining mycobacterial antigens in the cytoplasm cerebrospinal fluid (CSF) macrophages for diagnosis tuberculous meningitis (TBM) was prospectively compared with Ahuja criteria from 393 consecutive CSF specimens. assay can play an important role TBM, 73.5% 90.7%.