A5091257752- Gut microbiota and health
- Animal Nutrition and Physiology
- Animal Behavior and Welfare Studies
- Clostridium difficile and Clostridium perfringens research
- Trace Elements in Health
- Probiotics and Fermented Foods
- Spine and Intervertebral Disc Pathology
- Neonatal Respiratory Health Research
- Dietary Effects on Health
- Digestive system and related health
- Genomics, phytochemicals, and oxidative stress
- Iron Metabolism and Disorders
- IL-33, ST2, and ILC Pathways
- Nerve injury and regeneration
- Axon Guidance and Neuronal Signaling
- Coenzyme Q10 studies and effects
- Viral gastroenteritis research and epidemiology
- Peroxisome Proliferator-Activated Receptors
- Hydrogen's biological and therapeutic effects
- Pain Mechanisms and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Aldose Reductase and Taurine
- Chemical synthesis and alkaloids
- Weed Control and Herbicide Applications
- RNA modifications and cancer
Zhejiang University
2006-2025
Shanghai East Hospital
2012-2024
Tongji University
2015-2024
Institute of Subtropical Agriculture
2010-2024
Sichuan Animal Science Academy
2018-2024
Hunan Agricultural University
2020-2024
Chinese Academy of Sciences
2008-2024
Nanjing Forestry University
2024
Taiyuan University of Technology
2024
Hunan Vocational College of Safety Technology
2022
Diarrheal disease is a common health problem with complex causality. Although diarrhea accompanied by disturbances in microbial diversity, how gut microbes are involved the occurrence of remains largely unknown. Here, using pig model post-weaning stress-induced diarrhea, we aim to elucidate and enrich mechanistic basis diarrhea. We found significant alterations fecal microbiome, their metabolites, microRNAs levels piglets Specifically, loss ssc-miRNA-425-5p ssc-miRNA-423-3p, which inhibit...
Metabolic syndrome (MetS) is a difficult-to-manage disease that poses significant risk to human health. Here, we show the supplementation of Lactobacillus reuteri ZJ617 ameliorates symptoms MetS in mice induced by high-fat diet. L. modulates host metabolism interacting with microbiome, resulting production spermidine synthesized microbiota. serves as source substrates for microbiota synthesize spermidine, hence preventing decline bacteria responsible production. Spermidine treatment mimics...
The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138+ plasmacyte (PC)-mediated promotion IgA response regulates the symbiosis between Bacteroides uniformis (B. uniformis) and host during period. IgA-skewed PCs is essential for B. to occupy a defined gut luminal niche, thereby fostering stable colonization. Furthermore, within natural niche was perturbed in absence IgA,...
Post-weaning diarrhea (PWD) is a globally significant threat to the swine industry. Historically, antibiotics as well high doses of zinc oxide and copper sulfate have been commonly used control PWD. However, development bacterial resistance environmental pollution created an interest in alternative strategies. In recent years, research surrounding these strategies mechanisms piglet has continually updated. Mechanically, piglets result imbalance intestinal fluid electrolyte absorption...
Seventy-two piglets aged at 25 d were chosen to investigate the effects of Bacillus subtilis DSM32315 supplementation in diets with different protein levels on growth performance, intestinal barrier function, and gut microbiota profile a 42-d trial. The animals allotted four treatment groups randomized complete block design involving 2 (protein levels) × (probiotic factorial arrangement treatments. Two included high CP (HP) (0 14 d, 20.5%; 15 42 19.5%) low (LP) 18%; 17%), added probiotic...
The present study aimed to investigate the effects of dietary zinc sources on growth performance and gut health weaned piglets. In total, 96 Duroc × Landrace Yorkshire (DLY) piglets with an initial average body weight 8.81±0.42kg were divided into four groups, six replicates per treatment pigs replicate. groups as follows: (1) control group, basal diet; (2) sulphate (ZnSO4) diet +100mg/kg ZnSO4; (3) glycine (Gly-Zn) Gly-Zn (4) lactate lactate. whole trial lasted for 28days. Decreased F/G was...
This study investigated the effects of citrus flavonoids (CF) and compared to antibiotics on piglet growth gut health. Weaned piglets were fed either a basal diet (CON) or supplemented with 75 mg/kg chlortetracycline (CTC), 20 CF (CF1), 40 (CF2), 80 (CF3). The group, especially CF3, exhibited improved performance; reduced diarrhea; significantly higher levels serum factors, immunoglobulins, anti-inflammatory cytokines; lower pro-inflammatory factors markers intestinal barrier damage (
Abstract Introduction Trophoblast cells undergo ferroptosis in pregnancy-related diseases. HMGB1 participates pathological ferroptosis. However, whether lipopolysaccharide (LPS) -mediated expression induces the of trophoblast and further spontaneous abortion (SA) remains unknown. Methods ACSL4 were measured villous tissues from 20 women with SA elective abortion. Human HTR-8/SVneo treated LPS to establish an vitro model. The hallmarks including MDA, GSH, Fe 2+ ROS detected using indicated...
Three new ent-kaurane diterpenoids, named pterokaurane M 1-M 3 ( 1- 3) and three C 14 pterosin-sesquiterpenoids, multifidoside A-C 4- 6), along with 18 known compounds, were isolated from the whole plants of Pteris multifida . The structures 6 established using spectroscopic methods, including extensive 2D NMR CD analyses. Compounds 4 5 showed cytotoxicity against HepG2 tumor cell line IC 50 values less than 10 microM.
α-Ketoglutarate (AKG) can act as an antioxidant both in vitro and vivo. However, the mechanisms of protective effects AKG are still not well understood. We evaluated supplementation on regulation constitutive-androstane-receptor (CAR) pathway porcine intestinal cells piglets exposed to H2O2. Our data showed that treatment significantly increased only intra- extracellular levels (26.9 ± 1.31 μmol/g protein, 1064.4 39.80 μmol/L medium) but also those Asp (29.3 0.21 μmol/g, 4.20 0.11 μmol/L),...
Abstract Acetyl-coenzyme A carboxylase (ACCase) plays crucial roles in fatty acid metabolism and is an attractive target for herbicide discovery. Metamifop a novel ACCase-inhibiting that can be applied to control sensitive weeds paddy fields. In this study, the effects of metamifop on chloroplasts, ACCase activity carboxyltransferase (CT) domain gene expression Echinochloa crus-galli were investigated. The results showed interacted with CT E. . three-dimensional structure complex was...
Abstract Early weaning-induced stress causes diarrhoea, thereby reducing the growth performance of piglets. Gut bacterial dysbiosis has emerged as a leading cause post-weaning diarrhoea. The present study aimed to investigate effect capsulized faecal microbiota transplantation (FMT) on gut community, immune response and barrier function Thirty-two weaned barrows were randomly divided into two groups. recipient group was inoculated orally with healthy Tibetan pigs during whole period trial,...
Highly effective targeted tumor recognition via vectors is crucial for cancer detection. In contrast to antibodies and proteins, peptides are direct targeting ligands with a low molecular weight. the present study, peptide magnetic nanovector platform containing lipid bilayer was designed using amphiphile (PA) as skeleton material in controlled manner without surface modification. Fluorescein isothiocyanate-labeled epidermal growth factor receptor (EGFR) nanoparticles (NPs) could...