A5006843151- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Anesthesia and Pain Management
- Sarcoma Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Infections and Treatments
- Wnt/β-catenin signaling in development and cancer
- Management of metastatic bone disease
- Synthesis of β-Lactam Compounds
- Shoulder and Clavicle Injuries
- Endometrial and Cervical Cancer Treatments
- Animal Genetics and Reproduction
- Neuropeptides and Animal Physiology
- Protein Hydrolysis and Bioactive Peptides
- Musculoskeletal synovial abnormalities and treatments
- Phytase and its Applications
- China's Socioeconomic Reforms and Governance
- Orthopedic Surgery and Rehabilitation
- Cholangiocarcinoma and Gallbladder Cancer Studies
Second Affiliated Hospital of Zhejiang University
2015-2024
Zhejiang University Medical College Affiliated Stomatological Hospital
2021
Zhejiang Lab
2021
Zhejiang University
2018-2021
Breast cancer is the leading cause of cancer-related death in women worldwide. Metastatic disease remains primary patients with breast cancer. Basal-like (BLBC) associated aggressive behavior, stem-like phenotype, high histological grade, poor clinical features, and rates recurrences and/or metastasis. However, mechanism BLBC phenotype shaping obscure. Seventeen normal breast/breast cell lines were used for evaluating subtype-markers, WNT targets constitutive components, epithelial...
To evaluate the accuracy and safety of LANCET robotic system, a robot arm assisted operation system for total hip arthroplasty via multicenter clinical randomized controlled trial. A 116 patients were into two groups: THA group (N = 58) conventional 58). General information about was collected preoperatively. Operational time bleeding recorded during surgery. The position acetabular prosthesis evaluated by radiographs one week after surgery compared with preoperative planning. Harris score,...
Objectives To evaluate the morphine-sparing effects of sequential treatment versus placebo in subjects undergoing total knee arthroplasty (TKA), on pain relief, inflammation control and functional rehabilitation after TKA safety. Design Double-blind, pragmatic, randomised, placebo-controlled trial. Setting Four tertiary hospitals China. Participants 246 consecutive patients who underwent elective unilateral because osteoarthritis (OA). Interventions Patients were randomised 1:1 to...
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (Ape1/Ref-1, Ape1) is a multifunctional protein that upregulated in human pancreatic cancer. Ape1 redox domain plays an essential role regulating the effects of reactive oxygen species (ROS) generated during physiological metabolism and pathological stress. In present study, we explored whether ROS affect WNT/β-catenin signaling. We used E3330, small molecule inhibitor activity Ape1, siRNA approach to knock down two cancer cell lines....
Introduction Total knee arthroplasty (TKA) has been regarded as a most painful orthopaedic surgery. Although many surgeons sequentially use parecoxib and celecoxib routine strategy for postoperative pain control after TKA, high quality evidence is still lacking to prove the effect of this sequential regimen, especially at medium-term follow-up. The purpose study, therefore, evaluate efficacy safety intravenous sodium followed by oral in patients with osteoarthritis (OA) undergoing TKA....
Osteosarcoma is the most common primary malignant tumor of bone.Tumorigenic investigation osteosarcoma cell lines may facilitate preclinical studies targeted therapy.Therefore, aim this study was to explore tumorigenicity-associated genes in cells.We found that 138 were highly expressed and 86 lowly tumorigenic (143B, MNNG/HOS, SJSA-1) compared with poorly (MG-63, Saos-2, U-2 OS).Kyoto Encyclopedia Genes Genomes (KEGG) analysis revealed associated amino acids energy metabolism, while cycle...
Cholangiocarcinoma (CCA) is a rare, aggressive and highly lethal tumor. The disease very difficult to diagnose multi-modality treatments are ineffective. To improve our understanding of the biological characteristics CCA, facilitate identification valid treatments, an in-depth characterization two novel Chinese patient-derived primary CCA cell lines was performed. Two were developed labelled ZJU-0826 -1125. characterized with respect phenotypic, molecular, biomarker, functional histological...
Matrix-associated autologous chondrocyte implantation (MACI) has been proven to provide favorable short-term results for chondral defects in knees. However, it remains unclear whether the clinical benefits of MACI persist longer term.The purpose this prospective study was evaluate and radiological outcomes, at short- midterm follow-up, patients undergoing focal knee.Case series; Level evidence, 4.A total 30 consecutive (31 knees) were treated using between October 2010 March 2018. There 24...
Bone metastasis from endometrial cancer (EC) is rare and poorly described. The purpose of the present study was to investigate correlation between clinically accessible factors survival time among EC patients with bone metastasis.We retrospectively identified reviewed 2010 2016, based on Surveillance, Epidemiology End Results (SEER) database. Univariable multivariable Cox regressions were applied evaluate effects clinical variables survival. Kaplan-Meier plots used visually demonstrate...
Objective To study the shortterm clinical outcomes of unicompartmental knee arthroplasty for medial compartmental osteoarthritis, and to compare 2 kinds prosthesis. Methods From March 2010 June 2013, data 43 patients underwent (UKA) were retrospectively analyzed. 17 (17 knees) used rotating platform prosthesis, 26 (28 fixed bearing prosthesis. There 7 males (7 9 females (10 in group, with an average age 64.1 years (range, 54-82 years); while 10 (18 62.2 43-79 years). All presented...
Objective To monitor the autophagy in osteosarcoma cells by constructing three rLC3B fusion expression vectors, respectively. Methods Rat LC3B gene sequence was amplified PCR and cloned into pEGFP-C1 pmCherry-C1 to construct vector of pEGFP-rLC3B pmCherry-rLC3B. Subsequently, EGFP-rLC3B obtained with as a template, pmCherry-C1, so pmCherry-EGFP-rLC3B constructed. Three plasmids were transfected U-2 OS cells, starvation or Rapamycin adopted induce chloroquine Baf-A1 used inhibit...
Objective To investigate the clinical effects of primary revision after artificial hip replacement and causes surgery. Methods A total 344 patients who underwent surgery arthroplasty (THA) femoral head from January 2010 to December 2016 were retrospectively analyzed. There 141 males 203 fe-males, with a mean age 65.64±10.81 years (28-87 years). A 351 revisions performed in 7 pa-tients bilateral revisions. All followed up for 60.38±22.75 months (24-105 months). periprosthet-ic...