A5103802985- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- MRI in cancer diagnosis
- Congenital Heart Disease Studies
- Tissue Engineering and Regenerative Medicine
- Transplantation: Methods and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Mechanical Circulatory Support Devices
- Sarcoma Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Pancreatic and Hepatic Oncology Research
- Electrochemical sensors and biosensors
- Advanced Nanomaterials in Catalysis
- Lanthanide and Transition Metal Complexes
- Organ Transplantation Techniques and Outcomes
- Cancer Cells and Metastasis
- Functional Brain Connectivity Studies
- Viral Infections and Immunology Research
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Nanomaterials and Printing Technologies
- Gastrointestinal disorders and treatments
- Cardiac and Coronary Surgery Techniques
- Glioma Diagnosis and Treatment
Hangzhou Medical College
2008-2025
Zhejiang Provincial People's Hospital
2024
Hangzhou First People's Hospital
2020-2024
Westlake University
2024
Zhejiang Chinese Medical University
2019-2024
United Imaging Healthcare (China)
2024
Gansu Provincial Hospital of TCM
2024
Beijing Anzhen Hospital
2009-2020
Capital Medical University
2012-2020
Zhejiang University
2020
Chitosan (CS) modified silver halide (AgX, X=Cl, Br, I) (CS-AgX) nanoparticles (NPs) were found to possess dual responsive enzyme mimetic activities. In the presence of H2O2, they able oxidize various colorimertic dyes, namely, peroxidase-like activity. Upon photoactivation, CS-AgX NPs could also typical substrates in absence H2O2. Taking CS-AgI as an example, it was that photostimulated mimetics showed several unprecedented advantages over natural peroxidase or other existing alternatives...
BACKGROUND Gastric cancer (GC) is associated with high mortality rates. Bile acids (BAs) reflux a well-known risk factor for GC, but the specific mechanism remains unclear. During GC development in both humans and animals, BAs serve as signaling molecules that induce metabolic reprogramming. This confers additional phenotypes, including ferroptosis sensitivity. Ferroptosis novel mode of cell death characterized by lipid peroxidation contributes universally to malignant progression. However,...
A novel and interesting enzyme-mimicking activity of chitosan-functionalized graphene oxide (CS-GO) upon phototriggering was demonstrated. CS-GO could catalyze oxidation a typical chromogenic substrate (3,3′,5,5′-tetramethylbenzidine, TMB) under visible light (λ ≥ 400 nm) stimulation, which independent destructive H2O2. Visible triggering rapid, clean, versatile means for inducing the enzymelike CS-GO, superior to current peroxidase or mimetics that use H2O2 as an oxidant. Compared natural...
Research on oxidase mimics is challenging but important. In this article, mercury(II) ion enabled citrate-capped silver nanoparticles (Cit–AgNPs) exhibit catalytic activity toward the oxidation of typical chromogenic substrate 3,3′,5,5′-tetramethylbenzidine (TMB) by dissolved oxygen under mild conditions, suggesting a new type mimic. addition, oxidase-like Cit–AgNPs was sensitive to concentration ions and selective towards among other metal ions. Based this, facile colorimetric sensor...
Objective:We wanted to describe the computed tomography (CT) fi ndings of gallbladder tuberculosis (TB) and correlate them with pathologic ndings.Materials Methods: There were seven patients (M:F = 3:4; mean age, 46.3 years; age range, 32 78 years) in whom TB was eventually diagnosed.All underwent cross-sectional imaging CT, a examination retrospective review.CT evaluation done each case, including mass versus nodule, wall thickening (uniform or irregular) enhancement patterns (homogeneous...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline, ultimately culminating in dementia. This study aims to evaluate cerebrovascular reactivity (CVR) functional connectivity (FC) patients with AD mild (MCI) using resting-state magnetic resonance imaging (rs-fMRI), bypassing the requirement for hypercapnia. The cohort comprised 53 patients, 38 MCI 39 normal control (NC) subjects. CVR derived extracting signals within...
ABSTRACT Carbapenem-resistant Morganella morganii (CRMM) isolates, particularly those producing Klebsiella pneumoniae carbapenemase-2 (KPC-2) or New Delhi metallo-β-lactamase-1 (NDM-1), are increasingly being recognized as causative agents of nosocomial infections. However, systematic phylogeography and genetic characterization these isolates worldwide still lacking. Here, through seven years surveillance CRMM in a tertiary hospital, we analyzed the genomic characteristics bla KPC-2 - NDM-1...
The lymphadenitis associated with cat-scratch disease (CSD) is often confused neoplasms by a number of radiologists and clinicians, consequently, unnecessary invasive procedures or surgeries are performed. In the present study, contrast-enhanced computed tomography (CT) magnetic resonance imaging (MRI) findings 10 patients (6 men 4 women) clinically pathologically confirmed CSD were retrospectively analyzed (CT in 3 patients, MRI 6 CT 1 patient) at Second Affiliated Hospital Zhejiang...
The intrahepatic mass-forming cholangiocarcinoma (IMCC) is frequently misdiagnosed as hepatocellular carcinoma (HCC) in patients with cirrhosis, by numerous radiologists and clinical doctors, which results the incorrect therapeutic treatment. A retrospective case-control study was conducted, contrast-enhanced multiple-phase (CEMP) computed tomography (CT) magnetic resonance imaging (MRI) findings of 22 pathologically confirmed IMCC HCC controls underlying liver cirrhosis were analyzed at...
Primary malignant fibrous histiocytoma (MFH) of the pancreas is rare and a distinct clinical entity.We report case recurrence pancreatic MFH with computed tomography (CT) magnetic resonance imaging (MRI) findings.A 67-year-old man presented history decreased body weight over past 6 mo.Abdominal CT revealed large, multilocular cystic mass in head obvious atrophy tail pancreas.After mo postoperatively, MRI demonstrated recurrent large primary area pancreas.The lesion was heterogeneous,...
Osteosarcoma is the most common primary malignant tumor of bone.Tumorigenic investigation osteosarcoma cell lines may facilitate preclinical studies targeted therapy.Therefore, aim this study was to explore tumorigenicity-associated genes in cells.We found that 138 were highly expressed and 86 lowly tumorigenic (143B, MNNG/HOS, SJSA-1) compared with poorly (MG-63, Saos-2, U-2 OS).Kyoto Encyclopedia Genes Genomes (KEGG) analysis revealed associated amino acids energy metabolism, while cycle...
Silver nanowires capped with oleylamine molecules have been prepared in high purity for the first time.
兰海闯 a 曹新华 陈黎明 刘斌 易涛 * ,a ( 复旦大学化学系 上海 200433
Background: Neuroimaging suggests that white matter microstructure is severely affected in Alzheimer's disease (AD) progression. However, whether alterations are confined to specific regions and they can be used as potential biomarkers distinguish normal control (NC) from AD unknown. Methods: In this cross-sectional study, 33 cases of 25 NC were recruited for automatic fiber quantification (AFQ). A total 20 bundles equally divided into 100 segments quantitative assessment fractional...
Magnetic resonance imaging (MRI) is a promising technique widely used in clinical diagnose. Poly(α-amino acid)s are excellent carriers for MRI due to their biocompatibility. PDOPA-b-PSar copolymers (defined as "DoS") synthesized by sequential polymerizations of 3,4-dihydroxy-L-phenylalanine N-thiocarboxyanhydride (DOPA-NTA) and sarcosine (Sar-NTA) initiated neopentylamine tetramethylene sulfone. Mn2+@DoS micelles have been prepared T1-weighted contrast agents according efficient coordination...
Background The application of pulmonary valved conduit to reconstruct the continuity between right ventricles and artery is one major surgeries. This study aimed establish an in vivo model situ implantation using large animals under off-pump condition validate long-term effects artificial conduit. Methods Domesticate juvenile male sheep tissue-engineered porcine were used for experiment: 30 sheep, weighing (15±3) kg (range 13 17 kg) randomly divided into two groups which all operated general...