A5075546579- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
- Carbohydrate Chemistry and Synthesis
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Galectins and Cancer Biology
- Radiopharmaceutical Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- ATP Synthase and ATPases Research
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- RNA Interference and Gene Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Renal and related cancers
- Proteoglycans and glycosaminoglycans research
- MRI in cancer diagnosis
- Cancer Mechanisms and Therapy
- Cell death mechanisms and regulation
- Cardiac Fibrosis and Remodeling
- Breast Lesions and Carcinomas
- S100 Proteins and Annexins
- Cancer-related Molecular Pathways
- Phagocytosis and Immune Regulation
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2023-2024
Nanjing University
2024
Second Affiliated Hospital of Jilin University
2024
Yuncheng Central Hospital
2023
Yuncheng University
2023
Shanxi Medical University
2023
Sixth Affiliated Hospital of Sun Yat-sen University
2023
Nanjing Medical University
2021
Zhejiang University
2014-2020
N-Acetyltransferase 10 (NAT10) has been reported to be expressed at high levels in hepatocellular carcinoma (HCC); however, its role chemoresistance is unclear. This study aimed investigating whether NAT10 regulates the epithelial-mesenchymal transition (EMT) and HCC. HCC cell lines (Huh-7, Bel-7402, SNU387, SNU449) were treated with remodelin, an inhibitor of NAT10, or transfected small inhibitory RNAs (siRNAs) targeting Twist. The EMT was induced by hypoxia. CCK-8 assay used quantify...
Acute lymphoblastic leukemia (ALL) is a malignant disease of the hematologic system. The current treatment based on chemotherapeutic drugs, which are becoming less effective due to drug resistance. TNF-related apoptosis-inducing ligand (TRAIL) an apoptotic protein used treat cancer that does not affect healthy cells. In recent years, however, ALL cells (e.g., U937) have become more resistant TRAIL. A novel andrographolide derivative (AND7) with high efficiency and low toxicity was...
Abstract High mobility group box 1 ( HMGB 1), an important inflammatory mediator, is actively secreted by immune cells and some non‐immune or passively released necrotic cells. has been implicated in many diseases. Our previous published data demonstrated that was up‐regulated heart tissue serum experimental autoimmune myocarditis EAM ); blockade could ameliorate cardiac fibrosis at the last stage of . And yet, until now, no directly showed associated with fibrosis. Therefore, aims present...
Wilms' tumor (WT) is the most common pediatric kidney tumor. MiR-21 one of frequently overexpressed microRNAs in solid tumors, while phosphatase and tensin homolog deleted from chromosome 10 (PTEN) highly mutated suppressor gene. The aim this study was to investigate relationship between miR-21 PTEN WT. expression levels protein were determined by qRT-PCR Western blot analyses WT specimens, respectively. In tissues, significantly higher lower, compared adjacent non-tumorous renal tissues....
Protein-tyrosine phosphatase SHP2 is encoded by the gene PTPN11. hypothesized to have a critical role in cancer, via activation of mutations that been detected several types leukaemia and certain solid tumours, including liver, breast, gastric cervical cancer. However, best our knowledge, there no previous reports evaluating significance expression thyroid The present study evaluated 65 cancer specimens, 40 specimens self‑matched adjacent peritumour tissues normal tissue, using...
Osteosarcoma is the most common primary malignant tumor of bone.Tumorigenic investigation osteosarcoma cell lines may facilitate preclinical studies targeted therapy.Therefore, aim this study was to explore tumorigenicity-associated genes in cells.We found that 138 were highly expressed and 86 lowly tumorigenic (143B, MNNG/HOS, SJSA-1) compared with poorly (MG-63, Saos-2, U-2 OS).Kyoto Encyclopedia Genes Genomes (KEGG) analysis revealed associated amino acids energy metabolism, while cycle...
PDZ-LIM domain-containing Protein 2 (PDLIM2) has been reported to be downregulated in ovarian cancer. However, its exact function and mechanism regulating cancer progression have not elucidated. This work researched the exert effect of PDLIM2 on progression. Briefly, expression clinical tissues patients cells was investigated by qRT-PCR Western blot. The proliferation, colony formation, migration invasion explored via cell counting kit-8, formation Transwell assays. To verify whether...
As the most common malignancy from mediastinum, metabolic reprogramming of thymoma is important in its development. Nevertheless, connection between map and development yet to be discovered. Thymoma was categorized into three subcategories by unsupervised clustering molecular markers for pathway presentation TCGA dataset. Different genes functions enriched were demonstrated through utilization Gene Ontology (GO) analysis. To identify main contributors thymic malignancy, we utilized Set...
Vascular endothelial growth factor (VEGF), angiopoietin (Ang)-1 and -2 regulate angiogenesis might be important in myocardial collateral development. Elevated levels of angiogenic factors patients with coronary artery disease (CAD) have been reported. However, the age-related change CAD remains unclear.Serum VEGF, Ang-1 were measured by enzyme-linked immunosorbent assay kits. Serum significantly higher than those healthy control subjects. In aged <61 years 61 to 70 years, serum >70 Ang-2...
This study aimed to investigate the effect of bile duct-targeting lecithins- (PC-) coupled decorin (DCN) (PC-DCN) nanoliposomes against liver fibrosis in vitro and vivo. We prepared PC-DCN by using rat astrocytes, HSC-T6, verify antifibrosis vitro. First, we established a model carbon tetrachloride-induced fibrosis. were then injected into fibrotic rats via portal vein or duct. The EdU assay was performed analyze cell proliferation. Immunofluorescence staining used detect α-smooth muscle...
Gliomas are the most severe brain tumours with a poor prognosis. Although surgery, postoperative radiotherapy and chemotherapy can improve survival rate of glioma patients, prognosis patients is still poor. In recent years, influence gene-targeted therapy on gliomas has been gradually discovered, intervening occurrence development from perspective gene will significantly treatment Protein Kinase C Casein Substrate in Neurons 1 (PACSIN1) member conserved peripheral membrane protein family...
Background Liver fibrosis normally progresses to cirrhosis and destroys the normal architecture of liver, resulting in liver dysfunction irreversible cirrhosis. The aim this study was investigate anti-fibrosis effect possible underlying mechanisms decorin. Methods mice model induced by intraperitoneal injection 50% (v/v) carbon tetrachloride (CCl 4 ) diluted olive oil (1 ml/kg body weight) once every 2 days for 5 weeks. Three weeks after injecting CCl intraperitoneally, were randomly divided...