A5101943288- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Peripheral Artery Disease Management
- RNA Research and Splicing
- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Anesthesia and Pain Management
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
- Cerebrovascular and Carotid Artery Diseases
- Reconstructive Surgery and Microvascular Techniques
- Cancer, Hypoxia, and Metabolism
- Biosensors and Analytical Detection
- Aortic aneurysm repair treatments
- Periodontal Regeneration and Treatments
- Acute Ischemic Stroke Management
- Cold Atom Physics and Bose-Einstein Condensates
- Epigenetics and DNA Methylation
- Atomic and Subatomic Physics Research
- Insect symbiosis and bacterial influences
- Thermochemical Biomass Conversion Processes
National Institute of Clean and Low-Carbon Energy
2024-2025
Dezhou University
2025
Chinese Academy of Sciences
2006-2025
Qilu Hospital of Shandong University
2025
Zhejiang University
2010-2025
Wuhan Institute of Physics and Mathematics
2023-2025
First Affiliated Hospital of Wannan Medical College
2024-2025
CHN Energy (China)
2025
Nanjing University of Information Science and Technology
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Administration of exosomes derived from mesenchymal stromal cells (MSCs) could improve some neurologic conditions by transferring functional biomolecules to recipient cells. Furthermore, hypoxic progenitor exerted better therapeutic effects in organ injury through specific cargoes. However, there are no related reports about whether MSCs or hypoxia-preconditioned (PC-MSCs) prevent memory deficits Alzheimer disease (AD). In this study, the PC-MSCs were systemically administered transgenic...
Apigenin is a non-toxic dietary flavonoid with anti-tumor properties. We recently showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression in human ovarian cancer cells under normoxic condition. However, the effect of apigenin angiogenesis remains to be elucidated. Angiogenesis formation new blood vessels required for tumor metastasis. In this study, we HIF-1 VEGF different both hypoxic conditions. demonstrated significantly...
The general transcription factor IID (TFIID) is a critical component of the eukaryotic preinitiation complex (PIC) and responsible for recognizing core promoter DNA initiating PIC assembly. We used cryo-electron microscopy, chemical cross-linking mass spectrometry, biochemical reconstitution to determine complete molecular architecture TFIID define conformational landscape in process TATA box-binding protein (TBP) loading onto DNA. Our structural analysis revealed five states presence TFIIA...
Transcription factor IIH (TFIIH) is a heterodecameric protein complex critical for transcription initiation by RNA polymerase II and nucleotide excision DNA repair. The TFIIH core sufficient its repair functions harbors the XPB XPD DNA-dependent ATPase/helicase subunits, which are affected human disease mutations. additionally requires CdK activating kinase subcomplex. Previous structural work has provided only partial insight into architecture of interactions within pre-initiation...
Transplantation of endothelial progenitor cells (EPCs) is a proven safe and effective method for treatment cerebral ischemia in animal experiments. However, safety efficacy need to be determined clinical trials. We performed two-center, randomized, placebo-controlled phase I/IIa trial with blinded outcome assessment on 18 patients acute infarct within the middle artery territory, followed up 4 years. Autologous ex vivo expanded EPCs were injected intravenously EPC group, who received saline...
Orthopedic and dental implantations under bacterial infection microenvironment face significant challenges in achieving high-quality bone-implant integration. Designing implant coatings that incorporate both immune defense anti-inflammation is difficult conventional single-functional coatings. We introduce a multifunctional nanointerface using zinc finger-inspired peptide-metal-phenolic nanocoating, designed to enhance osseointegration such conditions. Abaloparatide (ABL), second-generation...
Hypoxia-inducible factor 1 complex (HIF-1) plays a pivotal role in oxygen homeostasis and adaptation to hypoxia. Its function is controlled by both the protein stability transactivation activity of its alpha subunit, HIF-1α. Hydroxylation at least two prolyl residues oxygen-dependent degradation domain HIF-1α regulates interaction with von Hippel-Lindau (VHL) that targets for ubiquitination proteasomal degradation. Several hydroxylases have been found specifically hydroxylate In this report,...
Hypoxia-inducible factors (HIFs) are heterodimeric transcription regulating the oxygen supply, glucose metabolism, and angiogenesis. HIF function requires recruitment of p300/CREB-binding protein, two coactivators with histone acetyltransferase activity, by C-terminal transactivation domain HIF-alpha (HIF-alphaCAD). Histone deacetylase inhibitors (HDAIs) induce differentiation or apoptosis repress tumor growth angiogenesis, hence being explored intensively as anti-cancer agents. Using...
Apigenin, a common dietary flavonoid, has been found to have antitumor properties and therefore poses special interest for the development of chemopreventive and/or chemotherapeutic agent cancers. Here, we demonstrate that apigenin inhibits expression focal adhesion kinase (FAK) migration invasion human ovarian cancer A2780 cells. FAK is non-receptor protein tyrosine downstream integrins growth factors. It plays an important role in We inhibited adhesion, Apigenin attenuated through reducing...
BACKGROUND Metastasis is the primary cause of prostate cancer (PCa) lethality and poses a huge clinical obstacle. Lipocalin 2 (LCN2), member lipocalin family, aberrantly expressed in some human cancers has been implicated progression tumors. However, role LCN2 metastatic capacity poorly understood. METHODS expression was examined by RT-qPCR and/or immunoblotting tissue specimens cell lines LNCaP, C4-2, 22RV1, PC3, DU-145, PC3MM2. protein level serum samples determined ELISA....