A5034794465- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Neurological Disease Mechanisms and Treatments
- Colorectal Cancer Surgical Treatments
- Face and Expression Recognition
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- S100 Proteins and Annexins
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Neural Networks and Applications
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Photodynamic Therapy Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Image Retrieval and Classification Techniques
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Blind Source Separation Techniques
- Diverticular Disease and Complications
- Nerve injury and regeneration
Southern Medical University
2011-2024
Zhujiang Hospital
2011-2024
Chongqing Medical University
2020-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2024
People 's Hospital of Jilin Province
2024
South China Normal University
2007-2020
John Wiley & Sons (United States)
2020
Hudson Institute
2020
Guangdong University of Technology
2019
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2008-2018
Transplantation of endothelial progenitor cells (EPCs) is a proven safe and effective method for treatment cerebral ischemia in animal experiments. However, safety efficacy need to be determined clinical trials. We performed two-center, randomized, placebo-controlled phase I/IIa trial with blinded outcome assessment on 18 patients acute infarct within the middle artery territory, followed up 4 years. Autologous ex vivo expanded EPCs were injected intravenously EPC group, who received saline...
Cysteine (Cys) plays an important role in many physiological activities of human beings. Various diseases are always accompanied by abnormal levels Cys. A series Cys-responsive probes were recently developed. However, most fluorescent have disadvantages and exhibit poor vivo imaging. Therefore, a near-infrared fluorescence (NIRF)/photoacoustic (PA) dual-mode probe with high selectivity sensitivity (limit detection = 10.6 nM) toward Cys was developed this study. The new Probe I interacted to...
Leucine aminopeptidase (LAP) is involved in tumor cell proliferation, invasion, and angiogenesis, a well-known marker. In recent years, chemiluminescence has been widely used the field of biological imaging, due to it resulting high sensitivity excellent signal-to-noise ratio. Here, we report design, synthesis, evaluation first LAP-activated chemiluminescent probe for LAP detection imaging. The initially had no but produced an extremely strong after release dioxetane intermediate presence...
Glioma is the most common primary intracranial malignant tumor. Despite advances in surgical techniques and adjuvant radio- chemotherapies, prognosis for patients with glioma remains poor. We have explored effects of using genetically modified mesenchymal stem cells (MSCs) to treat rats. Mesenchymal isolated from Sprague-Dawley rats can directly suppress growth C6 vitro. MSCs transplanted intratumorally also significantly inhibit prolong survival glioma-bearing models. producing...
Rheumatoid arthritis (RA) is polygenic autoimmune disease with unclear etiology. MicroRNAs (miRNAs) play a critical role in the pathogenesis of RA. The objective this study was to evaluate miR-146a patients RA receiving Tripterygium wilfordii Hook F (TwHF) treatment. In total, 69 and healthy controls (HC) were included study, received TwHF treatment for 24 weeks. Blood samples collected from HC, peripheral blood mononuclear cells (PBMCs) isolated. Expression analyzed (baseline, 12 weeks...
Expansion of bone marrow-derived endothelial progenitor cells (EPCs) in vitro to obtain required cell numbers for therapeutic applications faces the challenge growing senescence under traditional normoxic culture condition. We previously found that 1% O2 hypoxic condition is favorable reducing EPCs, but mechanisms underlying favorability are still unclear. Here, we that, compared with normoxia, hypoxia induced a shift lactate dehydrogenase (LDH) isozyme profile, which manifested as decreased...
Abstract Background Post-stroke hyperglycemia appears to be associated with poor outcome from stroke, greater mortality, and reduced functional recovery. Focal cerebral ischemia data support that neural stem cells (NSCs) play an important role in post-ischemic repair. Here we sought evaluate the negative effects of on cellular biology NSCs following anoxia, test whether high glucose affects NSC recovery ischemic injury. Results In this study, used immortalized adult lines induced vitro by 6...
Aged garlic extract (AGE) is widely used as a dietary supplement, and claimed to promote human health through anti-oxidant/anti-inflammatory activities with hypolipidemic, antiplatelet neuroprotective effects. Prior studies of AGE have mainly focused on its organosulfur compounds, little attention paid carbohydrate derivatives, such N-α-(1-deoxy-D-fructos-1-yl)-L-arginine (FruArg). The goal this study investigate actions FruArg antioxidative neuroinflammatory responses in lipopolysaccharide...
Quantitative assessment of serial brain sections provides an objective measure neurological events at cellular and molecular levels but is difficult to implement in experimental neuroscience laboratories because variation from person-to-person the time required for analysis. Whole slide imaging (WSI) technology, recently introduced pathological diagnoses, offers electronic environment a variety computational tools performing high-throughput histological analysis managing associated...
With the advancements in bioinformatic technology, an increasing number of circular RNAs (circRNAs) have been discovered and their crucial roles development progression various malignancies confirmed through multiple pathways. However, specific mechanisms involving protein-binding circRNAs colorectal cancer (CRC) remain largely unexplored. Differential circRNA expression was assessed using a human microarray five CRC tissue paired normal samples. CircGPRC5A then tissues samples qRT-PCR. The...
SB-3CT is a potent and selective inhibitor of matrix metalloproteinase (MMP)-2 -9, which has shown efficacy in an animal model severe traumatic brain injury (TBI). However, poorly water-soluble metabolized primarily to p-hydroxy (2), more than SB-3CT. We synthesized the O-phosphate prodrug (3) compound 2 enhance its water solubility by 2000-fold. The 3 was poor MMP inhibitor, but readily hydrolyzed active human blood. Pharmacokinetics distribution studies mice showed that crossed blood-brain...
Colorectal cancer (CRC) is regarded as one of the most prevalent neoplasms worldwide, and ubiquitination N6-methyladenosine (m6A) modification regulate outgrowth multiple cancers. This study attempted to explore effect ubiquitin-specific peptidases 29 (USP29) on malignant proliferation CRC cells via stabilizing Vir-like m6A methyltransferase associated (VIRMA/KIAA1429). First, upregulations USP29, KIAA1429, SRY-box transcription factor 8 (SOX8) were found in tissues through real-time...
Abstract Acute ischemic stroke (AIS) is caused by clotting in the cerebral arteries, leading to brain oxygen deprivation and infarction. Recombinant human tissue plasminogen activator (tPA) currently only Food Drug Administration-approved drug for stroke. However, tPA has be administered within 4.5 h from disease onset delayed treatment of can increase risk neurovascular impairment, including neuronal cell death, blood-brain barrier (BBB) disruption, hemorrhagic transformation. A key...
Abstract Inhibition of tumor neovascularization has profound effects on the growth solid tumors. Our previous studies have shown effect VEGF165‐PE38 recombinant immunotoxin proliferation and apoptosis in human umbilical vein endothelial cells vitro . In this study, we explored direct inhibition angiogenesis chick chorioallantoic membrane antiangiogenic therapy a malignant glioma model. HEK293 were transfected with pVEGF165PE38‐IRES2‐EGFP plasmid. ELISA was used to confirm expression cells....
Purpose: To assess the anti-metastasis effects of thymol on human colorectal cancer cells. Methods: Human adenocarcinoma cell HT29 was incubated with varying concentrations thymol. Cell viability, migration and invasion were determined by 3-(4, 5-dimethylthiazol-2-yl)-2, 5dipheny-tetrazoliumbromide (MTT) Transwell assays, respectively. Matrix metalloproteinase-2 9 (MMP-2 MMP-9) analyzed gel zymogram assay. Epithelial-mesenchymal transition (EMT)-associated gene expression signaling pathway...
Background.Numerous studies have indicated the engagement of long non-coding RNA (lncRNA) in various cancer types, including colorectal (CRC).However, functional and mechanistic roles lncRNAs CRC remain largely elusive.Objectives.The aim this study was to explore function mechanism lncRNA BVES-AS1 CRC. Materials methods.The expression levels were validated tissues paired normal samples using quantitative real-time polymerase chain reaction (qPCR) Subsequently, biological functions cells...
Abstract:: The kidneys play an irreplaceable role in metabolism and excretion. However, Acute Kidney Injury (AKI) often occurs due to high local concentrations of drugs, inflammation, trauma. Activated optical probes with excellent detection performance can effectively identify biomarkers the initial stage AKI important evaluating preventing development diseases. This article summarizes representative design strategies for molecular special diagnostic applications. These show great potential...